The placebo effect continues to fascinate scientists, scholars, and clinicians, resulting in an impressive amount of research, mainly in the field of pain. While recent experimental and clinical studies have unraveled salient aspects of the neurobiological substrates and clinical relevance of pain and placebo analgesia, an authoritative source remained lacking until now. By presenting and integrating a broad range of research, "Placebo and Pain" enhances readers knowledge about placebo and nocebo effects, reexamines the methodology of clinical trials, and improves the therapeutic approaches for patients suffering from pain.

Review for "Placebo and Pain: " " This ambitious book is the first comprehensive and unified presentation of the placebo and nocebo phenomena in the area of pain. Written by the international leading experts in the field, the book provides an accurate up-to-date work] on placebo and pain dealing with current perspectives and future challenging issues. --Ted Kaptchuk, " Associate Professor of Medicine, Harvard Medical School
Contains historical aspects of the placebo effectDiscusses biological and psychological mechanisms of placebo analgesic responsesReviews implications of the placebo effect for clinical research and pain managementIncludes methodological and ethical aspects of the placebo effect"

Why write a book on the tourniquet? The tourniquet is used routinely in op- ating theatres throughout the world, but as far as I know there is no single book that surveys the considerable literature that has accumulated. If used sensibly, the tourniquet is a safe instrument. Most of the few complications seen with its use are preventable. However, when something untoward happens, the tour- quet suddenly becomes an interesting subject, particularly if there is the likelihood of medicolegal consequences. This book summarises the scientific background of the tourniquet and describes a safe physiological approach to preventing complications. Examples of medicolegal problems are included. Considerable progress had been made since Lister first excised a tuberculous wrist joint in a bloodless field. Many researchers have studied the effects of ischaemia and pressure on nerves and muscles. Tourniquets have entered the age of computers and are now much more sophisticated. Despite this, there is still much dogma surrounding the tourniquet in operating theatres and in textbooks. This book is aimed at orthopaedic surgeons, anaesthetists and op- ating-theatre staff. I hope that this short text will stimulate a more widespread interest in the tour- quet and improve safe practice.

The 2nd edition of this book describes the recent techniques, strategies, and drugs that have been demonstrated by multicenter randomized trials to influence survival in critically ill, defined as those who have acute failure of at least one organ, due to either a pathological condition or a medical intervention, and require intensive care treatment. Each chapter focuses on a specific procedure, device, or drug. The scope is accordingly wide, with coverage of topics as diverse as noninvasive mechanical ventilation, protective ventilation, prone positioning, intravenous salbutamol in ARDS, high-frequency oscillatory ventilation, mild hypothermia after cardiac arrest, daily interruption of sedatives, tranexamic acid, diaspirin cross-linked hemoglobin, albumin, growth hormone, glutamine supplementation, tight glucose control, supranormal oxygen delivery, and hydroxyethyl starch in sepsis. The topics selection was performed with the help of hundreds of specialists from dozens of countries; they expressed via web if they agreed or not with these topics and if they used them in their daily clinical practice. The clear text is supported by "how to do" sections and "key point" boxes that provide easily accessible practical information. Written by acknowledged international experts, Reducing Mortality in Critically Ill Patients is of interest for a wide variety of specialists, including intensivists, emergency doctors, and anesthesiologists.

It is only natural for someone in pain to attend to the body part that hurts. Yet this book tells the story of persistent pain having negative effects on brain function. The contributors, all leading experts in their respective fields of pain electrophysiology, brain imaging, and animal models of pain, strive to synthesize compelling and, in some ways, connected hypotheses with regard to pain-related changes in the brain. Together, they contribute their clinical, academic, and theoretical expertise in a comprehensive overview that attempts to define the broader philosophical context of pain (disentangling sensical from nonsensical claims), " "list the changes known to take place in the brains of individuals with chronic pain and animal models of pain, address the possible causes and mechanisms underlying these changes, and detail the techniques and analytical methods at our disposal to "visualize" and study these changes.
Philosophical and social concepts of pain; testimonials of chronic-pain patientsClinical data from pain patients brainsAdvances in noninvasive brain imaging for pain patientsCombining theoretical and empirical approaches to the analysis of pain-related brain functionManipulation of brain function in animal models Emerging neurotechnology principles for pain diagnostics and therapeutics"

Most patients with critical cardiac or thoracic conditions will at some stage pass through the cardiothoracic critical care unit. Critical care presents more complex clinical data than any other area of medicine. The new edition of Core Topics in Cardiothoracic Critical Care focuses on the latest practise in the management of patients in cardiothoracic intensive care. The practice of cardiothoracic critical care medicine is constantly evolving, and this new edition reflects the modernized learning styles for trainees. Each chapter includes key learning points as well as sample multiple choice questions and answers to assist in exam preparation. This edition also features updated chapters on ECMO, perioperative management of patients undergoing emergency cardiothoracic surgery, and advanced modes of organ support for patients. This text provides key knowledge in a concise and accessible manner for trainees, clinicians and consultants from specialities and disciplines such as cardiology and anaesthesia, and nursing and physiotherapy.

Part of the popular Core Topics series, this book provides a practical guide to pre-operative assessment for consultants and trainee anaesthetists. Chapters cover comprehensive evidence-based guidance for assessing and managing patients with particular conditions, as well as perioperative risk stratification and challenges of pre-assessment. The chapters have been written by specialists in the respective clinical fields, while all content has been edited by anaesthetists to assure it is relevant and accessible to the anaesthetist in the everyday pre-operative clinic. Written specifically for anaesthetists, this resource will allow every reader to contribute effectively in a multidisciplinary approach when assessing and risk stratifying patients to ensure that they are optimised before surgery.

A STIRRING EXAMINATION OF A LOOMING CRISIS Virtually everyone has taken antibiotics. They can be lifesavers - or they can be useless. But what are they? How are they used? And what happens as the effectiveness of antibiotics begins to decline? Antibiotics: What Everyone Needs to Know (R) examines the personal and societal implications of our planet's most important - and arguably most overused - medications. In a question-and-answer format, it unpacks the most complicated aspects of this issue, including: * How antibiotics are used (and overused) in humans, plants, and livestock * The consequences to date, and the potential crisis ahead, as overuse of existing antibiotics breeds new resistance in bacteria * How the globalized world enables antibiotic resistance more quickly * Collateral damage, individually and societally, of antibiotic use * The difficult decisions ahead related to medical care and the food system Grounded in the latest scientific research and translated for general readers, Antibiotics: What Everyone Needs to Know (R) offers a clear-eyed overview of where we are, and what the future holds, as antibiotics lose their might.

This book will enable readers to understand the principles underpinning the management of pain which a particular emphasis upon the care of the older adult. The chapters will explore concepts that are recognised to be involved in the pain experience but each author will then add their own unique perspective by applying the principles to their specialist area of practice and the care of the older adult. It is structured to include the aims and outcomes of the chapter at the beginning so that readers can track their progress, and provides chapter outlines and further reading suggestions foir this unique topic area.

"Anaesthesia Science" presents the scientific foundations upon which the clinical practice of anaesthesia and care of the critically ill are based.
Written on the basis that basic science underlies the practice of anaesthesia
Contributors include some of the world's most eminent anaesthesiologists
Provides coverage on less well appreciated aspects of the subject, such as the microcirculation, multi-organ failure, and the theory of pain
Thoroughly integrates the clinical practice of anaesthesia with basic sciences, providing all the information needed in one convenient source
Based on the Fellowship of the Royal College of Anaesthetists (FRCA) syllabus and aimed at trainee anaesthetists preparing for the FRCA, the European Diploma of Anaesthesiology and other equivalent examinations.

Designed specifically for the revised Final FRCA examination, this book contains four mock exams, combining the new single best answer format with the traditional true/false format MCQs. A further fifth chapter contains only single best answer questions allowing candidates extra practice on this new and more difficult format. Uniquely the book includes answers with explanations and cross-references to key textbooks, allowing the candidate to read around on more difficult areas. The editor team balances extensive exam experience with recent exam success. Each question has also been expertly reviewed to ensure the highest quality and relevance to the Final FRCA. This is a must buy when preparing for this key exam.

The role of the operating department practitioner has evolved considerably in recent years, and both trainee and practising ODPs need a practical, up-to-date resource on terminology and current practice. Each entry in the second edition of Operating Department Practice A-Z has been fully updated and contains both a short definition and a more detailed description of the term or procedure, with supporting information to give the reader a deeper understanding of the field. In addition, the book contains useful appendices on medical terminology and abbreviations, normal values, medical and scientific symbols, and a list of useful websites for further reference. Written by two of the UK's most experienced Operating Department Practice lecturers, Operating Department Practice A-Z, second edition provides practical, concise information for all peri-operative staff members.

This cutting-edge issue of Anesthesiology Clinics is divided into two sections.? The first covers topics in perioperative clinical information systems (IS), including the following.? The anatomy of an anesthesia information management system; vendor and market landscape; impact of lexicons on adoption of an IS; clinical research using an IS, real-time alerts and reminders using an IS; shortcomings and challenges of IS adoption; creating a real return-on-investment for IS implementation (life after HITECH); Quality improvement using automated data sources and reporting; and opportunities and challenges of implementing an enterprise IS in the OR.? Section 2 is devoted to computers and covers the following topics.? Advanced integrated real-time clinical displays; enhancing point-of-care vigilance using computers; and computers in perioperative simulation and education.

With a focus on anatomy and sonoantomy, this beautifully illustrated updated edition captures the latest advances in the rapidly growing field of ultrasound-guided pain medicine and MSK procedures. This atlas is divided into seven sections that provide an overview and focus on interventional approaches and advancements. Authored by international experts, each clinical chapter features a maximal number of instructive illustrations and sonograms and provides a description of sonoanatomy, instructions on performing the procedure and how to confirm appropriate needle placement. This book will help encourage and stimulate physicians to master approaches in interventional MSK and pain management.

Chronic pelvic pain is a common debilitating condition that impairs quality of life and reproductive function in the female population worldwide. It is also an area in which the level of knowledge is generally poor among gynecologists. This book will help gynecologists and pain management specialists optimize assessment and treatment of women with chronic pelvic pain. It addresses the most common conditions causing chronic pelvic pain in women and offers practical guidelines for treatment. Exploring issues such as pudendal neuralgia and pain caused by pelvic nerve injuries and pelvic mesh. Other sections are dedicated to examining the psychological impact of pelvic pain and the impact of pain on sexuality and relationships. Algorithms on how to work-up and treat patients with chronic pelvic pain are a valuable addition, as well as advice on what to do in situations where known treatments have failed.

One in three people will develop some kind of cancer in their lifetime. The overall cancer incidence has increased by 25% since 1975. Anaesthetic involvement in hospital interactions has been estimated at around 75%, and so anaesthetists are likely to have major input into the care of the cancer patient. This input may start with the preoperative assessment, but often extends to the intensive care unit and the management of both acute and chronic disease, or procedural related pain.
This book is comprised of five main sections dealing with cancer, anaesthesia for cancer surgery, intensive care, pain management and supportive and palliative care. The chapters are authored by acknowledged specialists in their field of cancer patient management. The anaesthesia section discusses not just major surgery but includes the specific and subtle differences that exist in the diverse types of specialist cancer surgery. The pain section deals with the current status of several specific cancer pain problems with contemporary evidence and recent developments in management. This book also introduces novel ways of looking at conventional treatments such as the genetic aspects of opioid use. For a complete understanding of the cancer patient, other aspects of care are also considered, including psychological care and complementary medicines.

Another title in GMM's highly successful QBase series, this time focusing on the Primary FRCA (Fellowship of the Royal College of Anaesthetists) with sets of examination papers the candidate can use to revise and practice their MCQ technique. As always, the self-learning experience is greatly enhanced by the free CD-ROM containing the QBase examination software. This powerful program allows the user to sit the pre-set exams as printed in the book, or to create their own exams using questions drawn from the total pool available on the CD-ROM. The program can either generate these exams randomly (maintaining the same proportions of each subject as the 'pre-set' exams), or the user can select any number of questions in any subject area, to create their very own exam. However the user chooses to set an exam, they can then mark, analyse and store each attempt, and review and re-sit the same exam at a later date, comparing their scores with previous attempts. When re-sitting an exam, the user can also choose to 'shuffle' the question stems A-E, so that they cannot simply remember patterns of true and false answers. A final unique aspect of the program is that it allows the user to select how confident they are of their answer, and the program can then provide feedback on a user's 'guessing strategy'.

In the United States, over half of pregnant women receive some form of anesthesia for their deliveries; this translates into well over 2 million anesthetics per year. With this new handbook, anesthesiologists have easy access to step-by-step, to-the-point information on how to manage patients in specific situations. Every aspect of obstetric anesthesia practice is covered, including patient evaluation, anesthesia for labor and delivery, anesthesia for cesarean delivery, management of patients with concurrent medical problems, management of obstetric emergencies, fetal assessment, and neonatal resuscitation. Distilled, synthesized text is complemented by a generous number of tables, charts, figures and flow diagrams, all presented in accessible handbook format. Obstetric Anesthesia is an ideal introduction to the specialty as well as an essential daily guide for obstetric patient care and management.

New edition of a successful book of concise notes on clinical aspects of the examination for the Fellowship of the Royal College of Anaethetists. It has been fully updated to reflect changes in the examination syllabus. This will be an ideal revision guide for trainee anaesthetists sitting the FRCA and similar examinations. Concise notes for the clinical part of the FRCA Appendix covers the up to date syllabus for the examination Incudes appropriate guidelines and reports from the Association of Anaesthetists Each section ends with list of further reading

Ongoing improvement in the quality of patient care is essential to all anesthesia practices. This issue of Anesthesiology Clinics provides solid foundation and guidance in how to improve outcomes, as it covers the following topics. An overview of QI structures and initiatives is presented, focusing on the relevance to anesthesiology. A practical guide on how to implement a QI program is provided. Quality measurement approaches and issues, including the use of databases and risk adjustment are also examined. How to use simulation and other cutting-edge technology to improve quality in the OR is provided. Issues in multidisciplinary education and enhanced communication are explored. Recommendations for fostering a culture of safety are provided. How real-time support and decision-making can improve performance on quality process measures are examined. Clinical topics including bariatrics, geriatrics and decreasing perioperative delirium, and pain management are covered, as well as issues about end-of-life care.

In this innovative new book, Steve Selvin provides readers with a clear understanding of intermediate biostatistical methods without advanced mathematics or statistical theory (for example, no Bayesian statistics, no causal inference, no linear algebra and only a slight hint of calculus). This text answers the important question: After a typical first-year course in statistical methods, what next?
Statistical Tools for Epidemiologic Research thoroughly explains not just how statistical data analysis works, but how the analysis is accomplished. From the basic foundation laid in the introduction, chapters gradually increase in sophistication with particular emphasis on regression techniques (logistic, Poisson, conditional logistic and log-linear) and then beyond to useful techniques that are not typically discussed in an applied context. Intuitive explanations richly supported with numerous examples produce an accessible presentation for readers interested in the analysis of data relevant to epidemiologic or medical research.

Fundamentals of Anaesthesia is the gold standard text for the Primary FRCA, encapsulating the basic principles of modern anaesthesia in one easily accessible volume. Written and edited by experts with extensive FRCA examination experience, this text deliberately blends the expertise of invited authors in an unrivalled consistency of style more akin to that of a single author text. All of the subject matter required to pass the exam is condensed into an easy-to-read format. This fully updated fourth edition includes new guidelines, an improved chapter structure, and a new section on clinical ultrasound. The generous use of summary boxes, bullet points, tables and diagrams creates a text that is clear, concise and easy to navigate. Each section covers one of the four components of the SOE. This is a unique revision aid for the Primary FRCA and an essential companion for all exam candidates.

This book is a comprehensive guide to Targeted Drug Delivery (TDD), also known as Intrathecal Drug Delivery (IDD), and offers an overview to this unique form of treatment. The medication is delivered by intrathecal pumps and is less common than some other techniques for interventional pain management, but is essential in conditions such as refractory pain, cancer pain, multifocal pain, severe spasticity, and in patients who are not candidates for surgical correction of their underlying condition. This book is the first source to describe both the optimal surgical implantation and patient management aspect of this therapy, and thus will be a valuable single reference guide for interventional radiologists, anesthesiologists, physiatrists, oncologists, neurologists, spine surgeons, palliative care physicians, and primary care physicians.

Launched on Oxford Medicine Online in 2012, with the full-text of eight Mayo Clinic Scientific Press (MCSP) print titles and a bank of multiple-choice questions, Mayo Clinic Toolkit provides a single location for resident, fellow, and practicing clinicians to undertake the self-testing necessary to prepare for, and pass, the Boards.
The Mayo Clinic Atlas of Regional Anesthesia and Ultrasound-Guided Nerve Blockade is a practical guide that vividly illustrates a systematic approach to regional anesthesia of the upper and lower extremity while providing a comprehensive overview of the fundamental principles of ultrasonography, relevant Sonoanatomy of the upper and lower extremity, and the technical skills necessary to become clinically proficient at ultrasound-guided regional anesthesia. With over 200 beautifully illustrated anatomic images that can be enlarged and downloaded to PowerPoint, the online version is essential reading for Board Exam preparation.
Highlights of The Mayo Clinic Toolkit include:
- Each title is presented in an enhanced format, allowing the enlargement and download of all figures and images, and linking to external sources referenced in the text.
- The multiple-choice questions are designed to mirror those in the Board exam for realistic preparation; they also link back to the relevant title, and allow the user to measure their development through the recording of practice-exam success.
- It can be accessed on a range of internet enabled devices, giving residents, fellows, and practicing clinicians the choice to study in locations which suit them
- Subscription lengths range from 1-month to a full year.
Combining two complimentary resource types into a single location, with enhancements to the print works, the flexibility to choose where and when to study, and the ability to monitor revision progress, Mayo Clinic Toolkit is truly the go-to site for Board preparation.

Topics: Perioperative Care of Patient with Chronic Opioid Dependence; Anesthesia for Sites Outside the OR; New Developments in Anesthesia Ventilators and Machines; Future of Clinical Research/Ethics in Human Experimentation; Perioperative Glucose Management; Inflammatory Response to Anesthesia and Ways to Attenuate; Chemical Dependence; Anesthesia for Awake Craniotomies; Hyperthermic Peritoneal Chemotherapy; ACGME Competencies; Renal Function Update; Professionalism; New Developments in Neonatal Resuscitation; Automated Anesthesia

This book comprehensively addresses the use of pulmonary function measurement for the evaluation, screening and timing of noninvasive mechanical ventilation (NIMV) from hospital to home care. To do so, it describes three clinical stages of NIMV support: before NIV, to detect early markers and determine whether NIV is appropriate; during NIV, to evaluate NIV response; and in long-term NIV support. Additionally, it assesses a range of complementary health care organizations (pulmonary function labs, pneumology wards, semi-intensive care units and home mechanical ventilation programs), techniques (chest physiotherapy/airway secretions, etc.) and applications. In closing, the book offers practical recommendations on how noninvasive ventilation and lung function measurement can improve outcomes and quality of life, making it a valuable resource for all specialists, e.g. intensivists and pneumologists, as well as anesthesiologists and therapists.