Comprehensive coverage of the entire induced pluripotent stem cell basic work flow Pluripotent stem cells (PSC) can divide indefinitely, self-renew, and can differentiate to functionally reconstitute almost any cell in the normal developmental pathway, given the right conditions. This comprehensive book, which was developed from a training course, covers all of the PSCs (embryonic, embryonic germ, and embryonic carcinoma) and their functions. It demonstrates the feeder-dependent and feeder-free culture of hESC and hiPSC, which will be referred to in all protocols as PSCs. It also addresses the methods commonly used to determine pluripotency, as defined by self-renewal marker expression and differentiation potential. Human Pluripotent Stem Cells: A Practical Guide offers in-depth chapter coverage of introduction to stem cell, PSC culture, reprogramming, differentiation, PSC characterization, and more. It also includes four appendixes containing information on reagents, medias, and solutions; common antibodies; consumable and equipment; and logs and forms. Includes helpful tips and tricks that are normally omitted from regular research papers Features useful images to support the technical aspects and results visually as well as diagrammatic illustrations Presents specific sections (ie: reprogramming, differentiation) in a concise and easily digestible manner Written by experts with extensive experience in stem cell technologies Human Pluripotent Stem Cells: A Practical Guide is an ideal text for stem cell researchers, including principal investigators, and others in university and industry settings, and for new graduate students in PSC labs.

This new addition to the popular 100 cases series explores common clinical scenarios that will be encountered by the medical student and junior doctor during practical training in the emergency department, in the community and in intensive and critical care settings, and which are likely to feature in qualifying examinations. The book covers a broad range of presentations, organized by sub-specialty area for ease of reference. Comprehensive answers highlight key take home points from each case and provide practical advice on how to deal with the challenges that occur when practising emergency and critical care medicine at all levels.

With mounting evidence regarding the role of poor nutrition in the development of chronic diseases such as heart disease and diabetes, it is no secret that appropriate nutrition is crucial to optimal health. Achieving the correct balance of elements provides the body with the ability to adapt to a shifting and often hazardous environment. Never is this capability more important than when a wound is sustained and the body's first line of defense, the skin, is breached. Nutrition and Wound Healing describes the importance of several nutrients, both macronutrients and micronutrients, and their relation to the body's requirements when healing itself. Beginning with an overview to introduce the novice to the fundamentals of nutrition and wound healing, the text analyzes the role of each nutrient, chapter by chapter. The authors discuss carbohydrates, fats, proteins, trace elements, and fat- and water-soluble vitamins. Balanced attention is paid to conditions of deficiency as well as toxic excess as applicable to each nutrient. Specific challenges to healing are considered with individual chapters on burns, cancer, and age extremes. The book also includes a chapter on hormones and the pharmacologic manipulation of wound healing. Specific recommendations for the appropriate administration of each nutrient and variations for individual circumstances are discussed throughout the book. In addition, future directions of research are provided in each chapter to guide young investigators in the field. While many wounds heal well on their own, there are many circumstances when intervention is necessary. Nutrition and Wound Healing provides the clinician, researcher, and even the interested novicewith the information he or she needs to know to help the body heal itself.

Military psychology has become one of the world's fastest-growing disciplines with ever-emerging new applications of research and development. The Routledge International Handbook of Military Psychology and Mental Health is a compendium of chapters by internationally renowned scholars in the field, bringing forth the state of the art in the theory, practice and future prospects of military psychology. This uniquely interdisciplinary volume deliberates upon the current issues and applications of military psychology not only within the military organization and the discipline of psychology, but also in the larger context of its role of building a better world. Split into three parts dedicated to specific themes, the first part of the book, "Military Psychology: The Roots and the Journey," provides an overview of the evolution of the discipline over the years, delving into concepts as varied as culture and cognition in the military, a perspective on the role of military psychology in future warfare and ethical issues. The second part, "Soldiering: Deployment and Beyond," considers the complexities involved in soldiering in view of the changing nature of warfare, generating a focal discourse on various aspects of military leadership, soldier resilience and post-traumatic growth in the face of extreme situations, bravery and character strengths and transitioning to civilian life. In the final section, "Making a Choice: Mental Health Issues and Prospects in the Military," the contributors focus on the challenges and practices involved in maintaining the mental health of the soldier, covering issues ranging from stress, mental health and well-being, through to suicide risk and its prevention, intervention and management strategies, moral injury and post-traumatic stress disorder. Incorporating enlightening contributions of eminent scholars from around the world, the volume is a comprehensive repository of current perspectives and future directions in the domain of military psychology. It will prove a valuable resource for mental health practitioners, military leaders, policy-makers and academics and students across a range of disciplines.

In modern medicine the most functional methodologies are taking an increasing importance in spreading informations, rendering it credible while at the same time using reliable data to focus interaction between basic science and clinical medicine. Critical care medicine embraces these needs and more than any other discipline thrives and develops thanks to interdisciplinary contact.

APICE 2004 has been organised to provide precise answers to these issues. In particular, considerable emphasis has been given to the reviews regarding the most important aspects - or the most significant clinical developments - in the sectors involving variety of functions: neurological, respiratory and cardiovascular, gastrointestinal, metabolism and perfusion; trauma infections, sepsis and organ failure; perioperative medicine and life support techniques; information technology dedicated to clinical medicine, but also as a means of information and education. The contributing authors are all part of leading research groups at the international level in the various sectors presented in the volume.

Accident and emergency departments are the doorway to the hospital for acutely ill and injured patients. Whereas casualty departments have existed for over 150 years, they were often poorly staffed and managed. This book describes the fight to create a new medical specialty of accident and emergency medicine against much opposition from established specialties. The specialty was first recognised in 1972. The book also charts the major developments that occurred in the first 30 years of the specialty.

Das Buch spannt einen weiten Bogen A1/4ber die Transplantationsmedizin und gibt einen Aoeberblick A1/4ber Immunologie, Chirurgie, Vorbereitung und Nachsorge sowie die Randbereiche der Transplantationschirurgie. Es dient Chirurgen, Internisten, Allgemeinmedizinern als auch Medizinstudenten als Nachschlagewerk fA1/4r die thorakale und abdominelle Organtransplantation und soll Grundlagen der Transplantationschirurgie bzw. -medizin vermitteln. Ausserdem informiert es den Leser A1/4ber rechtliche, ethische und organisatorische Aspekte der Transplantationsmedizin und nicht zuletzt A1/4ber die "Physiologie des Hirntodes und die Spenderkonditionierung" sowie A1/4ber den Themenkomplex "Organkonservierung, Transport und Allokation."

Pediatric patients are a unique subset of emergency patients, making up about one-quarter of all emergency department visits. Textbooks regarding the care of pediatric patients are almost universally organized by organ system, which does not facilitate an efficient diagnosis. Taking a case-based approach, Pediatric Emergency Medicine: Chief Complaints and Differential Diagnosis is arranged by chief complaint, using real patient scenarios to help the reader work through the inductive and deductive reasoning needed to assess, evaluate, treat, and disposition pediatric patients with urgent complaints. Cases are structured in the way in which they are presented during medical care, allowing practitioners to become comfortable with the general structure of case presentations: chief complaint, HPI, PMH, ROS, exam, and ancillary studies. This volume also discusses disease processes and their differentiations, providing in-depth knowledge regarding current standards of diagnosis and care.

Leading neurocritical care and intensive care specialists from the Neurosciences Critical Care Unit of the Johns Hopkins Hospital have joined forces to spell out concisely for first line health care providers the diverse standards and therapeutic regimens required for the care of critically ill neurological and neurosurgical patients. Their authoritative reference guide takes an algorithmic approach to immediate patient care, incorporating both ancillary investigation to confirm clinical diagnosis and appropriate management guidelines. The book offers comprehensive summaries of the best diagnostic and management practices for a wide range of neurocritical problems, including encephalopathy, intercerebral and subarachnoid hemorrhage, traumatic brain injury postoperative care, ischemic stroke, brain tumors, spinal cord injury, and more. A compact disk accompanies the book for downloading an ebook version to the reader's PC or PDA.
Authoritative and highly practical, the Handbook of Neurocritical Care offers first-line hospital physicians and EMS personnel a comprehensive quick-reference guide to the rapid diagnosis and management of critically ill neurological and neurosurgical patients.

Continuous update in critical care medicine is a real challenge due to the growing dimensions of its contents; these elements are the result of new research acquisitions, and of those clinical situations where the physician is able to intervene at a given moment, with the use of effective prevention techniques. They are also the result of new technologies able to define complex sub-clinical diagnostic aspects; lastly, they are the result of effective therapeutic techniques available, and of treatment strategies able to influence radically and positively the patient's clinical course. Critical care medicine is playing a key role in the most advanced environments, as it represents a cross-sectional field of action, involving several specialties, such as anesthesiology, general medicine, surgery, pediatrics.

Soon after losing her own daughter in a tragic accident, Hon returns to her childhood home in the Korean countryside after many years away. Her father, a cattle farmer, is elderly and requires her care. He is withdrawn, kind but awkward around his own daughter. As time passes however, Hon realises that her father is far more complex than she ever realised. The discovery of a chest of letters and conversations with his family and friends help Hon piece together the tumultuous story of his life. She learns of her father's experiences during the Korean War and the violence of the 19th April Revolution; of a love affair and involvement in a religious sect; of his sacrifice and heroism and of the phantoms that haunt him. As she unravels secret after secret, Hon grows closer to her father, realising that his lifelong kindness belies a past wrought in both private and national trauma. More than just the portrait of one man, I Went to See My Father opens a window onto humankind, family, loss and war. It asks us to look at the ones we love, uncover the secrets they keep, and finally see who they really are. Flawlessly rendered by award-winning translator Anton Hur, Kyung-Sook Shin has crafted a novel both affectionate and epic, joyous and lasting.

Preface

Introduction

Heino von Prondzynski, Member of the Executive Committee of
F. Hoffmann-La Roche AG and Head of the Diagnostics Division

Winner of the 2002 IFCC-Roche Diagnostics Award

"Apoptosis In Sepsis And Multiple Organ Dysfunction Snydrome"

S. Zeerleder, B. Zwart, W. A. Wuillemin, L. A. Aarden, A. B. J. Groeneveld,
C. Caliez, A. E. M. van Nieuwenhuijze; G. J. van Mierlo, A. J. M. Eerenberg,
B. L??mmle, and C. E Hack

Inflammation ??? Infection ??? Sepsis

Finalists

"Plasma Procalcitonin And C-Reactive Protein In Acute Septic Shock:
Clinical And Biological Correlates"

R. Claeys, S. Vinken, H. Spapen, K. ver Elst, L. Huyghens, F. K. Gorus

National Winners

"4G/5G Promoter Polymorphism In The Plasminogen Activator Inhibitor-1
Gene In Children With Systemic Meningococcaemia"

G. Geishofer, W. Zenz, B. Resch, S. Panzer, G. Endler, D. H??ring,
C. Mannhalter

Hypoxia ??? Ischaemia

Finalist

"Phospholipases A2 Levels And Distribution In Bronchoalveolar Lavage
Fluid Of Patients With Acute Respiratory Distress Syndrome (ARDS):
Application Of A Fluorimetric Method"

E. I. Kitsiouli, G. Nakos, M. E. Lekka

Blood Gases ??? Electrolytes ??? Trace Elements

National Winner

"Magnesium In The ICU"

A. Abraham, A. Bachwani

Cardiology ??? Haemodynamics ??? Stroke

Finalist

"Single-Point Troponin T Measurement On The Day Of Coronary Care
Unit Discharge After Myocardial Infarction Strongly Correlates With
Ejection Fraction And Infarct Size By Nuclear Imaging And With CK-MB
Release"

G. Bonetti, F. Pagani, R. Giubbini, C. Cuccia, M. Panteghini

National Winner

"Soluble Adhesion MoleculesIn Acute Stroke"

A. M. Simundic, V. Basic, E. Topic, V. Demarin, N. Vrkic, B. Kunovic,
M. Stefanovic, A. Begonja

Nephrology

National Winner

"Monitoring Of The Renal Functions During Continuous Renal
Replacement Therapy ??? The Application Of The Analysis Of Cystatin C
And Natriuretic Peptides"

M. Balik, A. Jabor, A. Hendl, M. Kol????, M. Pavlisov??, D. Brestan

Haematology ??? Haemostatis

National Winners

"Serum Levels Of Soluble Transferrin Receptors (sTfR) Correlate Better
With Severity Of Disease Than With Iron Stores In Patients With Malignant
Lymphomas"

J. Bjerner, L. M. Amlie, L. S. Rusten, E. Jakobsen

New Technology ??? Methods

Finalists

"A Rapid And Sensitive Immunoassay For Determination Of S-100 Protein
In A Point-Of-Care Setting"

S. Eriksson, L. Dean, K. Pettersson

National Winner

"A New Approach Of Endotoxin Testing By Using A Monoclonal Antibody
Against Endotoxin (WN1-222/5) And Flow Cytometry"

J. Nolde, F. E. Di Padova, H. Brade H., K. H. Staubach

Organizational Aspects

National Winner

"Improvement Of Critical Care Management In A Healthcare Area By
Implementing Point-Of-Care Testing In Primary Care. A Preliminary
Approach"

M. L. Hortas, I. P??rez-Montaut, M. Redondo, N. Montiel, R. Molina,
C. Gonz??lez

Miscellaneous

National Winners

"Studies On The Potential Effect Of Nitrite"

Y. Tian, C. Wang, S. Song

Index

About Roche and the Roche Diagnostics Division

First Responder Care Essentials is the ideal resource for Community First Responders. Grounded in practice and covering the full remit of the CFR role, the book takes you through the skills that you need when working with patients. Topics range from communication skills to manual handling, trauma care and cardiac arrest.

Who were the shell shocked soldiers of the First World War? How did the warfare they experienced, the military discipline they often endured, the medical treatment they encountered shape their post-war lives? Peter Leese's Shell Shock, now published for the first time in paperback, narrates their stories to demonstrate the wider implications of shell shock. In its origins, shell shock in the Great War tells us about the new industrial technologies and mentalities of modernity. In its after-life, shell shock helps us understand the histories of violence, trauma and memory through the twentieth and into the twenty-first century.

Originally published in 1994, this was the first volume to look in depth at the way the brain responds to trauma and subsequently integrates and influences behavioural, metabolic, neurohumoral, cardiovascular and immune functions. At the time, the role of the brain in the control and integration of the responses to injury and infection was becoming increasingly clear. It had been established that some of these responses, such as fever and neuroendocrine changes, responded to the direct influence of the central nervous system. These, and other advances, provided fresh insights into this area and formed a basis for the more effective understanding and clinical management of trauma patients. In this volume, the authors, all international authorities in their fields, discuss data from experimental and clinical studies and considered the implications of these findings for the treatment of the trauma patient.

Critically ill and critically injured patients require specialized nutrition support to avoid the complications of progressive malnutrition. There is a paucity of information providing practical solutions to these difficult clinical problems. From Nutrition Support to Pharmacologic Nutrition in the ICU focuses on the theoretical and practical aspects of the management of this high-risk patient population. Each chapter presents a state-of-the-art discussion of nutritional and metabolic issues relevant to this resource-intensive patient population and contains current references, liberal tables and figures, and the personal insights of recognized international leaders in this field.

This book describes how the integrated approach offered by health services research can improve the quality of care provided to critically ill patients. By focusing on the needs of the patient, health services research links conventional scientific disciplines, systems research, education, and management, with the aim of translating developments in knowledge into sustained change in culture and practice. Intensive care has much to offer in this respect, as it can both benefit from and contribute to the collaborative methodology of health services research. Although the contributions are directed at critical care, the content is relevant to all health care disciplines, including health services administration.

Researchers from many disciplines, with both basic and clinical perspectives, came together in this volume to review and debate issues pertaining to the investigation and control of tissue oxygenation in acute medicine, as well as treatments to improve tissue oxygenation when abnormal. In this latter context, special emphasis is placed on understanding the effect of blood substitutes on the circulation and on the potential roles of this family of compounds in clinical medicine.

The coronary circulation is central to sustaining myocardial viability. Unlike the cir culations of most other organs, if the coronary circulation becomes insufficient to sustain myocardial contractile function, overall quality of life rapidly declines and life can abruptly end. In partnership with the cerebral circulation, the coronary circula tion plays a central role in sustaining life. However, unlike the cerebral circulation, whose function is self-sufficient to define life, the coronary circulation determines global blood flow and thus the initial state for the remainder of the body. This unique condition, together with the reality that coronary artery disease primarily affects peo ple in their productive years of life, has allowed physicians and scientists who study the heart to enjoy a privileged position in the field of medical research and clinical practice. Thus, it comes as little surprise that many new and exciting research developments involving the coronary circulation have recently come to the forefront of medical thinking. This reality, coupled with the large number of clinical trials of agents specif ically designed to sustain or improve coronary flow in many disease states, makes the timing of this monograph relevant. The book features papers presented at a recent international symposium, the fourth in a series of meetings on Applied Physiology of the Peripheral Circulation. The papers selected by the editors review the most impor tant advances in the fields of cardiology and the coronary circulation."

Eine echte Enzyklop die der Notfallmedizin, bedarfsgerecht im praktischen Taschenbuch-Format, umfassend, kompakt, bersichtlich.
Blitzschnell kompetente Entscheidungshilfen:
-> rund 2000 klar strukturierte Eintr ge in griffiger Didaktik mit anschaulichen Abbildungen und Tabellen
-> notfallmedizinische und feuerwehrtechnische Begriffe, ber 150 Notfallmedikamente mit Dosierungen und Therapie-Strategien
-> aktuelle Empfehlungen und Algorithmen der internationalen Fachgesellschaften
Das Wissen f r Ihre Sicherheit im Beruf und in der Ausbildung.

Even if in the last years more information on sepsis and new treatments has become available, mortality rate is however high. In fact, the complexity of the several biohumoral factors involved in this process is difficult to understand. Another major problem is the consequent organ failure, which grows in a sequential way and in relation with the lesion gravity and the functional reserves of the patient. The volume presents the most recent results of research in this field.

A unique textbook in cardiovascular emergencies Cardiovascular Problems in Emergency Medicine takes you on rounds with the leading teachers of emergency medicine. Transcripts of in-depth telephone conferences on 27 real-life cardiovascular cases provide a unique and fascinating insight into the way complex cases are diagnosed and managed by some of the most experienced and respected practitioners in the field. Each chapter is then complemented by an authoritative, fully-referenced review of the current literature on the topic. With its unique approach, and the range of cases covered, Cardiovascular Problems in Emergency Medicine is an invaluable source of information for all emergency physicians, both qualified and in training.

Critical care medicine is a relatively new specialty. Over the past few decades, we have seen an enormous growth in the number of inten sive care units (ICUs) worldwide. Medical students, residents, fellows, attending physicians, critical care nurses, pharmacists, respiratory ther apists, and other health-care providers (irrespective of their ultimate field of practice) will spend several months or years of their profes sional lives taking care of critically ill or severely injured patients. These clinicians must have special training, experience, and compe tence in managing complex problems in their patients. In addition, they must interpret the data obtained by many kinds of monitoring devices, and they must integrate this information with their knowl edge of the pathophysiology of disease. This handbook was written for every practitioner engaged in criti cal care medicine. We have attempted to present basic and generally accepted clinical information and some important formulas as well as laboratory values and tables that we feel will be useful to the practi tioner of critical care medicine. Chapter 1 provides an introduction to the ICU. Chapters 2 through 18 follow an outline format and are divided by organ system (i. e. , neurologic disorders, cardiovascular dis orders), as well as special topics (i. e. , environmental disorders, trauma, toxicology). In addition, many of these chapters review some useful facts and formulas systematically. Finally, Chapters 19 and 20 supply lists of pharmacologic agents and dosages commonly used in the ICU and laboratory values relevant to the ICU.

Qualitatsmanagement im Gesundheitswesen ist in aller Munde. Auch fur den Rettungsdienst ist es ein aktuelles Thema, das an Bedeutung weiter zunimmt. Zahlreiche Rettungsdienstorganisationen in Deutschland, Osterreich und der Schweiz sind bereits zertifiziert und besitzen damit ein Qualitatsmanagementsystem.

Das vorliegende Werk gibt erstmalig einen zusammenfassenden Uberblick uber die verschiedenen Aspekte des Qualitatsmanagement und dessen Bedeutung fur den Rettungsdienst. Es soll Hilfestellung bei der Implementierung und Umsetzung eines Qualitatsmanagementsystems bieten bzw. einen Uberblick uber die verschiedenen Moglichkeiten und Aspekte liefern. Das Werk richtet sich an alle Verantwortlichen im Rettungsdienst, Qualitatsmanager im Rettungsdienst, Rettungsdienstleiter, arztliche Leiter Rettungsdienst, Berater im Qualitatsmanagement und Rettungsdienstmitarbeiter.

Alle Inhalte besitzen fur Deutschland, Osterreich und die Schweiz Gultigkeit bzw. auf Unterschiede in diesen Landern wird explizit hingewiesen."

This book addresses the practical management of mental health scenarios in the emergency setting and offers first-hand reflections on how emergency nurses, practitioners and allied mental health professionals handle these situations. Responding to mental health needs in emergency situations can be profoundly complex. Frequently emergency nurses and other personnel express their feelings of powerlessness, as they do not know what to say or do in order to achieve the best outcome, and have concerns that their intervention may make the situation worse for those in their care. How a practitioner confronts the mental health encounter and takes the essential steps in managing the event can have a critical impact on how that person copes in the future. This book helps readers understand what is involved in mental health work in emergency situations, and the practical, psychosocial and spiritual tensions that arise from managing the event and the sequelae. Moreover, it shows that it may be possible to provide a more effective emergency mental health service. This unique edited book presents critical reflections on aspects of mental health work gathered from the ‘hands-on’ experiences of the personnel. Mental health encounters in the emergency context are described in detail, illustrating not only what emergency nurses and mental health workers ‘do’ when mental health crises occur, but also what they feel about what they ‘do’. Written by a diverse team of emergency and mental health nurses and allied professionals currently engaged in emergency care both in hospital and pre-hospital settings, this book will appeal to emergency nurses and allied health professionals alike.