MicroRNAs (miRNAs), endogenous noncoding regulatory mRNAs of
around 22-nucleotides long, have rapidly emerged as one of the key
governors of the gene expression regulatory program in cells of
varying species, with ever-increasing implications in the control
of the fundamental biological processes and in the pathogenesis of
adult humans. The exciting findings in this field have inspired us
with a premise and a promise that miRNAs will ultimately be taken
to the heart for therapy of human disease. While miRNAs have been
considered potential therapeutic targets for disease treatment, it
remains obscured what strategies we can use to achieve the goal. In
the past years, we have witnessed a rapid evolving of many
creative, innovative, inventive strategies and methodologies
pertinent to miRNA research and applications. These technologies
have convincingly demonstrated their efficacy and reliability in
producing gain-of-function or loss-of-function of miRNAs through
targeting miRNA expression/biogenesis/function, providing new tools
for elucidating miRNA functions and opening up a new avenue for the
development of new agents targeting miRNAs for therapeutic aims.
The present book provides comprehensive descriptions of these
technologies and their applications to miRNA research and to new
drug design for miRNA-related diseases. It starts with an overview
of up-to-date knowledge of miRNA biology and the potential of
miRNAs as therapeutic targets for human disease, followed by an
introduction of the new concept of miRNA interference (miRNAi) and
the perspectives of miRNAi technologies in general terms. In the
following, each chapter introduces one of the miRNAi technologies
with detailed descriptions of state-of-the-art design, procedures,
principles and applications to basic research, R and D and clinical
therapy.
General
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