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Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins
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Microbial Cyclic Di-Nucleotide Signaling (Hardcover, 1st ed. 2020)
Loot Price: R5,719
Discovery Miles 57 190
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Microbial Cyclic Di-Nucleotide Signaling (Hardcover, 1st ed. 2020)
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This book explores the broad and diverse biological and
physiological impacts of established and newly discovered cyclic
di-nucleotide second messenger signaling systems, while also
providing descriptions of the intriguing biochemical
characteristics of multiple turnover enzymes and receptors. The
respective chapters discuss the commonalities and diversity of
cyclic di-GMP, cyclic di-AMP and recently discovered cyclic GMP-AMP
signaling systems in manifold Gram-negative and Gram-positive
bacteria. The global human pathogens Mycobacterium tuberculosis,
Vibrio cholerae, Salmonella typhimurium, Escherichia coli and
Streptococcus pneumoniae, the facultative human pathogen
Pseudomonas aeruginosa, global plant pathogens as exemplified by
Xanthomonas campestris and Burkholderia spp., and the omnipresent
probiotic Lactobacilli, as well as environmentally important
photoautotrophic cyanobacteria, the multicellular Myxococcus
xanthus, and chemolithotrophic Acidithiobacillus are among the
representatives of the microbial kingdom that are described. In
turn, the various aspects of bacterial physiology affected by these
signaling systems- e.g. biofilm formation and dispersal, the cell
cycle, motility, virulence, production of antimicrobials,
fundamental metabolism and osmohomeostasis - are discussed in
detail in the context of different microorganisms. Dedicated
chapters focus on the population diversity of cyclic dinucleotide
signaling systems, their tendency to be horizontally transferred,
the cyclic di-GMP signaling system in the social amoeba
Dictyostelium, honorary cyclic (di)nucleotides, and the development
of strategies for interfering with cyclic dinucleotide signaling in
order to manipulate microbial behavior. Taken together, the
chapters provide an authoritative source of information for a broad
readership: beginners and advanced researchers from various
disciplines; individuals seeking a broad overview of cyclic
di-nucleotide signaling; and those who want to learn more about
specific aspects. Also featuring reviews with a forward-looking
perspective, the book offers a valuable source of inspiration for
future research directions.
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