The hepatitis C virus (HCV) is a significant public health problem
of international importance. HCV is capable of establishing chronic
infections resulting in progressive liver damage and other
problems. Current drug therapies are ineffective, highlighting the
need for better antiviral drugs. Recent research in HCV genetics
and molecular biology have led to significant advances in our
understanding of the life cycle of this important pathogen and may
ultimately lead to better antiviral strategies. The editors of this
book have recruited experts from around the world to produce a
timely and well-compiled review of current HCV research, with an
emphasis on antiviral drug development. The chapters provide
in-depth reviews of the most critical areas of research. Topics
include: the HCV life cycle * HCV assays * HCV resources * HCV
databases * HCV infection systems * models of hepatitis C
infections * overview of the drug pipeline * clinical trial design
* clinical virology and drug development * NS3 protease inhibitors
* NS3-NS4A complex inhibitors * NS3 helicase inhibitors * NS4B
targets and inhibitors * NS5A inhibitors * nucleoside inhibitors *
NS5B polymerase inhibitors * glycoprotein-dependent entry * host
cell targets and inhibitors * innate immunity for HCV antiviral
therapy.
General
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