This book explores the major cytokines, such as IL-1 and IFN- ,
with respect to the regulation of their gene expression and protein
production in specific immune cell types. It discusses both healthy
physiological settings and in pathological situations in which the
expression of some cytokines could be dysregulated, resulting in
either immunodeficiency or exacerbated inflammatory sequelae in
animal models as well as in human patients. Cytokines are important
regulators of immune responses that require the highly coordinated
participation and communication of multiple cell types. The
expression of cytokines by various producer cell types is therefore
carefully regulated in response to environmental cues at multiple
levels: transcription, translation and posttranslational
modification. Presenting cutting-edge advances in our understanding
of the regulation of cytokine expression, this book is a valuable
resource for anyone involved or interested in immune regulation.
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