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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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The Genetic Markers of Human Immunoglobulins (Paperback, Softcover reprint of the original 1st ed. 1970)
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The Genetic Markers of Human Immunoglobulins (Paperback, Softcover reprint of the original 1st ed. 1970)
Series: Molecular Biology, Biochemistry and Biophysics Molekularbiologie, Biochemie und Biophysik, 9
Expected to ship within 10 - 15 working days
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It has long been known that every individual has a large number of
antibodies of different specificities. Antibodies are
gammaglobulins, and protein structure in cells is genetically
determined. The extreme multiplicity of structure of the combining
sites of antibodies relative to the degree of multiplicity
generated by ordinary genetic mechanisms is a fascinating problem
of bio-medical importance. The functional heterogeneity of
reactions mediated by immunoglobulins-is remarkable, ranging from
protection against life-threatening toxins and microbes to the
production of laryngeal edema leading to suffocation and death from
anaphylaxis. An approach to the understanding of immunoglobulin
polymorphism based upon "a knowledge of genetic markers of
immunoglobulin structure is not biased by the question of whether
or not this polymorphism is related to combining site diversity.
Though several recent reviews of the multifacetted problems related
to immuno globulins are available, it was decided to publish this
survey in the belief that know ledge of the genetic markers of
immunoglobulins prqvides such information about immunoglobulin
differentiation and its control as cannot be obtained from other
sources. Several of the human genetic im unoglobulin markers are
well understood at the molecular level. The Gm system may serv as a
model for other immuno genetic systems. The published data on the
human immunoglobulin factors are widely scattered in journals of
different perspectives. There is a need for a systematic
presentation of these data and for their critical evaluation."
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