Respiratory diseases are leading causes of death and disability
globally, with about 65 million people suffering from COPD, and 334
million from asthma, the most common chronic disease. Each year,
tens of millions of people develop and can die from from
respiratory infections such as pneumonia and TB. Systemic
inflammation may induce and exacerbate local inflammatory diseases
in the lungs, and local inflammation can in turn cause systemic
inflammation. There is increasing evidence of the coexistence of
systemic and local inflammation in patients suffering from asthma,
COPD, and other lung diseases, and the co-morbidity of two or more
local inflammatory diseases often occurs. For example, rheumatoid
arthritis frequently occurs together with, and promotes the
development of, pulmonary hypertension. This co-morbidity
significantly impacts quality of life, and can result in death for
those affected. Current treatment options for lung disease are
neither effective, nor condition-specific; there is a desperate
need for novel therapeutics in the field. Additionally, the
molecular and physiological significance of most major lung
diseases is not well understood, which further impedes development
of new treatments, especially in the case of coexistent lung
diseases with other inflammatory diseases. Great progress has been
made in recent years in many areas of the field, particularly in
understanding the molecular geneses, regulatory mechanisms,
signalling pathways, and cellular processes within lung disease, as
well as basic and clinical technology, drug discovery, diagnoses,
treatment options, and predictive prognoses. This is the first text
to aggregate these developments. In two comprehensive volumes,
experts from all over the world present state-of-the-art advances
in the study of lung inflammation in health and disease.
Contributing authors cover well-known as well as emerging topics in
basic, translational, and clinical research, with the aim of
providing researchers, clinicians, professionals, and students with
new perspectives and concepts. The editors hope these books will
also help to direct future research in lung disease and other
inflammatory diseases, and result in the development of novel
therapeutics.
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