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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Regulation of Ca2+-ATPases,V-ATPases and F-ATPases (Paperback, Softcover reprint of the original 1st ed. 2016)
Loot Price: R5,517
Discovery Miles 55 170
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Regulation of Ca2+-ATPases,V-ATPases and F-ATPases (Paperback, Softcover reprint of the original 1st ed. 2016)
Series: Advances in Biochemistry in Health and Disease, 14
Expected to ship within 10 - 15 working days
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The biological membranes of cellular organization enfold an
important group of membrane proteins called the ATPases, which are
not only versatile in maintaining chemical gradient and electrical
potential across the membrane but also bring metabolites necessary
for cell metabolism and drive out toxins, waste products and
solutes that otherwise can curb cell functions. ATPases are
distributed virtually in all live forms starting from unicellular
to multicellular and also in viruses. There are different types of
ATPases, which differ in function and structure and in the type of
ions they transport. The three main types of the ion pump ATPase
family are: (i) P-type ATPases that transport different ions across
membranes and Ca2+ATPases belongs to this catagory (ii) F-type
ATPase in mitochondria, chloroplasts and bacterial plasma membranes
produce ATP using the proton gradient; and (iii) V-type ATPase
catalyzes ATP hydrolysis to transport solutes and maintains acidic
pH in organelles like lysosomes. Genetic defects in either of the
ATPases cause several diseases and a number of researches have
demonstrated the involvement of the members of ATPases in the cell
pathology and diseases, thereby penetrating exciting new areas of
our understanding. In this book, the authors summarize recent
knowledge about the molecular mechanisms associated with
Ca2+-ATPase, V-ATPase and F-ATPase in intracellular and
extracellular Ca2+ transport, mitochondrial ATP synthase, vesicular
H+ transport, and lysosomal pH regulation. This book thereby
bridges the gap between fundamental research and biomedical and
pharmaceutical applications. The book provides an informative
resource to improve ATPase research and modern therapeutic
approaches toward different life threatening diseases that are
associated with dysregulation of the ATPases.
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