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Programmed Alternative Reading of the Genetic Code - Molecular Biology Intelligence Unit (Hardcover, 1997 ed.)
Loot Price: R3,242
Discovery Miles 32 420
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Programmed Alternative Reading of the Genetic Code - Molecular Biology Intelligence Unit (Hardcover, 1997 ed.)
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2. The Translational Machinery . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. 5 Translation Initiation in Prokaryotes . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . 6 Translation Initiation in Eukaryotes . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . 8 14 Translation Elongation . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Translation Termination in Prokaryotes . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16
Translation Termination in Eukaryotes . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17
Error Correction in Translation . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . 18 A Structural Basis of Error Correction in
Translation . . . . . . . . . . . . . . . . . . . . . . . . . . 20
Ribosome Editing: A Failsafe Error Correction Mechanism . . . . . .
. . . . . . . . . . 22 Conclusions . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . 22 3. Errors During Elongation Can Cause Translational 29
Frameshifting . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . Spontaneous Frameshifting Versus
Programmed Frameshifting . . . . . . . . . . 30 Spontaneous
Frameshifts Can Be Induced at Specific Codons . . . . . . . . . . .
. 31 4. Programmed +1 Frameshifting . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
41 The pifE Gene of E. coli . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . 41 Using the pifE System to Study
General Frameshifting in E. coli . . . . . . . . 46 Ty
Retrotransposons in Yeast . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . 47 Frameshifting in Retrotransposon Ty1 Occurs by
tRNA Slippage . . . . . . . 48 Frameshifting in Retrotransposon Ty3
Occurs by Out-of-Frame Binding of tRNA . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51 The
Rat Ornithine Decarboxylase Antizyme Gene . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . 56 Summary . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . 62 5. Programmed -1 Frameshifting in
Eukaryotes . . . . . . . . . . . . . . . . . . . . . . . . . . . 69
Programmed -1 Frameshifting in Eukaryotes . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . 69 -1
Frameshifting Occurs on a "Slippery Heptamer" . . . . . . . . . . .
. . . . . . . . . . . . . . . . 71 The Simultaneous-Slippage Model
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . 72 of -1 Frameshifting by a
Downstream Pseudoknot . . . . . . . . . . 77 Stimulation Does the
Pseudoknot Only Block Passage of the Ribosome? . . . . . . . . . .
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