Tumor Suppressor Par-4 - Structural Features, Molecular Mechanisms and Function (Hardcover, 1st ed. 2022)

Par-4 is a tumor suppressor protein first discovered and identified in 1993 by Dr. Vivek Rangnekar's laboratory in prostate cancer cells undergoing apoptosis. Par-4 (later also known as PAWR) is a naturally occurring tumor suppressor. Studies have indicated that Par-4 selectively induces apoptosis in cancer cells while leaving normal, healthy, cells unaffected. Mechanisms contributing to the cancer-selective action of Par-4 have been associated with protein kinase A activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. Par-4 is downregulated, inactivated or mutated in diverse cancers. This first of two volumes will be the first on the market on the topic of Par-4, and will provide the opportunity for researchers to discuss the future direction of studies, broaden the scope of research, and contribute a more complete understanding of the molecule's structural features, key functional domains, regulation and relevant basic and clinical/translational facets.

General

Imprint:	Springer Nature Switzerland AG
Country of origin:	Switzerland
Release date:	2022
First published:	2022
Editors:	Vivek M. Rangnekar
Dimensions:	235 x 155mm (L x W)
Format:	Hardcover
Pages:	323
Edition:	1st ed. 2022
ISBN-13:	978-3-03-073571-5
Categories:	Books > Medicine > General issues > Medical equipment & techniques > Medical research Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General
LSN:	3-03-073571-0
Barcode:	9783030735715

Is the information for this product incomplete, wrong or inappropriate? Let us know about it.

Does this product have an incorrect or missing image? Send us a new image.

Is this product missing categories? Add more categories.

Review This Product

No reviews yet - be the first to create one!