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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences
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Animal Models of Dementia (Hardcover, 2011)
Loot Price: R4,893
Discovery Miles 48 930
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Animal Models of Dementia (Hardcover, 2011)
Series: Neuromethods, 48
Expected to ship within 12 - 17 working days
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With an ever-increasing elderly population and the resultant rising
levels of dementia-related disorders, preclinical research based on
animal models is pivotal to our knowledge of underlying molecular
mechanisms and drug discovery aiming at the development of
therapeutic strategies alleviating or preventing the neurological
devastation. In Animal Models of Dementia, expert researchers
provide contributions that stress the importance of extensively
validated animal models in drug discovery and development in order
to predict clinical activity. Beginning with general aspects of
animal modeling, related ethical issues, and essential
methodological considerations, the highly detailed volume then
continues with various levels of model validation, including
pathological, behavioral, neurochemical, pharmacological, and
imaging aspects, followed by sections focused on specific
disorders, such as Alzheimer's disease, Parkinson's disease,
metachromatic leukodystrophy and adrenoleukodystrophy, amyotrophic
lateral sclerosis, frontotemporal dementia as well as vascular
dementia and more. As a volume in the renowned Neuromethods series,
this book offers a detailed, yet accessible, overview of currently
available animal models in the field of dementia research, and
touches, as well, upon more general areas linked to the development
and use of animal models. Comprehensive and efficient, Animal
Models of Dementia will significantly aid both experienced animal
researchers as well as investigators on the verge of beginning
animal model-based dementia research.
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