Study abroad programs offer a unique opportunity for students to immerse themselves within different cultural backgrounds as they continue to further their education. By experiencing this first-hand, in-service and pre-service educators are better prepared to address diversity issues within their classrooms. Efficacy and Implementation of Study Abroad Programs for P-12 Teachers highlights program developments geared towards pre-service and in-service teachers. Featuring the pedagogical opportunities available to participants and the challenges encountered during the development and implementation of study abroad programs, this publication is a critical reference source for pre-service and in-service teachers, school administrators, higher education faculty, educational researchers, and educators in multicultural and international education programs.

Thisbookisintendedformolecularbiologistswhoperformquantitativeanalysesondata emanatingfromtheir?eldandforthestatisticianswhoworkwithmolecularbiologists andotherbiomedicalresearchers. Therearemanyexcellenttextbooksthatprovidefun- mentalcomponentsforstatisticaltrainingcurricula. Therearealsomany"byexpertsfor experts"booksinstatisticsandmolecularbiologywhichrequirein-depthknowledgein bothsubjectstobetakenfulladvantageof. Sofar,nobookinstatisticshasbeenpublished thatprovidesthebasicprinciplesofproperstatisticalanalysesandprogressestoamore advancedstatisticsinresponsetorapidlydevelopingtechnologiesandmethodologiesin the?eldofmolecularbiology. Respondingtothissituation,ourbookaimsatbridgingthegapbetweenthesetwo extremes. Molecularbiologistswillbene?tfromtheprogressivestyleofthebookwhere basicstatisticalmethodsareintroducedandgraduallyelevatedtoanintermediatelevel. Similarly,statisticianswillbene?tfromlearningthevariousbiologicaldatageneratedfrom the?eldofmolecularbiology,thetypesofquestionsofinteresttomolecularbiologists, andthestatisticalapproachestoanalyzingthedata. Thestatisticalconceptsandmethods relevanttostudiesinmolecularbiologyarepresentedinasimpleandpracticalmanner. Speci?cally,thebookcoversbasicandintermediatestatisticsthatareusefulforclassical and molecular biology settings and advanced statistical techniques that can be used to helpsolveproblemscommonlyencounteredinmodernmolecularbiologystudies,such assupervisedandunsupervisedlearning,hiddenMarkovmodels,manipulationandan- ysisofdatafromhigh-throughputmicroarrayandproteomicplatform,andsynthesisof these evidences. A tutorial-type format is used to maximize learning in some chapters. Advicefromjournaleditorsonpeer-reviewedpublicationandsomeusefulinformationon softwareimplementationarealsoprovided. Thisbookisrecommendedforuseassupplementarymaterialbothinsideandoutside classroomsorasaself-learningguideforstudents,scientists,andresearcherswhodealwith numericdatainmolecularbiologyandrelated?elds. Thosewhostartasbeginners,but desiretobeatanintermediatelevel,will?ndthisbookespeciallyusefulintheirlearning pathway. WewanttothankJohnWalker(serieseditor),PatrickMarton,DavidCasey,andAnne Meagher,(editorsatSpringerandHumana)andShanthyJaganathan(Integra-India). The followingpersonsprovidedusefuladviceandcommentsonselectionoftopics,referralto expertsineachtopic,and/orchapterreviewsthatwetrulyappreciate:StephenLooney(a former editor of this book), Stan Young, Dmitri Zaykin, Douglas Hawkins, Wei Pan, Alexandre Almeida, John Ho, Rebecca Doerge, Paula Trushin, Kevin Morgan, Jason Osborne,PeterWestfall,JennyXiang,Ya-linChiu,YolandaBarron,HuiboShao,Alvin Mushlin,andRonaldFanta. Drs. Bang,Zhou,andMazumdarwerepartiallysupported byClinicalTranslationalScienceCenter(CTSC)grant(UL1-RR024996). HeejungBang vii Contents Preface...vii Contributors...xi PARTIBASICSTATISTICS...1 1. ExperimentalStatisticsforBiologicalSciences...3 HeejungBangandMarieDavidian 2. NonparametricMethodsforMolecularBiology...105 KnutM. WittkowskiandTingtingSong 3. BasicsofBayesianMethods...155 SujitK. Ghosh 4. TheBayesiant-TestandBeyond ...179 MithatGonen PARTII DESIGNSANDMETHODSFORMOLECULARBIOLOGY...201 5. SampleSizeandPowerCalculationforMolecularBiologyStudies...203 Sin-HoJung 6. DesignsforLinkageAnalysisandAssociationStudiesofComplexDiseases...219 YuehuaCui,GengxinLi,ShaoyuLi,andRonglingWu 7. IntroductiontoEpigenomicsandEpigenome-WideAnalysis...243 MelissaJ. FazzariandJohnM. Greally 8. Exploration,Visualization,andPreprocessingofHigh-DimensionalData...267 ZhijinWuandZhiqiangWu PARTIII STATISTICALMETHODSFORMICROARRAYDATA ...285 9. IntroductiontotheStatisticalAnalysisofTwo-ColorMicroarrayData...287 MartinaBremer,EdwardHimelblau,andAndreasMadlung 10. BuildingNetworkswithMicroarrayData...315 BradleyM. Broom,WareeRinsurongkawong,LajosPusztai, andKim-AnhDo PARTIV ADVANCEDORSPECIALIZEDMETHODSFORMOLECULARBIOLOGY. . 345 11. SupportVectorMachinesforClassi?cation:AStatisticalPortrait...347 YoonkyungLee 12. AnOverviewofClusteringAppliedtoMolecularBiology ...369 RebeccaNugentandMarinaMeila ix xContents 13. HiddenMarkovModelandItsApplicationsinMotifFindings...405 JingWuandJunXie 14. DimensionReductionforHigh-DimensionalData...417 LexinLi 15. IntroductiontotheDevelopmentandValidationofPredictiveBiomarker ModelsfromHigh-ThroughputDataSets ...435 XutaoDengandFabienCampagne 16. Multi-geneExpression-basedStatisticalApproachestoPredicting Patients'ClinicalOutcomesandResponses...471 FengCheng,Sang-HoonCho,andJaeK. Lee 17. Two-StageTestingStrategiesforGenome-WideAssociationStudies inFamily-BasedDesigns ...485 AmyMurphy,ScottT. Weiss,andChristophLange 18. StatisticalMethodsforProteomics ...497 KlausJung PARTVMETA-ANALYSISFORHIGH-DIMENSIONALDATA ...509 19. StatisticalMethodsforIntegratingMultipleTypesofHigh-ThroughputData. . 511 YangXieandChulAhn 20. ABayesianHierarchicalModelforHigh-DimensionalMeta-analysis...531 FeiLiu 21. MethodsforCombiningMultipleGenome-WideLinkageStudies...541 TreciaA. KippolaandStephanieA. Santorico PARTVI OTHERPRACTICALINFORMATION ...561 22. ImprovedReportingofStatisticalDesignandAnalysis:Guidelines, Education,andEditorialPolicies...5 63 MadhuMazumdar,SampritBanerjee,andHeatherL. VanEpps 23. StataCompanion...599 JenniferSousaBrennan SubjectIndex...627 Contributors CHULAHN* Division of Biostatistics, Department of Clinical Sciences, The Harold C.

Digital Learning in High-Needs Schools examines the challenges and affordances that arise when high-needs school communities integrate educational technologies into their unique settings. Although remote, blended, and networked learning are ubiquitous today, a number of cultural, economic, and political realities-from the digital divide and digital literacy to poverty and language barriers-affect our most vulnerable and under-resourced teachers and students. This book uses critical theory to compassionately scrutinize and unpack the systemic issues that impact high-needs schools' implementation of digital learning tools. Incisive sociocultural analyses across fifteen original chapters explore the intersection of society, technology, people, politics, and education in high-needs school contexts. Informed by real-world cases pertaining to technology infrastructure, formative feedback, Universal Design for Learning, and more, these chapters illuminate how best practices emerge from culturally responsive and context-specific foundations.

Does flexible working really provide a better work-life balance? Throughout the COVID-19 pandemic, flexible working has become the norm for many workers. This volume offers an original examination of flexible working using data from 30 European countries and drawing on studies conducted in Australia, the US and India. Rather than providing a better work-life balance, the book reveals how flexible working can lead to exploitation, which manifests differently for women and men, such as more care responsibilities or increased working hours. Taking a critical stance, this book investigates the potential risks and benefits of flexible working and provides crucial policy recommendations for overcoming the negative consequences.

Digital Learning in High-Needs Schools examines the challenges and affordances that arise when high-needs school communities integrate educational technologies into their unique settings. Although remote, blended, and networked learning are ubiquitous today, a number of cultural, economic, and political realities-from the digital divide and digital literacy to poverty and language barriers-affect our most vulnerable and under-resourced teachers and students. This book uses critical theory to compassionately scrutinize and unpack the systemic issues that impact high-needs schools' implementation of digital learning tools. Incisive sociocultural analyses across fifteen original chapters explore the intersection of society, technology, people, politics, and education in high-needs school contexts. Informed by real-world cases pertaining to technology infrastructure, formative feedback, Universal Design for Learning, and more, these chapters illuminate how best practices emerge from culturally responsive and context-specific foundations.

Haiku, Other Arts, and Literary Disciplines investigates the genesis and development of haiku in Japan and determines the relationships of haiku with other arts, such as essay, painting, and music, as well as the backgrounds of haiku, such as literary movements, philosophies, and religions that underlie haiku composition. By analyzing the poets who played major roles in the development of haiku and its related geners, these essays illustrate how Japanese haiku poets, and American writers such as Emerson and Whitman, were inspired by nature, especially its beautiful scenes and seasonal changes. Western poets had a demonstrated affinity for Japanese haiku, which bled over into other art mediums, as these chapters discuss.

The inclusion of new and emerging technologies in the education sector has been a topic of interest to researchers, educators, and software developers alike in recent years. Utilizing the proper tools in a classroom setting is a critical factor in student success. Tablets in K-12 Education: Integrated Experiences and Implications explores the use of hand-held mobile devices in primary and secondary classrooms to assist in learning, sharing, and communication among students and teachers. With cutting-edge research on pedagogy, practice, and new initiatives for mobile learning devices and applications, this advanced reference source provides educators, technology coordinators, administrators, and other faculty with the resources needed to effectively implement mobile applications in their classrooms.

American Haiku: New Readings explores the history and development of haiku by American writers, examining individual writers. In the late nineteenth century, Japanese poetry influenced through translation the French Symbolist poets, from whom British and American Imagist poets, Amy Lowell, Ezra Pound, T. E. Hulme, and John Gould Fletcher, received stimulus. Since the first English-language hokku (haiku) written by Yone Noguchi in 1903, one of the Imagist poet Ezra Pound's well-known haiku-like poem, "In A Station of the Metro," published in 1913, is most influential on other Imagist and later American haiku poets. Since the end of World War II many Americans and Canadians tried their hands at writing haiku. Among them, Richard Wright wrote over four thousand haiku in the final eighteen months of his life in exile in France. His Haiku: This Other World, ed. Yoshinobu Hakutani and Robert L. Tener (1998), is a posthumous collection of 817 haiku Wright himself had selected. Jack Kerouac, a well-known American novelist like Richard Wright, also wrote numerous haiku. Kerouac's Book of Haikus, ed. Regina Weinreich (Penguin, 2003), collects 667 haiku. In recent decades, many other American writers have written haiku: Lenard Moore, Sonia Sanchez, James A. Emanuel, Burnell Lippy, and Cid Corman. Sonia Sanchez has two collections of haiku: Like the Singing Coming off the Drums (Boston: Beacon Press, 1998) and Morning Haiku (Boston: Beacon Press, 2010). James A. Emanuel's Jazz from the Haiku King (Broadside Press, 1999) is also a unique collection of haiku. Lenard Moore, author of his haiku collections The Open Eye (1985), has been writing and publishing haiku for over 20 years and became the first African American to be elected as President of the Haiku Society of America. Burnell Lippy's haiku appears in the major American haiku journals, Where the River Goes: The Nature Tradition in English-Language Haiku (2013). Cid Corman is well-known not only as a haiku poet but a translator of Japanese ancient and modern haiku poets: Santoka, Walking into the Wind (Cadmus Editions, 1994).

Does flexible working really provide a better work-life balance? Throughout the COVID-19 pandemic, flexible working has become the norm for many workers. This volume offers an original examination of flexible working using data from 30 European countries and drawing on studies conducted in Australia, the US and India. Rather than providing a better work-life balance, the book reveals how flexible working can lead to exploitation, which manifests differently for women and men, such as more care responsibilities or increased working hours. Taking a critical stance, this book investigates the potential risks and benefits of flexible working and provides crucial policy recommendations for overcoming the negative consequences.

This book presents new studies by a group of researchers and practitioners to address many geotechnical challenges, based on the state-of-the-art practices, innovative technologies, new research results and case histories in construction and design towards safer infrastructures. The book provides an advancement in technologies to incorporate the impact of global climate change, world's population is rising fast and the rate of urbanization on civil infrastructures. Papers were selected from the 5th GeoChina International Conference 2018 - Civil Infrastructures Confronting Severe Weathers and Climate Changes: From Failure to Sustainability, held on July 23 to 25, 2018 in HangZhou, China.

Part I: Basic Statistics 1. Experimental Statistics for Biological Sciences Heejung Bang and Marie Davidian 2. Nonparametric Methods in Molecular Biology Knut M. Wittkowski and Tingting Song 3. Basics of Bayesian Methods Sujit K. Ghosh 4. The Bayesian t-Test and Beyond Mithat Goenen Part II: Designs and Methods for Molecular Biology 5. Sample Size and Power Calculation for Molecular Biology Studies Sin-Ho Jung 6. Designs for Linkage Analysis and Association Studies of Complex Diseases Yuehua Cui, Gengxin Li, Shaoyu Li, and Rongling Wu 7. Introduction to Epigenomics and Epigenome-Wide Analysis Melissa J. Fazzari and John M. Greally 8. Exploration, Visualization, and Preprocessing of High Dimensional Data Zhijin Wu and Zhiqiang Wu Part III: Statistical Methods for Microarray Data 9. Introduction to the Statistical Analysis of Two-Color Microarray Data Martina Bremer, Edward Himelblau, and Andreas Madlung 10. Building Networks with Microarray Data Bradley M. Broom, Waree Rinsurongkawong, Lajos Pusztai, and Kim-Anh Do Part IV: Advanced or Specialized Methods for Molecular Biology 11. Support Vector Machines for Classification: A Statistical Portrait Yoonkyung Lee 12. An Overview of Clustering Applied to Molecular Biology Rebecca Nugent and Marina Meila 13. Hidden Markov Model and Its Applications in Motif Findings Jing Wu and Jun Xie 14. Dimension Reduction for High Dimensional Data Lexin Li 15. Introduction to the Development and Validation of Predictive Biomarker Models from High-Throughput Datasets Xutao Deng and Fabien Campagne 16. Multi-GeneExpression-Based Statistical Approaches to Predicting Patients' Clinical Outcomes and Responses Feng Cheng, Sang-Hoon Cho, and Jae K. Lee 17. Two-Stage Testing Strategies for Genome-Wide Association Studies in Family-Based Designs Amy Murphy, Scott T. Weiss, and Christoph Lange 18. Statistical Methods for Proteomics Klaus Jung Part V: Meta-Analysis for High-Dimensional Data 19. Statistical Methods for Integrating Multiple Types of High-Throughput Data Yang Xie and Chul Ahn 20. A Bayesian Hierarchical Model for High-Dimensional Meta Analysis Fei Liu 21. Methods for Combining Multiple Genome-Wide Linkage Studies Trecia A. Kippola and Stephanie A. Santorico Part VI: Other Practical Information 22. Improved Reporting of Statistical Design and Analysis: Guidelines, Education, and Editorial Policies Madhu Mazumdar, Samprit Banerjee, and Heather L. Van Epps 23. Stata Companion Jennifer Sousa Brennan

European welfare states are undergoing profound change, driven by globalization, technical changes, and population ageing. More immediately, the aftermath of the Great Recession and unprecedented levels of immigration have imposed additional pressures. This book examines welfare state transformations across a representative range of European countries and at the EU level, and considers likely new directions in social policy. It reviews the dominant neo-liberal austerity response and discusses social investment, fightback, welfare chauvinism, and protectionism. It argues that the class solidarities and cleavages that shaped the development of welfare states are no longer powerful. Tensions surrounding divisions between old and young, women and men, immigrants and denizens, and between the winners in a new, more competitive, world and those who feel left behind are becoming steadily more important. European countries have entered a period of political instability and this is reflected in policy directions. Austerity predominates nearly everywhere, but patterns of social investment, protectionism, neo-Keynesian intervention, and fightback vary between countries. The volume identify areas of convergence and difference in European welfare state futures in this up-to-date study - essential reading to grasp the pace and directions of change.

European welfare states are undergoing profound change, driven by globalization, technical changes, and population ageing. More immediately, the aftermath of the Great Recession and unprecedented levels of immigration have imposed additional pressures. This book examines welfare state transformations across a representative range of European countries and at the EU level, and considers likely new directions in social policy. It reviews the dominant neo-liberal austerity response and discusses social investment, fightback, welfare chauvinism, and protectionism. It argues that the class solidarities and cleavages that shaped the development of welfare states are no longer powerful. Tensions surrounding divisions between old and young, women and men, immigrants and denizens, and between the winners in a new, more competitive, world and those who feel left behind are becoming steadily more important. European countries have entered a period of political instability and this is reflected in policy directions. Austerity predominates nearly everywhere, but patterns of social investment, protectionism, neo-Keynesian intervention, and fightback vary between countries. The volume identify areas of convergence and difference in European welfare state futures in this up-to-date study - essential reading to grasp the pace and directions of change.