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The Paraneuron (Paperback, Softcover reprint of the original 1st ed. 1988)
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The Paraneuron (Paperback, Softcover reprint of the original 1st ed. 1988)
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The regulation of the organism has traditionally been ascribed to
two distinct systems-the nervous and the endocrine. Though
coordination between the two systems has been acknowledged,
researchers and authors have tended to deal with them as comprising
separate categories of cells involved in different activities. With
this approach, a given regulatory mechanism would be evaluated as
to whether it should be accounted for by nervous or endocrine
functions. The past 15 years, however, have witnessed numerous
important discoveries and conceptual developments concerning the
morphological, physiological, and bio chemical relations between
the nervous and endocrine systems. Advances in im munocytochemical
studies have revealed that there are a wide variety of messenger
substances that function in both regulatory systems. As a result,
researchers have been stimulated to investigate neuronlike
properties of endocrine cells and, con versely, endocrine or
secretory features of neurons. It has thus become obvious that the
rigidities in the classic criteria of neurotransmitters and
hormones may rather impede further advances in these research
fields. The activities of neurons are no longer evaluated simply in
terms of EPSP, IPSP, and the release of classic trans mitters such
as acetylcholine, noradrenaline, and GABA. Hormonal actions are no
longer analyzed solely with regard to concentrations of classic
aminic and peptidic hormones in the systemic blood circulation. The
concept of the paraneuron, which we proposed in 1975, has become
one of the theoretical bases for the development of this trend of
study.
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