This book provides a comprehensive overview of the design, generation and characterization of minimal cell systems. Written by leading experts, it presents an in-depth analysis of the current issues and challenges in the field, including recent advances in the generation and characterization of reduced-genome strains generated from model organisms with relevance in biotechnology, and basic research such as Escherichia coli, Corynebacterium glutamicum and yeast. It also discusses methodologies, such as bottom-up and top-down genome minimization strategies, as well as novel analytical and experimental approaches to characterize and generate minimal cells. Lastly, it presents the latest research related to minimal cells of serveral microorganisms, e.g. Bacillus subtilis. The design of biological systems for biotechnological purposes employs strategies aimed at optimizing specific tasks. This approach is based on enhancing certain biological functions while reducing other capacities that are not required or that could be detrimental to the desired objective. A highly optimized cell factory would be expected to have only the capacity for reproduction and for performing the expected task. Such a hypothetical organism would be considered a minimal cell. At present, numerous research groups in academia and industry are exploring the theoretical and practical implications of constructing and using minimal cells and are providing valuable fundamental insights into the characteristics of minimal genomes, leading to an understanding of the essential gene set. In addition, research in this field is providing valuable information on the physiology of minimal cells and their utilization as a biological chassis to which useful biotechnological functions can be added.

Origins: Genesis, Evolution and Biodiversity of Microbial Life in the Universe is the sixth unit of the book series Cellular Origins, Life in Extreme Habitats and Astrobiology (COLE) edited by Joseph Seckbach. In this book forty eminent scientists review their studies in the fields of Life from the beginning to the "Fact of Life." The history of Origin of Life and Astrobiology is well covered by these authors. Reviews cover the standard and alternative scenarios of the genesis of Life, while the chapters of "The First Cells" leading to the biodiversity and extremophiles of microbial Life. Among these extremophiles are the microbes living in the Life's limits, such as in high temperature, psychrophilic, UV radiation, and halophilic environments. The origin and history of Martian water is discussed followed by the possible biogeochemistry inside Titan. This new field of Astrobiology has been presented, from comets as a source of materials and Life on earth to the space for last Frontiers.

Over time the complex idea of "species" has evolved, yet its meaning is far from resolved. This comprehensive work is a fresh look at an idea central to the field of biology by tracing its history from antiquity to today. Species is a benchmark exploration and clarification of a concept fundamental to the past, present, and future of the natural sciences. In this edition, a section is added on the debate over species since the time of the New Synthesis, and brings the book up to date. A section on recent philosophical debates over species has also been added. This edition is better suited non-specialists in philosophy, so that it will be of greater use for scientists wishing to understand how the notion came to be that living organisms form species. Key Selling Features: Covers the philosophical and historical development of the concept of "species" Documents that variation was recognized by pre-Darwinian scholars Includes a section on the debates since the time of the New Synthesis Better suited to non-philosophers

Ultrasocial argues that rather than environmental destruction and extreme inequality being due to human nature, they are the result of the adoption of agriculture by our ancestors. Human economy has become an ultrasocial superorganism (similar to an ant or termite colony), with the requirements of superorganism taking precedence over the individuals within it. Human society is now an autonomous, highly integrated network of technologies, institutions, and belief systems dedicated to the expansion of economic production. Recognizing this allows a radically new interpretation of free market and neoliberal ideology which - far from advocating personal freedom - leads to sacrificing the well-being of individuals for the benefit of the global market. Ultrasocial is a fascinating exploration of what this means for the future direction of the humanity: can we forge a better, more egalitarian, and sustainable future by changing this socio-economic - and ultimately destructive - path? Gowdy explores how this might be achieved.

Encyclopedia of Evolutionary Biology, Four Volume Set is the definitive go-to reference in the field of evolutionary biology. It provides a fully comprehensive review of the field in an easy to search structure. Under the collective leadership of fifteen distinguished section editors, it is comprised of articles written by leading experts in the field, providing a full review of the current status of each topic. The articles are up-to-date and fully illustrated with in-text references that allow readers to easily access primary literature. While all entries are authoritative and valuable to those with advanced understanding of evolutionary biology, they are also intended to be accessible to both advanced undergraduate and graduate students. Broad topics include the history of evolutionary biology, population genetics, quantitative genetics; speciation, life history evolution, evolution of sex and mating systems, evolutionary biogeography, evolutionary developmental biology, molecular and genome evolution, coevolution, phylogenetic methods, microbial evolution, diversification of plants and fungi, diversification of animals, and applied evolution.

This book attempts to develop a Marxist theory of the human individual. It contends that the standard description of the human as a bio-psycho-social being is fundamentally deficient as it doesn't specify which of these attributes is the determining one. As long as this is not done, the real nature of humanity cannot be uncovered.

'Brilliant, eye-opening, and absolutely inspiring - and a riveting read.' Cass Sunstein, author of How Change Happens and co-author of Nudge What is the secret to humanity's evolutionary success? Could it be our strength, our intellect... or something much nicer? From the authors of New York Times bestseller The Genius of Dogs comes a powerful new idea about how 'friendliness' is the key factor in the flourishing of our species. Hare and Woods present an elegant new theory called self-domestication, looking at examples of co-operation and empathy and what this can tell us about the evolutionary success of Homo sapiens...

Nicola Hoggard Creegan offers a compelling examination of the problem of evil in the context of animal suffering, disease, and extinction and the violence of the evolutionary process. Using the parable of the wheat and the tares as a hermeneutical lens for understanding the tragedy and beauty of evolutionary history, she shows how evolutionary theory has deconstructed the primary theodicy of historic Christianity--the Adamic fall--while scientific research on animals has increased appreciation of animal sentience and capacity for suffering. Animal Suffering and the Problem of Evil responds to this new theodic challenge. Hoggard Creegan argues that nature can be understood as an interrelated mix of the perfect and the corrupted: the wheat and the tares. At times the good is glimpsed, but never easily nor unequivocally. She then argues that humans are not to blame for all evil because so much evil preceded human becoming. Finally, she demonstrates that faith requires a confidence in the visibility of the work of God in nature, regardless of how infinitely subtle and almost hidden it is, affirming that there are ways of perceiving the evolutionary process beyond that 'nature is red in tooth and claw.'

An instant bestseller in 1859, few books have had such a revolutionary impact and left such a lasting impression as On the Origin of Species. Possibly the most important and challenging scientific book ever published, Darwin's language remains surprisingly modern and direct and is presented here in a faithful facsimile edition. The text is taken from the second edition (1860), which is the same as the first except for some minor corrections and so is the purest distillation of Darwin's original vision. It includes a new foreword by David Williams, Researcher at the Natural History Museum,and the introductory appendix, An Historical Sketch of the Recent Progress of Opinion on the Origin, which first appeared in the third edition (1861). As such it is an ideal scholarly resource as well an attractive and excellent value edition for the general reader.

This book offers a thorough reanalysis of Charles Darwin's Origin of Species, which for many people represents the work that alone gave rise to evolutionism. Of course, scholars today know better than that. Yet, few resist the temptation of turning to the Origin in order to support it or reject it in light of their own work. Apparently, Darwin fills the mythical role of a founding figure that must either be invoked or repudiated. The book is an invitation to move beyond what is currently expected of Darwin's magnum opus. Once the rhetorical varnish of Darwin's discourses is removed, one discovers a work of remarkably indecisive conclusions. The book comprises two main theses: (1) The Origin of Species never remotely achieved the theoretical unity to which it is often credited. Rather, Darwin was overwhelmed by a host of phenomena that could not fit into his narrow conceptual framework. (2) In the Origin of Species, Darwin failed at completing the full conversion to evolutionism. Carrying many ill-designed intellectual tools of the 17th and 18th centuries, Darwin merely promoted a special brand of evolutionism, one that prevented him from taking the decisive steps toward an open and modern evolutionism. It makes an interesting read for biologists, historians and philosophers alike.

'Steve Brusatte, the author of The Rise and Fall of the Dinosaurs, brings mammals out from the shadow of their more showy predecessors in a beautifully written book that . . . makes the case for them as creatures who are just as engaging as dinosaurs.' - The Sunday Times, 'Best Books For Summer' 'In this terrific new book, Steve Brusatte . . . brings well-known extinct species, the sabre-toothed tigers and the woolly mammoths, thrillingly back to life' - The Times The passing of the age of the dinosaurs allowed mammals to become ascendant. But mammals have a much deeper history. They - or, more precisely, we - originated around the same time as the dinosaurs, over 200 million years ago; mammal roots lie even further back, some 325 million years. Over these immense stretches of geological time, mammals developed their trademark features: hair, keen senses of smell and hearing, big brains and sharp intelligence, fast growth and warm-blooded metabolism, a distinctive line-up of teeth (canines, incisors, premolars, molars), mammary glands that mothers use to nourish their babies with milk, qualities that have underlain their success story. Out of this long and rich evolutionary history came the mammals of today, including our own species and our closest cousins. But today's 6,000 mammal species - the egg-laying monotremes including the platypus, marsupials such as kangaroos and koalas that raise their tiny babies in pouches, and placentals like us, who give birth to well-developed young - are simply the few survivors of a once verdant family tree, which has been pruned both by time and mass extinctions. In The Rise and Reign of the Mammals, palaeontologist Steve Brusatte weaves together the history and evolution of our mammal forebears with stories of the scientists whose fieldwork and discoveries underlie our knowledge, both of iconic mammals like the mammoths and sabre-toothed tigers of which we have all heard, and of fascinating species that few of us are aware of. For what we see today is but a very limited range of the mammals that have existed; in this fascinating and ground-breaking book, Steve Brusatte tells their - and our - story.

This volume explains the key ideas, questions and methods involved in studying the hidden world of vibrational communication in animals. The authors dispel the notion that this form of communication is difficult to study and show how vibrational signaling is a key to social interactions in species that live in contact with a substrate, whether it be a grassy lawn, a rippling stream or a tropical forest canopy. This ancient and widespread form of social exchange is also remarkably understudied. A frontier in animal behavior, it offers unparalleled opportunities for discovery and for addressing general questions in communication and social evolution. In addition to reviews of advances made in the study of several animal taxa, this volume also explores topicssuch as vibrational communication networks, the interaction of acoustic and vibrational communication, the history of the field, the evolution of signal production and reception and establishing a common vocabulary."

The human foot is a unique and defining characteristic of our anatomy. Most primates have grasping, prehensile feet, whereas the human foot stands out as a powerful non-grasping propulsive lever that is central to our evolution as adept bipedal walkers and runners and defines our lineage. Very few books have compiled and evaluated key research on the primate foot and provided a perspective on what we know and what we still need to know. This book serves as an essential companion to "The Evolution of the Primate Hand" volume, also in the Developments in Primatology series. This book includes chapters written by experts in the field of morphology and mechanics of the primate foot, the role of the foot in different aspects of primate locomotion (including but not limited to human bipedalism), the "hard evidence" of primate foot evolution including fossil foot bones and fossil footprints, and the relevance of our foot's evolutionary history to modern human foot pathology. This volume addresses three fundamental questions: (1) What makes the human foot so different from that of other primates? (2) How does the anatomy, biomechanics, and ecological context of the foot and foot use differ among primates and why? (3) how did foot anatomy and function change throughout primate and human evolution, and why is this evolutionary history relevant in clinical contexts today? This co-edited volume, which relies on the insights of leading scholars in primate foot anatomy and evolution provides for the first time a comprehensive review and scholarly discussion of the primate foot from multiple perspectives. It is accessible to readers at different levels of inquiry (e.g., undergraduate/graduate students, postdoctoral research, other scholars outside of biological anthropology). This volume provides an all-in-one resource for research on the comparative and functional morphology and evolution of the primate foot.

Natural selection, as introduced by Charles Darwin in the Origin of Species (1859), has always been a topic of great conceptual and empirical interest. This book puts Darwin's theory of evolution in historical context showing that, in important respects, his central mechanism of natural selection gives the clue to understanding the nature of organisms. Natural selection has important implications, not just for the understanding of life's history - single-celled organism to man - but also for our understanding of contemporary social norms, as well as the nature of religious belief. The book is written in clear, non-technical language, appealing not just to philosophers, historians, and biologists, but also to general readers who find thinking about important issues both challenging and exciting.

Up until now, there has been no explanation of how the outer layers of human behavior helped drive the evolution of ancient reptiles into modern-day humans. How did behavioral phenomena such as play, learning by copying, language, REM sleep, and storytelling influence the development of humanity as a whole?

The development of play was particularly important in the evolutionary process, as it provided the bridge between the instinctive brains of reptiles to the powerful brains of birds and mammals. Play, however, is just one factor that can help explain evolution and the development of human behavior.

In this book, you'll consider a gamut of issues, including Evolutionary stages The paradox of animals that feed on animals The importance and repercussions of copy-learning Primitive games The emergence of sleep The scientific community needs to think in new ways to accurately look at human evolutionary history. Take that leap, and consider new explanations of old behavior as you read The Evolutionary Origin of Human Behavior: How Play and Evolution Carried Us from Our Reptile Predecessors to the Storytellers We Are.

This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, phenomes and epigenomes. The book's respective chapters address a range of topics, from the serendipitous emergence of the pan-genome concept and its impacts on the fields of microbiology, vaccinology and antimicrobial resistance, to the study of microbial communities, bioinformatic applications and mathematical models that tie in with complex systems and economic theory. Given its scope, the book will appeal to a broad readership interested in population dynamics, evolutionary biology and genomics.

Codon-based models of evolution are a relatively new addition to the toolkit of computational biologists, and in recent years remarkable progress has been made in this area. The study of evolution at the codon level captures information contained in both amino acid and synonymous DNA substitutions. By combining these two types of information, codon analyses are more powerful than those of either amino acid or DNA evolution alone. This is a clear benefit for most evolutionary analyses, including phylogenetic reconstruction, detection of selection, ancestral sequence reconstruction, and alignment of coding DNA. Despite the theoretical advantages of codon based models, their relative complexity delayed their widespread use. Only in recent years, when large-scale sequencing projects produced sufficient genomic data and computational power increased, did their usage become more common. In Codon Evolution, leading researchers in the field of molecular evolution provide the latest insights from codon-based analyses of genetic sequences. The first part of the book provides comprehensive coverage of the developments of various types of codon substitution models such as parametric and empirical models used in maximum likelihood as well as Bayesian frameworks. Subsequent chapters examine the use of codon models to infer selection and other applications of codon models to biological systems. The second part of the book focuses on codon usage bias. Both the underlying mechanisms as well as current methods to analyse codon usage bias are presented.

"Fascinating and exhilarating-Sean B. Carroll at his very best."-Bill Bryson, author of The Body: A Guide for Occupants From acclaimed writer and biologist Sean B. Carroll, a rollicking, awe-inspiring story of the surprising power of chance in our lives and the world Why is the world the way it is? How did we get here? Does everything happen for a reason or are some things left to chance? Philosophers and theologians have pondered these questions for millennia, but startling scientific discoveries over the past half century are revealing that we live in a world driven by chance. A Series of Fortunate Events tells the story of the awesome power of chance and how it is the surprising source of all the beauty and diversity in the living world. Like every other species, we humans are here by accident. But it is shocking just how many things-any of which might never have occurred-had to happen in certain ways for any of us to exist. From an extremely improbable asteroid impact, to the wild gyrations of the Ice Age, to invisible accidents in our parents' gonads, we are all here through an astonishing series of fortunate events. And chance continues to reign every day over the razor-thin line between our life and death. This is a relatively small book about a really big idea. It is also a spirited tale. Drawing inspiration from Monty Python, Kurt Vonnegut, and other great thinkers, and crafted by one of today's most accomplished science storytellers, A Series of Fortunate Events is an irresistibly entertaining and thought-provoking account of one of the most important but least appreciated facts of life.

This new and significantly updated authored dictionary is a unique glossary of paleontological terms, taxa, localities, and concepts. It focuses primarily on identifying the most significant groups of fossil animals and plants in relation to their evolution and phylogeny. It also focuses on mass extinctions, on taxa that are problematic in some significant way, on the principal fossil-Lagerstatten of the world, and on historical turning points marked by index fossils. Although there are many current resources on the subject, none contains an accurate representation of the paleontological lexicon. Although well aware that the fast-changing field of paleontology will always defy any attempt at complete description, the author has attempted to provide an accurate and comprehensive set of about 4,000 entries that will be useful to professionals as well as to general readers of scientific literature without a background in paleontology.

________________ WINNER OF THE 2015 PULITZER PRIZE FOR GENERAL NON-FICTION ________________ 'An invaluable contribution to our understanding of present circumstances, just as the paradigm shift she calls for is sorely needed' - Al Gore, New York Times 'Compelling ... It is a disquieting tale, related with rigour and restraint by Kolbert' - Observer 'Passionate ... This is the big story of our age' - Sunday Times ________________ A major book about the future of the world, blending natural history, field reporting and the history of ideas and into a powerful account of the mass extinction happening today Over the last half a billion years, there have been five mass extinctions of life on earth. Scientists around the world are currently monitoring the sixth, predicted to be the most devastating extinction event since the asteroid impact that wiped out the dinosaurs. Elizabeth Kolbert combines brilliant field reporting, the history of ideas and the work of geologists, botanists and marine biologists to tell the gripping stories of a dozen species - including the Panamanian golden frog and the Sumatran rhino - some already gone, others at the point of vanishing. The sixth extinction is likely to be mankind's most lasting legacy and Elizabeth Kolbert's book urgently compels us to rethink the fundamental question of what it means to be human.