This volume commemorates the 30th anniversary of the discovery in
1971 of the first DNA topoisomerases, i.e topoisomerase I in E.
coli, then provisionally named omega' protein, by the pioneering
work of Jim Wang at Harvard University, who has contributed an
article to this volume: Reflections on an accidental discovery' of
the enzyme. Many kinds of topoisomerase have since been found from
type I through to type VI in a variety of organisms ranging from
viruses to higher eukaryote mammals. The wide distribution of
enzymes in various forms of life implies that the DNA topoisomerase
is essential for life.
In the mid 80's type I and II enzymes were found to be the
intracellular targets of a number of efficacious anticancer drugs
such as doxorubicin, mitoxantrone, etoposide and camptothecin as a
result of a continued efforts of many investigators, especially
Leroy Liu and his collaborators at Johns Hopkins University.
Readers will find a series of chapters written by researchers
actively engaged in the expanding field of topoisomerase and their
inhibitors. The series of chapters cover review articles on
pharmacology and the molecular mechanism of topoisomerase I- and
II-targeting anticancer drugs in mammals and in the yeast
Saccharomyces cerevisiae, which has proved to be a superb model
organism for studies of anticancer drugs. This volume compiles
up-to-date information on the topoisomerase-targeting compounds in
clinical and preclinical development as a useful and important
reference book for students and researchers in the field of
pharmacology, toxicology, oncology and molecular biology.
General
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