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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences
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Techniques to Investigate Mitochondrial Function in Neurons (Hardcover, 1st ed. 2017)
Loot Price: R4,953
Discovery Miles 49 530
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Techniques to Investigate Mitochondrial Function in Neurons (Hardcover, 1st ed. 2017)
Series: Neuromethods, 123
Expected to ship within 12 - 17 working days
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This volume describes a broad spectrum of experimental approaches
for investigating structure, function, and transport of neuronal
mitochondria in health and disease. Most of these approaches were
only recently developed and range from electron tomography-based 3D
reconstruction of mitochondrial cristae to patch clamp recording
from mitochondria in intact neurons. The chapters in this book
cover topics such as mitochondrial proteomics, fluorescence
lifetime imaging, respirometry and mitophagy, as well as optical
approaches based on the use of genetically engineered fluorescent
sensors for monitoring synaptic ATP and axonal ROS generation,
mitochondrial Ca2+ cycling and pH changes, and mitochondrial
dynamics and axonal trafficking in live neurons. Each chapter also
discusses difficulties, tips, tricks, and precautions to take.
Neuromethods series style chapters include the kind of detail and
key advice from the specialists needed to get successful results in
your laboratory. Cutting-edge and comprehensive, Techniques to
Investigate Mitochondrial Function in Neurons is a valuable and
useful resource for a broad range of investigators interested in
the function of neuronal mitochondria in health and disease states.
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