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Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics
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Quorum Sensing vs Quorum Quenching: A Battle with No End in Sight (Hardcover, 2015 ed.)
Loot Price: R4,459
Discovery Miles 44 590
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Quorum Sensing vs Quorum Quenching: A Battle with No End in Sight (Hardcover, 2015 ed.)
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Microbial relationships with all life forms can be as free living,
symbiotic or pathogenic. Human beings harbor 10 times more
microbial cells than their own. Bacteria are found on the skin
surface, in the gut and other body parts. Bacteria causing diseases
are the most worrisome. Most of the infectious diseases are caused
by bacterial pathogens with an ability to form biofilm. Bacteria
within the biofilm are up to 1000 times more resistant to
antibiotics. This has taken a more serious turn with the evolution
of multiple drug resistant bacteria. Health Departments are making
efforts to reduce high mortality and morbidity in man caused by
them. Bacterial Quorum sensing (QS), a cell density dependent
phenomenon is responsible for a wide range of expressions such as
pathogenesis, biofilm formation, competence, sporulation, nitrogen
fixation, etc. Majority of these organisms that are important for
medical, agriculture, aquaculture, water treatment and remediation,
archaeological departments are: Aeromonas, Acinetobacter, Bacillus,
Clostridia, Enterococcus, Pseudomonas, Vibrio and Yersinia spp.
Biosensors and models have been developed to detect QS systems.
Strategies for inhibiting QS system through natural and synthetic
compounds have been presented here. The biotechnological
applications of QS inhibitors (QSIs) in diverse areas have also
been dealt with. Although QSIs do not affect growth and are less
likely to impose selective pressure on bacteria, however, a few
reports have raised doubts on the fate of QSIs. This book addresses
a few questions. Will bacteria develop mechanisms to evade QSIs?
Are we watching yet another defeat at the hands of bacteria? Or
will we be acting intelligently and survive the onslaughts of this
Never Ending battle?
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