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Books > Science & Mathematics > Chemistry > Physical chemistry > Quantum & theoretical chemistry
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Molecular Diversity in Drug Design (Paperback, Softcover reprint of the original 1st ed. 2002)
Loot Price: R2,782
Discovery Miles 27 820
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Molecular Diversity in Drug Design (Paperback, Softcover reprint of the original 1st ed. 2002)
Expected to ship within 10 - 15 working days
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High-throughput screening and combinatorial chemistry are two of
the most potent weapons ever to have been used in the discovery of
new drugs. At a stroke, it seems to be possible to synthesise more
molecules in a month than have previously been made in the whole of
the distinguished history of organic chemistry, Furthermore, all
the molecules can be screened in the same short period. However,
like any weapons of immense power, these techniques must be used
with care, to achieve maximum impact. The costs of implementing and
running high-throughput screening and combinatorial chemistry are
high, as large dedicated facilities must be built and staffed. In
addition, the sheer number of chemical leads generated may
overwhelm the lead optimisation teams in a hail of friendly fire.
Mother nature has not entirely surrendered, as the number of
building blocks that could be used to build libraries would require
more atoms than there are in the universe. In addition, the
progress made by the Human Genome Project has uncovered many
proteins with different functions but related binding sites,
creating issues of selectivity. Advances in the new field of
pharmacogenomics will produce more of these challenges. There is a
real need to make hi- throughput screening and combinatorial
chemistry into 'smart' weapons, so that their power is not
dissipated. That is the challenge for modellers, computational
chemists, cheminformaticians and IT experts. In this book, we have
broken down this grand challenge into key tasks.
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