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Synthetic mRNA - Production, Introduction Into Cells, and Physiological Consequences (Hardcover, 1st ed. 2016)
Loot Price: R6,619
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Synthetic mRNA - Production, Introduction Into Cells, and Physiological Consequences (Hardcover, 1st ed. 2016)
Series: Methods in Molecular Biology, 1428
Expected to ship within 10 - 15 working days
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This volume presents detailed laboratory protocols for in vitro
synthesis of mRNA with favorable properties, its introduction into
cells by a variety of techniques, and the measurement of
physiological and clinical consequences such as protein replacement
and cancer immunotherapy. Synthetic techniques are described for
structural features in mRNA that provide investigational tools such
as fluorescence emission, click chemistry, photo-chemical
crosslinking, and that produce mRNA with increased stability in the
cell, increased translational efficiency, and reduced activation of
the innate immune response. Protocols are described for clinical
applications such as large-scale transfection of dendritic cells,
production of GMP-grade mRNA, redirecting T cell specificity, and
use of molecular adjuvants for RNA vaccines. Written in the highly
successful Methods in Molecular Biology series format, chapters
include introductions to their respective topics, lists of the
necessary materials and reagents, step-by-step laboratory
protocols, and tips on troubleshooting and avoiding known pitfalls.
Synthetic mRNA: Production, Introduction into Cells, and
Physiological Consequences is a valuable and cutting-edge resource
for both laboratory investigators and clinicians interested in this
powerful and rapidly evolving technology.
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