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Books > Medicine > Clinical & internal medicine > Geriatric medicine
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Protein Phosphorylation in Aging and Age-Related Disease, Volume 16 (Hardcover, Illustrated Ed)
Loot Price: R2,750
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Protein Phosphorylation in Aging and Age-Related Disease, Volume 16 (Hardcover, Illustrated Ed)
Series: Advances in Cell Aging & Gerontology
Expected to ship within 10 - 15 working days
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It can be argued that ATP is the most important molecule in cells.
Not only is ATP the key energy source for cells, but it is also the
source of phosphate groups that are transferred to a variety of
substrate proteins via the action of elaborate families of protein
kinases. An equally elaborate array of protein phosphatases can
remove phosphate groups from proteins. It is now well established
that protein phosphorylation is a widely used mechanism for cells
to selectively modulate the function of a variety of proteins
including enzymes, ion channels and pumps and structural proteins.
In this volume of ACAG leading experts describe the evidence that
protein phosphorylation is altered in aging and age-related
disease. Protein phosphorylation controls fundamental processes
such as transcription and translation, regulation of the cell
cycle, signalling within and between cells, cell motility, synaptic
function and so on. Recent findings are revealing how
phosphorylation dependent signalling cascades may control lifespan
with a prime example being the insulin-signalling pathway first
described in c-elegans and now emerging as an important regulator
of lifespan of mammals also. Many of the functional changes that
occur during aging such as impaired learning and memory and altered
energy metabolism are controlled by protein phosphorylation and it
is, therefore, important to understand how mechanisms of protein
phosphorylation may either mediate aging or provide adaptive
responses that allow successful disease-free aging. The authors in
addition to considering the roles of protein phosphorylation in
aging describe the evidence that abnormalities in protein
phosphorylation contribute to the pathogenesis of major age-related
diseases including diabetes, atherosclerosis and neurodegenerative
disorders such as Alzheimer's and Parkinson's diseases.
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