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Books > Science & Mathematics > Biology, life sciences > Molecular biology
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B Cell Receptor Signaling (Paperback, Softcover reprint of the original 1st ed. 2016)
Loot Price: R4,228
Discovery Miles 42 280
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B Cell Receptor Signaling (Paperback, Softcover reprint of the original 1st ed. 2016)
Series: Current Topics in Microbiology and Immunology, 393
Expected to ship within 10 - 15 working days
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This volume details our current understanding of the architecture
and signaling capabilities of the B cell antigen receptor (BCR) in
health and disease. The first chapters review new insights into the
assembly of BCR components and their organization on the cell
surface. Subsequent contributions focus on the molecular
interactions that connect the BCR with major intracellular
signaling pathways such as Ca2+ mobilization, membrane phospholipid
metabolism, nuclear translocation of NF-kB or the activation of
Bruton's Tyrosine Kinase and MAP kinases. These elements
orchestrate cytoplasmic and nuclear responses as well as
cytoskeleton dynamics for antigen internalization. Furthermore, a
key mechanism of how B cells remember their cognate antigen is
discussed in detail. Altogether, the discoveries presented provide
a better understanding of B cell biology and help to explain some B
cell-mediated pathogenicities, like autoimmune phenomena or the
formation of B cell tumors, while also paving the way for
eventually combating these diseases.
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