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In Vitro Toxicology (Hardcover, 2nd edition)
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In Vitro Toxicology (Hardcover, 2nd edition)
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Toxicology has made tremendous strides in the sophistication of the
models used to identify and understand the mechanisms of agents
that can harm or kill humans and other higher organisms.
Non-animals or in vitro models started to gain significant use in
the 1960s. As a result of the increased concern over animal
welfare, economic factors, and the need for greater sensitivity and
understanding of mechanisms, interest in in vitro models has risen.
This volume demonstrates that there now exists a broad range of in
vitro models for use in either identifying or understanding most
forms of toxicity. The availability of in vitro models spans both
the full range of endpoints (irritation, sensitization, lethality,
mutagenicity, and developmental toxicity) and the full spectrum of
target organ systems (including the skin, eye, heart, liver, kidney
and nervous system). Chapters are devoted to each of these
speciality areas from a perspective of presenting the principal
models and their uses and limitations.
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