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Books > Medicine > Clinical & internal medicine > Geriatric medicine
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Diabetes, Insulin and Alzheimer's Disease (Paperback, 2010 ed.)
Loot Price: R4,554
Discovery Miles 45 540
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Diabetes, Insulin and Alzheimer's Disease (Paperback, 2010 ed.)
Series: Research and Perspectives in Alzheimer's Disease
Expected to ship within 10 - 15 working days
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The central nervous system controls vital functions by ef?ciently
coordinating peripheral and central cascades of signals and
networks in an orchestrated manner. Historically, the brain was
considered to be insulin independent. These earlier views have been
challenged by ?ndings demonstrating that insulin exerts multiple
actions in the brain, regulating vital biological processes such as
life span, neuronal survival, cognition, reproduction, feeding
behavior, energy balance, and glucose and fat metabolism, and that
inef?cient central action of insulin contributes to the development
of severe pathologies (Banks et al. 2000; Gerozissis 2003, 2004,
2008; Lustman and Clouse 2005; Okamoto et al. 2001; Park 2002;
Perrin et al. 2004; Pocai et al. 2005; Reger et al. 2008; Schwartz
and Porte, 2005; Schubert et al. 2004; van der Heide et al. 2005;
Woods et al. 1979; Wrighten et al. 2008). Insulin and speci?c
insulin receptors are widely distributed in the networks of the
central nervous system related mainly to feeding or cognition
(Baskin et al. 1983; Bruning et al. 2000; Gerozissis 2003, 2008;
Havrankova et al. 1978a, b; Schechter et al. 1996; Schulingkamp et
al. 2000; Schwartz et al. 1992; Zhao et al. 2004). Insulin
receptors located in the synapses of neurons and in astrocytes are
present in high concentrations in the cerebral cortex, olfactory
bulb, hippocampus, amygdala, cerebellum and hypothalamus (Abbott et
al., 1999; Havrankova et al.
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