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Lactoferrin and its Role in Wound Healing (Paperback, 2012 ed.) Loot Price: R2,822
Discovery Miles 28 220
Lactoferrin and its Role in Wound Healing (Paperback, 2012 ed.): Yoshiharu Takayama

Lactoferrin and its Role in Wound Healing (Paperback, 2012 ed.)

Yoshiharu Takayama

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Loot Price R2,822 Discovery Miles 28 220 | Repayment Terms: R264 pm x 12*

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Lactoferrin is an iron-binding glycoprotein belonging to the transferrin family. It acts as a defense in host animals against microbes and viruses, since it has a broad spectrum of antimicrobial and antiviral activities. Lactoferrin has been shown to regulate the growth and differentiation of many types of cells. The results of recent studies indicate that lactoferrin is a potent regulator of dermal fibroblasts, and promotes cutaneous wound healing. The collagen gel contraction, a model of wound contraction during wound healing process, and migration of human fibroblasts were enhanced by lactoferrin. LRP-1 (LDL Receptor related Protein-1) acts as a signaling receptor for lactoferrin that mediate fibroblast response to lactoferrin by activating ERK/MAPK signaling pathway. In addition, lactoferrin promotes biosynthesis of extracellular matrix (ECM) component such as type-I collagen and hyaluronan. Hyaluronan is a major component of ECM in connective tissue and promotes wound healing. The promoting effect of lactoferrin on hyaluronan production was accompanied by promotion of HAS2 (hyaluronan synthase 2) expression. These observations suggest that lactoferrin promotes the wound healing by providing an ECM that promotes fibroblast migration. Lactoferrin is also known for its anti-inflammatory and immune modulating properties. According to recent in vivo study, lactoferrin promotes wound repair by promoting the early inflammatory phase of wound healing. Based on this, recombinant human lactoferrin was subsequently tested clinically in a Phase II trial in patients with diabetic ulcers and was found to be effective. Lactoferrin should be further evaluated in patients with diabetic and other types of ulcers.

General

Imprint: Springer
Country of origin: Netherlands
Release date: November 2013
First published: 2012
Authors: Yoshiharu Takayama
Dimensions: 235 x 155 x 6mm (L x W x T)
Format: Paperback
Pages: 108
Edition: 2012 ed.
ISBN-13: 978-9400792029
Categories: Books > Medicine > General issues > Medical equipment & techniques > Medical research
Books > Medicine > Pre-clinical medicine: basic sciences > Physiology > General
Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins
Books > Science & Mathematics > Biology, life sciences > Cellular biology > General
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LSN: 9400792026
Barcode: 9789400792029

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