While steroids from the periphery have profound effects on the
nervous system, the nervous system also produces its own steroids
de novo ( neurosteroids ). The physiological importance of
neurosteroids is beginning to be understood. These steroids
potentially have roles in sedative/hypnotic behavior, anxiety,
learning, and memory. At the cellular level, neurosteroids affect
neuronal excitability, synaptic plasticity and cell proliferation
and survival. Early findings hold promise for future strategies to
treat specific psychologicalconditions and neurological diseases.
This Brief will focus on the current state of understanding of
brainderived neurosteroids."
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