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Books > Science & Mathematics > Biology, life sciences > Biochemistry > Toxicology (non-medical)
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Developmental and Reproductive Toxicology - A Practical Approach (Hardcover, 3rd edition)
Loot Price: R6,039
Discovery Miles 60 390
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Developmental and Reproductive Toxicology - A Practical Approach (Hardcover, 3rd edition)
Expected to ship within 12 - 17 working days
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The purpose of this third edition of Developmental and Reproductive
Toxicology is to provide a practical guide to developmental and
reproductive toxicology in a regulatory environment. In addition to
a comprehensive update of current chapters, the third edition been
revised to reflect recent changes in the field. It contains new
chapters that reflect emerging topics of interest, including
testing of biologics (including vaccines), nonhuman primates as
nonclinical models, developmental immunotoxicity testing, in vitro
assays (such as use of zebrafish and stem cells, as well as high
throughput screening), in silico systems modelling, evaluating
mechanisms of reproductive toxicity, in-depth coverage of
neurobehavioral testing, and testing under the EU's REACH
regulations, as well as updated chapters on nonclinical juvenile
toxicity testing, endocrine disruptor screening, and on functional
and computational genomics. The study of hazard and risk associated
with exposure to toxicants during prenatal development has been
expanded in recent years to include effects on development until
the time of puberty. Concern over the adverse effects of chemical
or physical agents on the reproductive processes of both sexes has
increased, and progress has been made in identifying the causes and
mechanisms eliciting congenital defects and determining the
genetic, epigenetic, and environmental factors involved. This book
provides up-to-date guidance on the use and interpretation of the
newest research techniques in developmental and reproductive
toxicology, as well as the more traditional approaches.
Developmental and Reproductive Toxicology, Third Edition: Contains
valuable insights gained from hands-on experience, together with a
critical evaluation of current testing strategies. Includes
guidance for the design, conduct, and interpretation of tests in
all areas of developmental and reproductive toxicity. Contains
reprinted guidelines from major regulatory agencies, as well as
terminology for description of developmental abnormalities in
laboratory animals, for easy reference. Provides guidance for
planning and conducting preclinical toxicity studies and follow-up
studies, and interpreting their results in a regulatory
environment. This book continues to be the ideal practical
reference for developmental and reproductive toxicologists who
perform research in industry, government, and academia and for
anyone who intends to enter these research areas.
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