Recombinant Technology in Hemostasis and Thrombosis (Paperback, Softcover reprint of the original 1st ed. 1991)

Recent progress in molecular biology has led to a rapid expansion of our understanding of the proteins that are essential for hemostasis and thrombosis. The goal of the XXI Annual Scientific Symposium of the American Red Cross was to provide a forum to explore and document the impact of recombinant DNA technology in this field. The speakers described the essential features of the genes responsible for key plasma proteins important in hemostasis, including procoagulant Factors VIII and IX and anticoagulant proteins, Antithrombin III and Protein C. They emphasized the advances in recombinant DNA technology that have led to the cloning of these genes. Careful examination of the gene sequence has then provided a clearer understanding of the structure of the encoded proteins, and has given additional insight into their functional domains and their interactions in hemostasis. At the same time, these advances have made it possible to better characterize hemostatic disorders. A large number of published studies have shown that the mutations affecting biological activity are clustered in areas that define functional domains. They have led to fundamental advances in our understanding of specific diseases and they have made it possible to develop more accurate and sensitive diagnostic tests for the detection of the disease states.

General

Imprint:	Springer-Verlag New York
Country of origin:	United States
Release date:	March 2013
First published:	1991
Editors:	W. N. Drohan • Leon W. Hoyer
Dimensions:	254 x 178 x 14mm (L x W x T)
Format:	Paperback
Pages:	261
Edition:	Softcover reprint of the original 1st ed. 1991
ISBN-13:	978-1-4613-6644-7
Categories:	Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics Books > Medicine > Clinical & internal medicine > Haematology Books > Science & Mathematics > Biology, life sciences > Biochemistry > General Books > Science & Mathematics > Biology, life sciences > Botany & plant sciences > General Books > Science & Mathematics > Biology, life sciences > Zoology & animal sciences > General
LSN:	1-4613-6644-5
Barcode:	9781461366447

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