Recent advances in our understanding of the fundamental role of bioactive lipids in normal and abnormal physiology was the theme of the XVlth International Spring Sympo- 6-9, 1996 at the George Washington University School sium on Health Sciences held on May of Medicine in Washington, D.C. Over 250 participants shared their latest findings on fundamental mechanisms in lipid metabolism, transport, and signal transduction. Most of the papers presented at the plenary sessions have been collected in this volume, which is divided into seven parts. The focus of Part I is on the new roles that fatty acids and esters play in cellular function. These activities include regulation of gene expression, control of eicosanoid-me- diated responses, and intracellular calcium sequestration. Most biological effects of fatty acids, esters, and phospholipids are transmitted via the interaction of these lipid molecules with specific lipid binding proteins. The chapters in Part II detail the involvement of these in the transport of fatty acids, fatty acyl CoA esters, and phospholipids, and in the proteins modulation of the fatty acid-induced activation of the peroxisome proliferator-activated receptors. The study of arachidonic acid metabolism continues to be the subject of intense interest and research. A number of studies in Part III deal with the substantial differences between the constitutive prostaglandin H synthase isozyme (PGHS-l or COX-I) and the inducible form PGHS-2 (COX-2) regarding compartmentation, control, and expression.

Biological nitrogen fixation (BNF) - the conversion of molecular nitrogen into ammonia - is one of the most important reactions in ecology and agriculture. It is performed exclusively by microbes (prokaryotes) that live in symbiosis with plants. This book summarizes the latest research on this reaction, the participating microbes and the genetics of how their relevant genes could be transferred into the plants. In the light of a more sustainable and less ecologically damaging agriculture, this is becoming an increasingly pressing issue.

Morphometrical differentiation 63 Prediction of breeding origin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 68 Body mass 69 Primary moult 69 Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69 The taxonomy of the Eurasian Golden Plover 69 The existence of a partial breast-feather moult during breeding 69 Morphometrical differentiation between both sexes . . . . . . . . . . . . . . . . . . . . . . . . 70 The occurrence of primary moult on the breeding grounds 70 Summary 70 6 Grey Plover - Pluvialis squatarola 71 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73 Morphometrical differentiation 77 Prediction of breeding origin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 80 Accuracy 81 Exclusivity 81 Contact zones . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 82 Body mass 85 Primary moult 85 Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 86 The taxonomy of the Grey Plover . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 86 Small size at northern latitudes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 87 Morphometrical variation in the Palearctic 87 Summary 87 7 Red Knot - Calidris canutus . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 89 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 91 Morphometrical differentiation 93 Prediction of breeding origin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99 Accuracy 99 Exclusivity 101 Contact zones . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 102 Body mass 102 Primary moult 103 Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 103 of the Knot . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 103 The taxonomy Is the knot breeding in Yakutia? 106 Different degrees of geographical variation in the d'd' and !f!f 106 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 107 8 Sanderling - Calidris alba 109 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 111 Morphometrical differentiation 111 Prediction of breeding origin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 116 Accuracy 116 Exclusivity 118 Contact zones . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 118 Body mass 118 Primary moult 118 Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 118 The taxonomy of the Sanderling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 118 Sexing Sanderlings 119 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 119 VI 9 Curlew Sandpiper - Calidris ferruginea 121 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 123 Morphometrical differentiation 123 Prediction of a bird's sex . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 127 Accuracy 127 Exclusivity 127 Body mass 127 Primary moult 127 Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 127 The taxonomy of the Curlew Sandpiper 127 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

etween 1772 and 1799, Dominique Chaix wrote 170 letters to Dominique Villars. B None of the letters that Vtllars wrote in response have survived, and there is evidence to indicate that Chaix simply did not retain incoming letters once they had served their informative purpose. Villars, blessed with more ample facilities, kept incoming letters; and those from Chaix are now preserved in the Bibliotheque Municipale de Grenoble in three volumes under the number RI0073. A transcription of them for public use was made earlier in this century under the supervision of Georges de Manteyer [Georges-Barthelemy-Marie Pinet de Manteyer] when he was archivist of the Department of Hautes-Alpes. I am gready indebted to Mme Marie-Fran~ise Bois-Delatte, Conservateur des Fonds Dauphinoise at the Bibliotheque Municipale d'Etude et d'lnformation in Grenoble, not merely for making these letters available to me, but for her eagerness to see someone take an interest in Dauphinois botanists. I met a similar friendly interest at the Archives du Departement des Hautes-Alpes in Gap. I thank M. Pierre-Yves Playoust, Directeur des Services, and members of his archival staff for the cordial assistance in my search for materials documenting the career of the abbe Chaix. I am also obligated to the Hunt Institute for Botanical Documentation at Carnegie Mellon University in Pittsburgh for providing me photocopies of Villars' letters in their Allioni collection. They relate to the composition of a flora for Dauphine and are revealing of Villars' character.

This book contains the majority of the presentations of the Second International Symposium on the Biology of Root Formation and Development that was hcld in Jerusa lem, Israel, June 23---28, 1996. Following the First Symposium on the Biology of Adventi tious Root Formation, held in Dallas. USA, 1993, we perceived the need to include all kinds of roots, not only the shoot-borne ones. The endogenous signals that control root formation. and the subsequent growth and development processes, are very much alike, re gardless of the sites and sources of origin of the roots. Therefore, we included in the Sec ond Symposium contributions on both shoot-borne (i.e., adventitious) roots and root-borne (i.e., lateral) roots. Plant roots have remained an exciting and an intriguing field of sciencc. During thc years that followed the first symposium, an exceptional proliferation of interest in root biology has developed, associated with the intensive research activity in this field and the contemporary developments in the understanding of root function and development. New methods have been applied, and old ideas and interprctations werc rccxamined. Alto gether, it became necessary to update our viewpoints and to expand them.

Atmospheric carbon dioxide concentration has increased globally from about 280 ppm before the Industrial Revolution (Pearman 1988) to about 353 ppm in 1990. That increase, and the continuing increase at a rate of about 1.5 ppm per annum, owing mainly to fossil fuel burning, is likely to cause change in climate, in primary productivity of terrestrial vegetation (managed and unmanaged), and in the degree of net sequestration of atmospheric CO into organic form. The quantitative role 2 of the latter in attenuating the increase in atmospheric CO concentration itself is 2 an important but uncertain element of the global carbon-cycle models that are required to predict future increases of atmospheric CO concentration. 2 In my experience in workshops and other multidisciplinary gatherings, argument arises in discussion of this topic among different groups of scientists such as bioclimatologists, plant physiologists, biogeochemists and ecologists. Plant concentration physiologists are often impressed by the positive effect of higher CO 2 on plant growth under experimental controlled environments and argue that this would be at least partly expressed in the field for many species and communities.

The quality of human life has been maintained and enhanced for generations by the use of trees and their products. In recent years, ever rising human population growth has put tremendous pressure on trees and tree products; growing awareness of the potential of previously un exploited tree resources and environmental pollution have both accelerated development of new technologies for tree propagation, breeding and improvement. Biotechnology of trees may be the answer to solve the problems which cannot be solved by conventional breeding methods. The combination of biotechnology and conventional methods such as plant propagation and breeding may be a novel approach to improving and multiplying in large number the trees and woody plants. So far, plant tissue culture technology has largely been exploited in the propagation of ornamental plants, especially foliage house plants, by com- mercial companies. Generally, tissue culture of woody plants has been recal- citrant. However, limited success has been achieved in tissue culture of angiosperm and gymnosperm woody plants. A number of recent reports on somatic embryogenesis in woody plants such as Norway spruce (Picea abies), Loblolly pine (Pinus taeda), Sandalwood (Santalum album), Citrus, Mango (Mangifera indica), etc. offer a ray of hope of: (a) inexpensive clonal propa- gation for large-scale production of plants or "emblings" or "somatic embryo plants"; (b) protoplast work; (c) cryopreservation; (d) genetic transforma- tion; and (e) artificial or manufactured seed production.

With one volume each year, this series keeps scientists and advanced students informed of the latest developments and results in all areas of the plant sciences.
The present volume includes reviews on genetics, cell biology, physiology, comparative morphology, systematics, ecology, and vegetation science.

Tea is a unique crop and, incidentally, a very interesting and attractive one. The tea bush, its cultivation and harvesting do not fit into any typical cropping pattern. Moreover, its processing and marketing are specific to tea. Thus the Tea Industry stands apart and constitutes a self contained entity. This is reflected in the title given to this book, Tea: Cultivation to consumption, and its treatment of the subject. The book is logically planned - starting with the plant itself and finishing with the traditional'cuppa'. Every aspect of tea production is covered, inevitably some in greater detail than others. However, it gives an authentic and comprehensive picture of the tea industry. The text deals in detail with cultural practices and research, where desirable, on a regional basis. The technology of tea cultivation and processing has been developed within the industry, aided by applied research which was largely financed by the tea companies themselves. This contributed to a technically competent industry but tended to bypass the more academic and fundamental investigations which might bring future rewards. The sponsorship of research has now widened and the range and depth of tea research has increased accordingly. The editors and authors of this book have played their part in these recent developments which are well reported in the book.

Plant protoplasts have proved to be an excellent tool for in vitro manipu- lations, somatic hybridization, DNA uptake and genetic transformation, and for the induction of somaclonal variation. These studies reflect the far- reaching impact of protoplast alterations for agriculture and forest bio- technology. Taking these aspects into consideration, the series of books on Plant Protoplasts and Genetic Engineering provides a survey of the litera- ture, focusing on recent information and the state of the art in protoplast Plant Protoplasts manipulation and genetic transformation. This book, and Genetic Engineering VI, like the previous five volumes published in 1989,1993, and 1994, is unique in its approach. It comprises 27 chapters dealing with the regeneration of plants from protoplasts, and genetic transformation in various species of Arachis, Bupleurum, Capsella, Dendrobium, Dianthus, Diospyros, Fagopyrum, Festuca, Gentiana, Glycyrrhiza, Gossypium, Hemerocallis, Levisticum, Lonicera, Musa, Physallis, Platanus, Prunus, Saposhnikovia, Solanum, Spinacia, Trititrigia, Tulipa, and Vaccinium; including fruits such as apricot, banana, cranberry, pepino, peach, and plum. This book may be of special interest to advanced students, teachers, and research scientists in the field of plant tissue culture, molecular biology, genetic engineering, plant breeding, and general bio- technology. New Delhi, August 1995 Professor Y. P. S. BAJA] Series Editor Contents Section I Regeneration of Plants from Protoplasts 1. 1 Regeneration of Plants from Protop1asts of Arachis Species (Peanut) Z. LI, R. L. JARRET, and J. W. DEMSKI (With 2 Figures) 1 Introduction ...3 2 Isolation of Pro top lasts ...4 3 Culture of Protoplasts ...

27 chapters cover the distribution, economic importance, conventional propagation, micropropagation, tissue culture studies, and in vitro production of important medicinal and other pharmaceutical compounds in various species of Anchusa, Brucea, Catharanthus, Chrysanthemum, Coleus, Corydalis, Coreopsis, Emilia, Ginkgo, Gloriosa, Hypericum, Inonotus, Leucosceptrum, Lilium, Linum, Mosses, Nandina, Penstemon, Prunus, Pteridium, Quassia, Ribes, Senecio, Taraxacum, Thermopsis, Vanilla, and Vitiveria. Like the previous five volumes on medicinal and aromatic plants (Volumes 4, 7, 15, 21, and 24), this book contains a wealth of useful information for advanced students and researchers in the field of plant biotechnology and chemical engineering, pharmacy, botany and tissue culture.

The quality of human life has been maintained and enhanced for generations by the use of trees and their products. In recent years, ever rising human population growth has put tremendous pressure on trees and tree products; growing awareness of the potential of previously unexploited tree resources and environmental pollution have both accelerated development of new technologies for tree propagation, breeding and improvement. Biotechnology of trees may be the answer to solve the problems which cannot be solved by conventional breeding methods. The combination of biotechnology and conventional methods such as plant propagation and breeding may be a novel approach to improving and multiplying in large number the trees and woody plants. So far, plant tissue culture technology has largely been exploited in the propagation of ornamental plants, especially foliage house plants, by com mercial companies. Generally, tissue culture of woody plants has been recal citrant. However, limited success has been achieved in tissue culture of angiosperm and gymnosperm woody plants. A number of recent reports on somatic embryogenesis in woody plants such as Norway spruce (Picea abies), Loblolly pine (Pinus taeda), Sandalwood (Santalurn album), Citrus, Mango (Mangifera indica), etc., offer a ray of hope of: a) inexpensive clonal propa gation for large-scale production of plants or "emblings" or "somatic embryo plants," b) protoplast work, c) cryopreservation, d) genetic transformation, and e) artificial or manufactured seed production."

The research that has culminated in the pUblication being introduced . worldwide) save by one or two of this Manual was in the first place undertaken private conifer enthusiasts. My own efforts at 1 for a new edition of the book Manual of Cultivated recording data at Devizes made possible the Conifers by P. den Ouden and Dr B. K. Boom appearance in 1979 of a larger book: Manual of (both now deceased), published in 1965. Dwarf Conifers. That book was clearly in effect The claim in that book to have included every a partial up-dating of the den Ouden and Boom cultivar published since 1753 was not entirely book under revision, so the decision was made realised, and the stated objective, i. e. that the book to produce an entirely new work, with the present should serve as a basis for the international register title and with the following objectives. that was even at that date under consideration required a lot of space to be devoted to quite 1. To bring the taxonomy into line with current archaic information. practice. Each of the authors of the Manual of Cultivated 2. To extend the species descriptions and make them (by the use of side headings) more easy Conifers was well qualified for the task. P. den Ouden had been systematically collecting conifer to use. 3. To supply some form of 'keys'.

Science is essentially a descriptive and experimental device. It observes nature, constructs hypotheses, plans experiments and proposes theories. The theory is never contemplated as the 'final truth', but remains ever subject to modifications, changes and rejections. The science of allelopathy in a similar way has emerged, and exists on a similar footing; our endeavour should be to keep it fresh and innovative with addition of newer in formation and concepts with the rejection of older ideas and antiquated techniques. During the past few decades encouraging results have been obtained in various aspects of allelopathic researches. However, in addition to continuing efforts in all these directions, constant attempts are to be made to describe the mechanics of allelopathic activity in molecular terms and to discover ways and means to exploit it for the welfare of mankind. We feel that multidisciplinary efforts are the only tool to achieve this goal. It is the hope of the editors that this book will serve as a document which identifies an integrated approach, through which research both to understand and exploit allelopathy can be conducted. The present volume arose out of an attempt to bring together eminent scientists in allelopathy to describe their work, of a highly diverse nature, under one title."

Recent advances in gene technology, plant transformation, and the growing knowledge of DNA sequences of plants as well as of their most important parasites and symbionts offer many interesting prospects for the breeding of new crop varieties. This was not only recognized by the major seed companies, but also by the governments of developing countries and by worldwide foundations supporting their agriculture. The know-how gained by the seed companies on crops important for the agricultural industry in developed countries could easily be provided for free to the international and national organizations dedicated to development of crops important in the third world. Results obtained worldwide become easily available to everybody through the scientific literature. Likewise, agricultural research in, e.g., the USA or Europe profits from the natural plant gene pool available in the third world. All this definitely provides for the possibility of fast change, new prosperity and security of food supply in the whole world, if properly applied. The fast development also asks for ethical and sociopolitical considerations, whereby not doing the right can be as much a mistake as doing the wrong.

However, the transition from primitive to 'advanced' cultivars has had the effect of narrowing the genetic base. This has happened in two distinct ways: (1) selection for relative uniformity, resulting in 'pure' lines, multi lines, single or double hybrids, etc.; and (2) selection for closely defined objectives. Both of these processes have resulted in a marked reduction in genetic variation. At the same time, there has been a tendency to restrict the gene pool from which parental material has been drawn. This is a result of the high level of productivity achieved when breeding within a restricted but well-adapted gene pool, and of breeding methods which have made it possible to introduce specifically desired improvements, such as disease resistance and quality characteristics, into breeding stocks with a minimum of disturbance to genotypic structure. Developments in agriculture, such as intensive mechanization, the widespread application of fertilizers and the use of herbicides, fungicides and pesticides, have created a situation whereby a few, selected high yielding cultivars may be grown over large parts of the earth, so further contributing to a decline in crop genetic diversity. This process is under way in all countries, both developed and developing, and unfortunately in cludes some of the richest primary and secondary gene centres of several important food crops."

Mangrove ecosystems are being increasingly threatened by human activities. Their biotic productivity supplies food and other resources to the human populations that inhabit or make use of them. This volume highlights the results of a ten-year German / Brazilian research project, called MADAM, in one of the largest continuous mangrove areas of the world, located in northern Brazil. Based on the analysis of the ecosystem dynamics, management strategies for the conservation and sustainable use of mangroves are presented and discussed. Beyond the scientific results, this book also provides guidelines for the development of international cooperation projects.

This book presents the full text volume of the IUFRO (International Union of Forestry Research Organizations) Conference on Environmental Forest Science which was held in Kyoto, Japan on 19-23 October 1998. The conference was organized by IUFRO Division 8 Forest Environment and Kyoto University. Forests as environment for mankind as well as environment of forests per se are increasingly important in progress of current urbanization and regional development. The objective of this conference is to integrate many fields of related sciences to a new concept of environmental forest science, which will be developing and promising in the 21st Century. The book consists of sixty nine papers covering forests as environment from various aspects, forest ecosystems & biodiversity, forest hydrology, natural disasters (landslides and debris flows et al) in mountains and their reduction. The publication will be of value to foresters, ecologists, hydrologists, landslide engineers and policy makers related to environments.

Genetic Engineering, Volume 24 contains discussions of contemporary and relevant topics in genetics, including: -Gene silencing: principles and applications, -Integrins and the myocardium, -Plant virus gene vectors: biotechnology and applications in agriculture and medicine, -Novel approaches to controlling transcription, -Use of DNA polymorphisms in genetic mapping, -Application of FLP/FRT site-specific DNA recombination system in plants. This principles and methods approach to genetics and genetic engineering is essential reading for all academics, bench scientists, and industry professionals wishing to take advantage of the latest and greatest in this continuously emerging field.

Exploring a topic of vital and ongoing importance, "Traditional Forest Knowledge" examines the history, current status and trends in the development and application of traditional forest knowledge by local and indigenous communities worldwide. It considers the interplay between traditional beliefs and practices and formal forest science and interrogates the often uneasy relationship between these different knowledge systems.

The contents also highlight efforts to conserve and promote traditional forest management practices that balance the environmental, economic and social objectives of forest management. It places these efforts in the context of recent trends towards the devolution of forest management authority in many parts of the world.

The book includes regional chapters covering North America, South America, Africa, Europe, Asia and the Australia-Pacific region. As well as relating the general factors mentioned above to these specific areas, these chapters cover issues of special regional significance, such as the importance of traditional knowledge and practices for food security, economic development and cultural identity. Other chapters examine topics ranging from key policy issues to the significant programs of regional and international organisations, and from research ethics and best practices for scientific study of traditional knowledge to the adaptation of traditional forest knowledge to climate change and globalisation.

"

This book is a collection of chapters concerning the use of biomass for the sustainable production of energy and chemicals-an important goal that will help decrease the production of greenhouse gases to help mitigate global warming, provide energy security in the face of dwindling petroleum reserves, improve balance of payment problems and spur local economic development. Clearly there are ways to save energy that need to be encouraged more. These include more use of energy sources such as, among others, manure in anaerobic digesters, waste wood in forests as fuel or feedstock for cellulosic ethanol, and conservation reserve program (CRP) land crops that are presently unused in the US. The use of biofuels is not new; Rudolf Diesel used peanut oil as fuel in the ?rst engines he developed (Chap. 8), and ethanol was used in the early 1900s in the US as automobile fuel [Songstad et al. (2009) Historical perspective of biofuels: learning from the past to rediscover the future. In Vitro Cell Dev Biol Plant 45:189-192). Brazil now produces enough sugar cane ethanol to make up about 50% of its transportation fuel needs (Chap. 4). The next big thing will be cellulosic ethanol. At present, there is also the use of Miscanthus x giganteous as fuel for power plants in the UK (Chap. 2), bagasse (sugar cane waste) to power sugar cane mills (Chap. 4), and waste wood and sawdust to power sawmills (Chap. 7).

The International Society of Root Research sponsored the Symposium "Root Demographics and Their Efficiencies in Sustainable Agriculture, GrassLands and Forest Ecosystems," July 14-18, 1996, at the Madren Conference Center, Clemson University, Clemson, South Carolina, USA. The conference was a continuation of a series of international symposiums on root research held every three to four years. Symposiums have also been held twice in Vienna, Austria, and once in Uppsala, Sweden, and Almaty, Kazahkstan prior to the meeting at Clemson University. The sponsoring society has made a particular effort in these symposia to include root scientists from the former Soviet Union because of the importance of exchanging information on a worldwide basis. This symposium continued and promoted that effort by providing travel grants to several scientists from that region; however, funds for that purpose were limited. Therefore, in compiling these proceedings, a number of papers from scientists from the former Soviet Union and former Warsaw Pack countries have been included even though the scientists were not actually present for the SymPOSIum.

World of Unstable Mutations The book "Triplet Repeat Diseases of the Nervous System" overviews the lat est data on several disorders associated with unstable mutations. This field of re search is progressing extremely fast. The number of polymorphic mutations and diseases caused by these mutations is increasing almost every month. There is a strong interest to molecular bases of triplet repeat disorders. This is explained by growing necessity to develop molecular approaches for cure of these diseases. There fore, the authors of this book describe unstable mutations with the emphasis on molecular pathology. Broad discussion is presented on how polymorphic expan sions cause cell dysfunction. o The first chapter of the book focuses on the molecular pathological pro cesses that originate "unstable" mutations. The authors review several avail able models by which normal "stable" region of DNA become pathogenic and discuss possible mechanisms causing DNA instability. o The other chapters of the book describe inherited diseases associated with different types of unstable mutations. Based on the location of mutation in the disease gene, polymorphic expansions of the nervous system can be divided into two major groups. First group includes disorders with unstable expansions within the open reading frame of the gene such as Spinocer ebellar Ataxias caused by polyglutamine expansions. The second group in cludes diseases caused by expansions situated within the untranslated re gions of the gene.

In spite of all the efforts made in fire prevention and suppression, every year about 45 000 forest fires occur in Europe, burning ca. 0.5 million hectares of forests and other rural lands. The management of these burned forests has been given much less attention than fire prevention or fire suppression issues, but the post-fire management of burned areas raises strong concerns (economic and social impacts, soil erosion and water quality, biodiversity loss, forest restoration). Although there are a few publications which address post-fire management, the focus of these has been either on general approaches to restoration or specific topics such as preventing post-fire soil erosion. This book is about the post-fire management of fire-prone forest types in southern Europe. It provides the first comprehensive overview of the topic, ranging from stand-level to landscape-level management, and from emergency actions to long-term restoration approaches.