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Intrinsically Disordered Proteins - Dynamics, Binding, and Function (Paperback)
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Intrinsically Disordered Proteins - Dynamics, Binding, and Function (Paperback)
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Intrinsically Disordered Proteins: Dynamics, Binding, and Function
thoroughly examines and ties together the fundamental biochemical
functions of intrinsically disordered proteins (IDPs) and
intrinsically disordered regions (IDRs), including signaling,
binding, and regulation, with the methodology for study and the
associated pathways for drug design and therapeutic intervention.
The role of new mechanistic, computational, and experimental
approaches in IDP study are explored in depth, with methods for the
characterization of IDP dynamics; models, simulations, and
mechanisms of IDP and IDR binding; and biological and medical
implications of IDP dynamics prominently featured. Written and
edited by leading scientists in the field, this book explores
groundbreaking areas such as ensemble descriptions of IDPs and
IDRs, single-molecule studies of IDPs and IDRs, IDPs and IDRs in
membraneless organelles, and molecular mechanisms of fibrillation
of IDPs. Intrinsically Disordered Proteins provides students and
researchers in biochemistry, molecular biology, and applied
microbiology with a comprehensive and updated discussion of the
complex dynamics of IDPs and IDRs.
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