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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Infectious & contagious diseases
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The Rhabdoviruses (Paperback, Softcover reprint of the original 1st ed. 1987)
Loot Price: R1,590
Discovery Miles 15 900
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The Rhabdoviruses (Paperback, Softcover reprint of the original 1st ed. 1987)
Series: The Viruses
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The viruses of the family Rhabdoviridae have an exceedingly broad
host range and are widely distributed throughout the animal and
plant king doms. Animal rhabdoviruses infect and often cause
disease in insects, fish, and mammals, including man. The prototype
rhabdovirus, vesicular stomatitis virus VSV), has been extensively
studied and provides perhaps the best model system for studying
negative-strand viruses. The popularity of VSV as a model system is
to a considerable extent due to its relative simplicity and to its
rapid growth, generally to high titer, in many cell types ranging
from yeast to human. The nucleocapsids of these viruses also carry
transcriptional and replicative functions that are expressed in
cell-free systems. The first RNA-dependent RNA poly merase was
described in VSV and its G protein provided an early model system
for studying the synthesis, processing, and membrane insertion of
mammalian glycoproteins. VSV is also highly cytopathogenic and has
been studied quite extensively for its capacity to kill cells and
to shut off cellular macromolecular synthesis. Even earlier, VSV
was discovered to be highly susceptible to the action of
interferons and has served ever since as a means for quantitating
the activity of interferons. To my way of thinking, the spark that
ignited the explosion of re search in this field was struck at the
First International Colloquium on Rhabdoviruses, attended by 30 or
so participants in Roscoff, France, in June 1972."
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