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Arteriovenous Hemofiltration - A Kidney Replacement Therapy for the Intensive Care Unit (Paperback, Softcover reprint of the original 1st ed. 1985)
Loot Price: R2,932
Discovery Miles 29 320
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Arteriovenous Hemofiltration - A Kidney Replacement Therapy for the Intensive Care Unit (Paperback, Softcover reprint of the original 1st ed. 1985)
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Discovery and Relative Importance of Continuous Arteriovenous
HemofIltration Lee W. Henderson Continuous arteriovenous
hemofiltration (CAVH) has seen a brisk upswing in popularity in
Europe since its introduction by Dr. Kramer and colleagues from
Gottingen, West Germany in 1977 [1]. In the United States, the
technique re- ceived approval as a clinical tool from the Food and
Drug Administration in April 1982. This approval flowed, in no
small measure, from the extensive expe- rience reported from Europe
and in particular West Germany [e. g. , 2, 3]. Reports of its
clinical utility now have begun to appear in the United States [4].
Removal of excess total body water using synthetic membranes in an
extracor- poreal circuit dates back to the work of Alwall and the
artificial kidney that he designed which permitted utilization of a
hydrostatic pressure gradient to moti- vate water flow across the
membrane [5]. Kolffs original rotating drum with its unencased
membrane required an osmotic driving force [6]. Hemofiltration, the
use of the filtration process to remove uremic solutes with the
artificial kidney, in analogy with the glomerulus, was reported in
1967 [7]. This was made possible by the availability of synthetic
membranes with far higher hydraulic permeability (approximately 10
times higher) than conventionally used cellulosic hemodialysis
membrane. Specific applications of these "high flux" membranes to
the removal primarily of excess total body water followed shortly
thereafter [8].
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