This interdisciplinary book consists of the proceedings of the Alexander Ivanovich Oparin lOOth Anniversary Conference, The Third Trieste Conference on Chemical Evolution, which took place at the International Centre for Theoretical Physics from 29 August till 2 September, 1994. A general overview of Oparin's life and work is followed by a review of Alfonso Herera, another pioneer in the studies of the origin of life. The subject matter is organized in ten sections corresponding to various aspects of our current understanding of the subject that was initiated by Oparin. These subjects were covered by fifty three speakers. There were sixty seven participants from a wide geographical distribution; twenty seven countries were represented. We have included the invited lecture of Professor Igor Kulaev, who was unable to be present at the conference for reasons beyond his control. The conference was generously supported by the International Centre for Theoretical Physics, the Commission of the European Communities, the International Centre for Genetic Engineering and Biotechnology, the International Centre for Science and High Technology, and UNESCO. Cyril Ponnamperuma, University of Maryland, U.S.A. Julian Chela-Flores, ICTP, Italy, and IDEA, Venezuela. xi FOREWORD As this volume was going to press we learnt of the untimely death of Cyril Ponnamperuma who died of cardiac arrest on December 20, 1994.

Ever since Darwin, scholars have noted that cultural entities such as languages, laws, firms and theories seem to 'evolve' through sequences of variation, selection and replication, in many ways just like living organisms. These essays consider whether this comparison is 'just a metaphor', or whether modern evolutionary theory can help us to understand the dynamics of different cultural domains.

The 'evolutionary paradigm of rationality' has a significant role to play throughout the human sciences, but raises complex issues in every cultural context where it is applied. By fostering discussion between scholars from a wide range of research traditions, this volume aims to influence the evolution of all of them.

This volume summarises the outcome of the 13th Workshop of the International Association of Phytoplankton Taxonomy and Ecology (IAP) on if, and if so under what conditions phytoplankton assemblages reach equilibrium in natural environments. Quite a number of ecological concepts use terms such as: ecological equilibrium, stability, steady-state, climax, stable state, etc. However, these ecological concepts often have been "translations" of scientific theories developed in physics or chemistry but they almost always lack scientific corroboration, the problem being that often these concepts remain vague and they are not formally defined. Here an attempt to formally recognize what "equilibrium" is in phytoplankton ecology is traced. The book also contains papers by leading scientists on the taxonomy of two selected key groups: cryptomonads and filamentous cyanoprokaryotes. This volume is addressed to all those involved in phytoplankton taxonomy and ecology and in ecology itself.

Wild emmer is the progenitor of most cultivated wheats and thus an important source of wheat improvement. This book draws the results from multidisciplinary studies on the ecological, genetic, genomic, agronomic, and evolutionary aspects of wild emmer, conducted at many labs around the world.It is divided into the following parts: Origin and Evolution of Wheat - Population Genetics of Wild Emmer Wheat at the Protein and DNA Levels - Genetic Resources of Wild Emmer for Wheat Improvement - Genome Organization and Genetic Mapping - Conclusions and Prospects.The authors describe the evolution of wild emmer as a model organism of a selfer in evolutionary biology, and its rich potential genetic resources for wheat improvement.

Timing, racing, combating, struggling and targeting are some actions through which cellular fate could be reflected and evaluated. Interaction between cell territory and environment occur during pre-embryonic, fetal development, and post-natal periods. What the researchers observe as the outcome of telomeres behavior is only the peak of an ice mountain within a stormy ocean. Cellular life depends on programmed behavior of telomeres, capable to surprise the cells. Telomeres provide an introduction to the history of our cells which govern the quality of life and status of health. Telomeres as the cooperative territory are capable of stabilizing the chromosomal territory. The status of telomeres reflects the key information, announcing the real age of individuals, and may be a valuable marker for prognosis and predicting cancer. Telomere territory is characterized with a multi-disciplinary manner. Therefore, this book is aimed to offer a wide range of chapters, hoping to be useful for diverse audiences, including hematologists-oncologists, radiotherapists, surgeons, cancer researchers, and all the sectors who affect the macro- and micro- environmental domains. Finally, telomeres are sensitive, cooperative, and trustable targets. It is worth to state that 'telomeres are messengers of NATURE', let's to know them as they are.

The ideal textbook for non-science majors, this lively and engaging introduction encourages students to ask questions, assess data critically and think like a scientist. Building on the success of the previous editions, Dinosaurs has been reorganised and extensively rewritten in response to instructor and student feedback. It continues to make science accessible and relevant through its clear explanations and extensive illustrations. Updated to reflect recent fossil discoveries and to include new taxa, the text guides students through the dinosaur groups, emphasising scientific concepts rather than presenting endless facts. It is grounded in the common language of modern evolutionary biology - phylogenetic systematics - so that students examine dinosaurs as professional paleontologists do. The key emerging theme of feathered dinosaurs, and the many implications of feathers, have been integrated throughout the book, highlighted by the inclusion of stunning new photographs in this beautifully illustrated text, now in full colour throughout.

Movement, dispersal, and migration on land, in the air, and in water, are pervading features of animal life. They are performed by a huge variety of organisms, from the smallest protozoans to the largest whales, and can extend over widely different distance scales, from the microscopic to global. Integrating the study of movement, dispersal, and migration is crucial for a detailed understanding of the spatial scale of adaptation, and for analysing the consequences of landscape and climate change as well as of invasive species. This novel book adopts a broad, cross-taxonomic approach to animal movement across both temporal and spatial scales, addressing how and why animals move, and in what ways they differ in their locomotion and navigation performance. Written by an integrated team of leading researchers, the book synthesizes our current knowledge of the genetics of movement, including gene flow and local adaptations, whilst providing a future perspective on how patterns of animal migration may change over time together with their potential evolutionary consequences. Novel technologies for tracking the movement of organisms across scales are also discussed, ranging from satellite devices for tracking global migrations to nanotechnology that can follow animals only a millimetre in size. Animal Movement Across Scales is particularly suitable for graduate level students taking courses in spatial animal ecology, animal migration, and 'movement ecology', as well as providing a source of fresh ideas and opinions for those already active within the field. It will also be of interest and use to a broader audience of professional biologists interested in animal movements and migrations.

Building on a range of disciplines - from biology and anthropology to philosophy and linguistics - this book draws on the expertise of leading names in the study of organic, mental and cultural codes brought together by the emerging discipline of biosemiotics. The book's 18 chapters present a range of experimental evidence which suggests that the genetic code was only the first in a long series of organic codes, and that it has been the appearance of new codes - organic, mental and cultural - that paved the way for the major transitions in the history of life. While the existence of many organic codes has been proposed since the 1980s, this volume represents the first multi-authored attempt to deal with the range of codes relevant to life, and to reveal the ubiquitous role of coding mechanisms in both organic and mental evolution. This creates the conditions for a synthesis of biology and linguistics that finally overcomes the old divide between nature and culture.

Plant-herbivore interactions are a central topic in evolutionary ecology. Historically, their study has been a cornerstone for coevolutionary theory. Starting from classic ecological studies at the phenotypic level, it has since expanded to molecular and genomic approaches. After a historical perspective, the book's subsequent chapters cover a wide range of topics: from populations to ecosystems; plant- and herbivore-focused studies; in natural and in man-modified ecosystems; and both micro- and macro-evolutionary levels. All chapters include valuable background information and empirical evidence. Given its scope, the book will be of interest to both students and researchers, and will hopefully stimulate further research in this exciting field of evolutionary biology.

Research in whale origins is now in an explosive phase, with a cascade of discoveries adding to our understanding of the evolutionary pattern and a suite of new techniques being applied to address new questions. The objective of this volume is to provide a snapshot of this explosion. The volume paints the scene with a broad brush. Taken together the chapters clearly indicate that cetacean origins is a field that is dynamic, multidisciplinary, and that the end of the explosive phase is not in sight.

Despite decades of work in evolutionary algorithms, there remains a lot of uncertainty as to when it is beneficial or detrimental to use recombination or mutation. This book provides a characterization of the roles that recombination and mutation play in evolutionary algorithms. It integrates prior theoretical work and introduces new theoretical techniques for studying evolutionary algorithms. An aggregation algorithm for Markov chains is introduced which is useful for studying not only evolutionary algorithms specifically, but also complex systems in general. Practical consequences of the theory are explored and a novel method for comparing search and optimization algorithms is introduced. A focus on discrete rather than real-valued representations allows the book to bridge multiple communities, including evolutionary biologists and population geneticists.

This book is about morphogenesis as the genesis of forms. It is not restricted to plants growing from seed or animals developing from an embryo (although these do supply the most abundant examples) but also addresses kindred processes, from inorganic to social to biomorphic technology. It is about our morphogenetic universe: unplanned, unfair and frustratingly complicated but benevolent in allowing us to emerge, survive, and inquire into its laws.

There is hardly any university, college, or even high school left where they do not teach Darwinism-and rightly so. Yet, most of these places do more preaching than teaching. They teach more than they should, and at the same time, they teach less than they should. Most books on Darwinism are either oriented on biology or philosophy, but this book tries to combine both approaches, so it explains the biological aspects for (future) philosophers as well as the philosophical aspects for (future) biologists. It leaves Darwinism intact, but removes the "sting" that many of its opponents dislike. In what Verschuuren calls "The Good" parts of Darwin's legacy, the author explores what Darwin's great contributions are to the study and theory of evolution. At the same time, the book will also delve into the areas where Darwin's thoughts were not so perfect or even wrong, especially in a philosophical sense - "The Not So Good" parts of his legacy. Almost all books on the philosophy of biology, and neo-Darwinism in particular, were born in the cradle of logical positivism or linguistic analysis. This book, on the other hand, tries to cross the border between the physical and the meta-physical.

What can economics, the natural and the social sciences learn from each other in better understanding complex forms of change? How far can models, methodologies or metaphors that have been used successfully in one disciplinary field be 'exported' and meaningfully applied to other fields? Distinguished researchers from across the globe assess, in a rare example of successful cross-disciplinary engagement, the explanatory power of chaos theory, new evolutionary theory, path dependency, neo-institutional economics, multiple modernities and historical institutionalism. The book provides an exciting panorama of state of the art thinking and new avenues to combining the power of various traditions of thought.

Since its inception, paleoanthropology has been closely wedded to the idea that big-game hunting by our hominin ancestors arose, first and foremost, as a means for acquiring energy and vital nutrients. This assumption has rarely been questioned, and seems intuitively obvious-meat is a nutrient-rich food with the ideal array of amino acids, and big animals provide meat in large, convenient packages. Through new research, the author of this volume provides a strong argument that the primary goals of big-game hunting were actually social and political-increasing hunter's prestige and standing-and that the nutritional component was just an added bonus.
Through a comprehensive, interdisciplinary research approach, the author examines the historical and current perceptions of protein as an important nutrient source, the biological impact of a high-protein diet and the evidence of this in the archaeological record, and provides a compelling reexamination of this long-held conclusion. This volume will be of interest to researchers in Archaeology, Evolutionary Biology, and Paleoanthropology, particularly those studying diet and nutrition.

This book challenges the assumption that morphological data are inherently unsuitable for phylogeny reconstruction, argues that both molecular and morphological phylogenies should play a major role in systematics, and provides the most comprehensive review of the comparative anatomy, homologies and evolution of the head, neck, pectoral and upper limb muscles of primates. Chapters 1 and 2 provide an introduction to the main aims and methodology of the book. Chapters 3 and 4 and Appendices I and II present the data obtained from dissections of the head, neck, pectoral and upper limb muscles of representative members of all the major primate groups including modern humans, and compare these data with the information available in the literature. Appendices I and II provide detailed textual (attachments, innervation, function, variations and synonyms) and visual (high quality photographs) information about each muscle for the primate taxa included in the cladistic study of Chapter 3, thus providing the first comprehensive and up to date overview of the comparative anatomy of the head, neck, pectoral and upper limb muscles of primates. The most parsimonious tree obtained from the cladistic analysis of 166 head, neck, pectoral and upper limb muscle characters in 18 primate genera, and in representatives of the Scandentia, Dermoptera and Rodentia, is fully congruent with the evolutionary molecular tree of Primates, thus supporting the idea that muscle characters are particularly useful to infer phylogenies. The combined anatomical materials provided in this book point out that modern humans have fewer head, neck, pectoral and upper limb muscles than most other living primates, but are consistent with the proposal that facial and vocal communication and specialized thumb movements have probably played an important role in recent human evolution. This book will be of interest to primatologists, comparative anatomists, functional morphologists, zoologists, physical anthropologists, and systematicians, as well as to medical students, physicians and researchers interested in understanding the origin, evolution, homology and variations of the muscles of modern humans. Contains 132 color plates.

The study of religion by the humanities and social sciences has become receptive for an evolutionary perspective. Some proposals model the evolution of religion in Darwinian terms, or construct a synergy between biological and non-Darwinian processes. The results, however, have not yet become truly interdisciplinary. The biological theory of evolution in form of the Extended Evolutionary Synthesis (EES) is only sparsely represented in theories published so far by scholars of religion. Therefore this book reverses the line of view and asks how their results assort with evolutionary biology: How can the subject area "religion" integrated into behavioral biology? How is theory building affected by the asymmetry between the scarce empirical knowledge of prehistoric religion, and the body of knowledge about extant and historic religions? How does hominin evolution in general relate to the evolution of religion? Are there evolutionary pre-adaptations? Subsequent versions of evolutionary biology from the original Darwinism to EES are used in interdisciplinary constructs. Can they be integrated into a comprehensive theory? The biological concept most often used is co-evolution, in form of a gene-culture co-evolution. However, the term denotes a process different from biological co-evolution. Important EES concepts do not appear in present models of religious evolution: e.g. neutral evolution, evolutionary drift, evolutionary constraints etc. How to include them into an interdisciplinary approach? Does the cognitive science of religion (CSR) harmonize with behavioral biology and the brain sciences? Religion as part of human culture is supported by a complex, multi-level behavioral system. How can it be modeled scientifically? The book addresses graduate students and researchers concerned about the scientific study of religion, and biologist interested in interdisciplinary theory building in the field.

Many multicellular animals do not require oxygen to live but respire anaerobically. Some of these have adapted to "hostile" environments, such as sulphide rich habitats, others live as parasites within host organisms, while others still can perhaps be said to look back on the early days of life on earth before anaerobic respiration had evolved. This comprehensive volume lays out detailed summaries of the strategies for anero- or anoxy-biosis employed by each major group of metazoan animals. It begins with a description of the physical chemistry of oxygen, followed by a dissertation on the perils - and opportunities - created for life by oxygen derived free radicals. It moves on to examine the geochronology of the accumulation of oxygen in the environment and to analyze the first explosive adaptive radiation of the Metazoa in the Ediacarian and early Cambrian. It then explores the biochemistry of sulphide dependent organisms and follows with a detailed account of the evolution of fumarate reductase, the enzyme system that makes anaerobiosis possible in many invertebrate phyla. After the survey of invertebrate phyla, there is a chapter concerned with the strategies adopted by various vertebrates for anoxybiotic survival, and one on the dependence of many vertebrates on anaerobic processes. The contributors are authorities from around the world. The approach to the subject is an evolutionary one, drawing from many fields in biology. This book should be of interest to parasitologists, comparative biochemists, evolutionary biologists, palaeontologists and geochemists.

The present book gives an overview on the similarities and differences of the various translation systems. Moreover, it highlights the mechanisms and control of translation in mitochondria and other organelles such as chloroplasts, plastids and apicoplasts in different organisms. Lastly, it offers an outlook on future developments and applications that might be made possible by a better understanding of translation in mitochondria and other organelles. "

Evolution: The Basics is an engaging introduction to the history, development and science of the theory of evolution. Beginning pre-Darwin and concluding with the latest research and controversies, readers are introduced to the origins of the idea of evolution, the ways in which it has developed and been adapted over time and the science underpinning it all. Topics addressed include:

? early theories of evolution
? the impact of Darwin's On the Origin of Species
? the discovery of genetics and Mendel's experiments
? molecular evolution and the discovery of DNA
? the expansion of life and the persistence of disease
? revisiting evolutionary ethics and the development of empathy.

Evolution: The Basics examines the role of evolution in current debates and discusses the possible future developments in the field. This book is invaluable reading for all students and individuals seeking to understand the wide ranging sphere of evolutionary theory.

Chronic inflammation is one of the major pathological bases manifesting the development of gastric cancers, hepatitis and hepatocellular carcinoma, cervical cancer, ulcerative colitis and colorectal cancer [1]. Microbial infections, viral infections and autoimmune responses can lead to chronic inflammation-associated cancer formation. Human herpesviruses, such as human cytomegalovirus (HCMV) and Kaposi sarcoma herpesvirus (KSHV) are known to be associated with tumorigenesis and tumor progression. HCMV infection potentiates malignancies of colon cancer and malignant glioma [2,3]. KSHV was initially discovered from Kaposi's sarcoma lesion of an AIDS patient [4]. It was subsequently discovered that KSHV contributed to the pathogenesis of KS, primary effusion lymphoma [5] and lymphoproliferative disorder multicentric Castleman's disease. Emerging evidence shows that herpesvirus infection interferes or inhibits host cell immune defense and maintains a tumor-promoting microenvironment by expressing virulent homologues of host cell proteins that disturb normal cell cycle progression and leads to apoptosis of the host cells. For example, cellular growth and transformation are induced by viral-encoded homologues of cytokines, chemokines or chemokine receptors [6]. The constitutive expression of viral chemokine GPCRs triggers prolonged activation of G protein signaling and eventually becomes the major inputs for chronic leukocyte infiltration and cancer development. GPCRs can serve as proto-oncogenes since overexpression of various wild type GPCRs can transform cells in the presence of their specific ligands. Mutations on GPCRs may result in constitutive signaling and oncogenesis [7]. Naturally occurring mutations in GPCRs have been identified in human tumors [8,9].

Originally published in 1969, the aim of this book is to tell the story of the major discoveries which have been made and the attitude of the world at large to these discoveries during the ten decades since Darwin published On the Origin of Species in 1859. For anyone interested in man's past and in understanding the significance of each new discovery relating to human evolution, this reissue will be of great value.