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Genetics and Product Formation in Streptomyces (Paperback, Softcover reprint of the original 1st ed. 1991)
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Discovery Miles 16 390
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Genetics and Product Formation in Streptomyces (Paperback, Softcover reprint of the original 1st ed. 1991)
Series: F.E.M.S. Symposium Series, 55
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The Streptomycetes are industrially widely used microorganisms due
to their ability to produce numerous different chemical compounds.
These show very varied effects upon other living systems, and
result from profound and subtle biochemical and morphological
differentiation during the streptomycete life cycle. It is
therefore not surprising that research on the genetics of
antibiotic biosynthesis and differentiation in this group is
currently progressing rapidly in many countries. Intimately
connected with the production of antibiotics is resistance to them;
analysis of this is giving further information about the origin and
evolution of this class of genes and their hypothesized spread
among other microorganisms. Another interesting feature of the
Streptomyces group is their mycelial growth. Also, their
ecologically important utilization of high molecular weight
compounds requires enzymes to be transported outside the cell to
hydrolyze non-diffusible substrates. Finally, we have as yet
limited understanding of the various mechanisms of genome
rearrangement observed in some of these species; deletions and/or
amplifications of enormous amounts of DNA can occur without
seriously affecting the viability of the organism under laboratory
conditions. The present volume, which includes contributions
addressing the above subjects and others, originates from a meeting
on "Genetics and Product Formation in Streptomyces" sponsored by
the Federation of European Microbiological Societies in Erfurt on
May 1-6 1990. Compared to previous ones of this kind held in 1979,
1983 and 1987 in Weimar, one can point to impressive progress in
the study and applications of Streptomyces genetics.
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