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Adenomatous Polyps of the Colon - Pathobiological and Clinical Features (Hardcover, New)
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Adenomatous Polyps of the Colon - Pathobiological and Clinical Features (Hardcover, New)
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Normal Colon.- A. Anatomic Considerations.- B. Histology.-
Pathology.- A. General Prevalence and Anatomic Distribution.- B.
Gross Appearance.- Multiplicity.- Size.- C. Microscopic Features.-
Tubular versus Villous Adenomas.- Degree of Dysplasia.- Problems in
Grading Dysplasia.- Carcinoma in a Polyp.- Morphometric Studies.-
D. Differential Diagnosis.- Hyperplastic (Metaplastic) Polyps.-
Mixed Hyperplastic-Adenomatous Polyps.- Juvenile Polyps.-
Hamartomatous Polyps.- Polypoid Carcinoma.- Nonepithelial Polyps.-
E. The Diminutive Polyp.- F. Other Characteristics of Polyps.-
Kinetics.- Electron Microscopy.- Histochemistry.- Markers.- Tissue
Culture.- DNA Content.- Doubling Time.- Regression of Polyps.- G.
Histogenesis of Polyps.- Adenomatous Polyposes.- A. Familial
Polyposis Coli and Gardner's Syndrome.- B. Other Adenomatous
Polyposis Syndromes.- C. The Genetics of Adenoma Transmission.-
Malignant Potential of Adenomatous Polyps.- A. Association of
Polyps and Carcinomas.- Risk Factors for Carcinomas among
Polyp-Bearers.- Natural History of Polyps; Metachronous
Carcinomas.- Peak Incidences of Adenomatous Polyps and Colorectal
Carcinomas.- Metachronous Carcinomas in Subjects with Synchronous
Polyps and Carcinomas.- Prevalence of Polyps in Subjects with
Colorectal Carcinomas.- Opposing Views.- B. Histological Evidence
of Malignant Transformation.- C. Adenomatous Remnants in
Carcinomas.- D. Epidemiological Evidence and Etiological Factors.-
Sex and Age.- Relationship of Polyps and Colorectal Carcinomas.-
Dietary and Other Factors.- Etiology.- E. Findings in Experimental
Animals.- Observations.- Genesis of Tumors.- Interpretation of
Findings and Relevance to Humans.- F. Alternate Hypotheses of
Carcinogenesis.- The Flat Mucosa.- Other Routes.- Nonadenomatous
Polyps.- Inflammatory Bowel Disease.- Miscellaneous.- The Field
Effect.- Hereditary Nonpolyposis Colorectal Cancer.- G.
Conclusions.- Evidence of Malignant Potential of Adenomatous
Polyps.- Significance of Malignant Potential of Adenomatous
Polyps.- The Problem of the Metachronous Carcinoma.- Detection and
Management.- A. Screening, Diagnostic, and Surveillance
Techniques.- Principles of Screening.- The At-Risk Population to Be
Screened.- Digital Examination of the Rectum.- Stool Blood Tests.-
Barium Enema (BE).- Endoscopy.- Proctosigmoidoscopy.- Colonoscopy.-
Sensitivity.- Comparisons with Barium Enema.- Effectiveness of
Screening.- B. The Malignant Polyp.- The Problem.- Frequency.- Risk
Factors for Malignancy in a Polyp.- Size.- Multiplicity.- Villous
Component.- Degree of Dysplasia.- Effects of Study Design and Polyp
Processing Technique.- Statistical Analysis.- Adverse Outcomes.-
Level of Submucosal Invasion by Carcinoma.- Postpolypectomy
Therapy.- C. Endoscopic Polypectomy.- How Polyps Are Detected.-
Rationale for Detection and Eradication of Polyps.- Manpower and
Cost Considerations.- Therapy of Diminutive Polyps.- Polypectomy
Technique.- D. Postpolypectomy Surveillance Recommendations.-
Recurrent Polyps.- Risk Factors for New Polyps.- Surveillance
Schedules.- Effectiveness and Cost of Surveillance.- E. The
National Polyp Study.- F. Polyp Registries.- Conclusions.- Glossary
and Abbreviations.
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