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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Cytoskeleton and Small G Proteins (Paperback, Softcover reprint of the original 1st ed. 1999)
Loot Price: R5,745
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Cytoskeleton and Small G Proteins (Paperback, Softcover reprint of the original 1st ed. 1999)
Series: Progress in Molecular and Subcellular Biology, 22
Expected to ship within 10 - 15 working days
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Animal cells present an extreme variability in their shapes in
relation to their physiological properties. For instance,
fibroblastic cells are tightly attached to the extra-cellular
matrix and display a flattened, spindle-shaped morphology. Neuronal
cells self-organize as a network through a complex branching of
dendrites and a long axonal extension. Resting peripheral blood
lymphocytes are poorly adhesive and maintain a spherical, smooth
shape, while macroph- ages produce many pseudopodal extensions
involved in the recognition of foreign molecules. In addition to
the variability of the morphology of the cells that constitute
different organs, many cell types also modify dynamically their
morphology in response to environmental changes, leading to
differential cell motility, migration, adhesion, polarity or
intercellular contacts. This wide plasticity of cell morphology is
promoted and maintained by the cytoskeleton, which is composed of
the three interconnected actin micro filaments, tubulin
microtubules and intermediate filaments networks, all capable of
assembly and disassembly. Over the past few years, the Rho family
of Ras-like GTPases emerged as key proteins that mediate
extracellular signalling pathways leading to the forma- tion of
polymerized actin-containing structures such as ruffles,
lamellipodia and filopodia. Since the discovery of the first member
RhoA in 1985, 13 mem- bers have so far been characterized in human
cells. Most of Rho proteins are highly conserved between species as
distant as yeast, slime mold, insects and mammals, which points to
their fundamental role in cellular physiology.
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