Transcription factors are the molecules that the cell uses to
interpret the genome: they possess sequence-specific DNA-binding
activity, and either directly or indirectly influence the
transcription of genes. In aggregate, transcription factors control
gene expression and genome organization, and play a pivotal role in
many aspects of physiology and evolution.
This book provides a reference for major aspects of
transcription factor function, encompassing a general catalogue of
known transcription factor classes, origins and evolution of
specific transcription factor types, methods for studying
transcription factor binding sites in vitro, in vivo, and in
silico, and mechanisms of interaction with chromatin and RNA
polymerase."
General
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