Redirection of Th1 and Th2 Responses (Paperback, Softcover reprint of the original 1st ed. 1999)

It has been 12 years since the first proposal was made to sub- divide mouse CD4 I T cell clones into Th I and Th2 subsets, based on their differences in cytokine production, and 7 years since the first clear demonstration of a similar dichotomy among human T cell clones. In the ensuing period, it has been realized that inappropriate development of Th I or Th2 responses are important features of many immunological and infectious dis- eases. Perhaps the first group of diseases to be understood in terms of preferential Th subset activation were allergic diseases (see PARRONC'HI et aI. , this volume). Several of the major, co- ordinately regulated, features of allergy, including IgE, eosino- philia and mastocytosis, were found to be stimulated by the T- specific cytokines I L-4 and IL-5 and inhibited by the Th I cyto- kine, IFN-. This suggested that the presence and severity of al- lergic responses reflected the relative numbers of Th I and Th2 cells specific for the offending allergen. Similarly, the very dif- ferent consequences of protective Th I and nonprotective Th2 responses to a number of intracellular pathogens have been re- cognized for some time (see TRINCHIERI and SCOTI, and COFF- MAN et aI. , this volume).

General

Imprint:	Springer-Verlag
Country of origin:	Germany
Series:	Current Topics in Microbiology and Immunology, 238
Release date:	2013
First published:	1999
Editors:	Robert L. Coffman • Sergio Romagnani
Dimensions:	235 x 155 x 8mm (L x W x T)
Format:	Paperback
Pages:	150
Edition:	Softcover reprint of the original 1st ed. 1999
ISBN-13:	978-3-662-09711-3
Categories:	Books > Medicine > General issues > Medical equipment & techniques > Medical research Books > Science & Mathematics > Biology, life sciences > Cellular biology > General Books > Science & Mathematics > Biology, life sciences > Microbiology (non-medical) > General Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology > General
LSN:	3-662-09711-7
Barcode:	9783662097113

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