Systems biology is changing the way biological systems are
studied by allowing us to examine the cell and organism as a whole.
Systems biotechnology allows optimal design and development of
upstream to downstream bioprocesses by taking a systems-approach.
E. coli has been a model organism for almost all biological and
biotechnological studies. This book brings together for the first
time the state-of-the-art reviews by the world-leading experts on
systems biology and biotechnological applications of E. coli. The
topics covered include genomics and functional genomics, resources
for systems biology, network analysis, genome-scale metabolic
reconstruction, modelling and simulation, dynamic modelling and
simulation, systems-level analysis of evolution, plasmids and
expression systems, protein synthesis, production and export,
engineering the central metabolism, synthetic biology, and systems
metabolic engineering of E. coli. This book provides readers with
guidance on how a complex biological system can be studied using E.
coli as a model organism. It also presents how to perform synthetic
biology and systems metabolic engineering studies on E. coli with
successful examples, the approaches of which can be extended to
other organisms. This book will be a complete resource for anyone
interested in systems biology and biotechnology.
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