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MHC + X - Complex Formation and Antibody Induction (Paperback, Softcover reprint of the original 1st ed. 1988)
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MHC + X - Complex Formation and Antibody Induction (Paperback, Softcover reprint of the original 1st ed. 1988)
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After the discovery of the function of MHC molecules, namely to
provide the context for T cell recognition of foreign antigens, in
1974 Zinkernagel and Doherty made the first drawing of MHC+X (Fig.
1 from Zinkernagel and Doherty, Nature, 251: 547, 1974). Over the
next 18 years a very large number of similar drawings ensued, some
of real artistic beauty. One side of the problem, the nature of the
T cell receptor, was unraveled; however, we still do not know
exactly what kind of a structure the T cell receptor recognizes, al
though in 1987 we learned so much about the structure of MHC
molecules and antigen presentation. In schematic presentations no
one is now placing the foreign antigen beside the MHC molecule, but
rather on top of it, as pointed out by J. L. Strominger at the MHC
+ X meeting in Paris. The complex of MHC and antigen is named MHC +
X, but the precise meaning of this formula remains a "problem
perplex," as illustrated in these proceedings by Peter Par ham.
When planning the Ommen/Amsterdam meeting at the begin ning of
1987, its major aim was seen as to discuss the question of whether
MHC + X can induce antibodies and, consequently, their specificity.
In other terms, whether - in analogy to antigen specific MHC
restricted T cells - MHC restricted antibodies also exist."
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