This drug is a landmark discovery, which consequently has become
the definitive therapy for the treatment of erectile dysfunction
(ED). Following the major breakthrough in the field of nitric oxide
(NO)-physiology and pharmacology leading to sildenafil being
marketed, the most current information is presented in this
reference book, including ongoing research from several disparate
groups about NO as endothelium-derived relaxing factor (EDRF) and
also as a neurotransmitter for nerves innervating erectile tissue
in mammals.
The development of sildenafil as an oral phosphodiesterase-5
(PDE5) inhibitor drug for the treatment of ED resulted in one of
the first products, which made its way successfully from basic NO
research to routine clinical therapy.
This volume addresses all fields of sildenafil application in
both men and women. In a highly competitive research environment
with a critical medical need for drug improvements the reader will
learn more about clinical resistance to sildenafil treatment and
the modalities to overcome the failure rates.
The individual chapters cover clinical use, pharmacokinetics,
pharmacodynamics, biochemistry, and cultural aspects. They are
written by leading experts in their respective fields. Therefore,
readers whether professionals in the pharmaceutical industry,
physicians treating ED, biochemists, chemists or pharmacologists
will find a detailed and up-to-date knowledge base about current
research activities and an excellent overview for further research
on this compound class and its cultural impact."
General
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