This text discusses the applications, outcomes, and controversies
of using animal models in cancer research and human disease. The
topics include murine models of sporadic and inflammation-related
colon carcinogenesis with particular focus on the AOM/DSS
chemically induced colorectal cancer model; large animal models of
human cardiovascular disease; developments of cell therapeutic
strategies for Alzheimer's disease using animal models; the
techniques and limitations of murine models of human colorectal
cancer; animal models for antineoplastic chemotherapy-induced
alopecia; and development of columnar-lined oesophagus with or
without goblet cells in rate duodengastroesophageal reflux models
through gut regenerative cell lineage (GRCL).
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