Molecular farming has been hailed as the "third wave" of genetically-modified organisms produced through biotechnology for the bio-based economy of the future. Unlike products of the first wave, such as herbicide resistant crop plants, which were perceived to benefit only the farmers who used them and the agrochemical companies who developed them, products of molecular farming are designed specifically for the benefit of the consumer. Such products could be purified from food or non-food organisms for a range of applications in industry, as well as animal and human health. Alternatively, the products of this technology could be consumed more directly in some edible format, such as milk, eggs, fruits or vegetables. There is a rapidly-growing interest Qn the part of the public as well as in the medical community in the role food plays in health, especially in the immunophysiological impact of food over and above the role of basic nutrition.

This publication contains the proceedings of a seminar held in Germany (Fed. Rep.) on May 4 -6, 1977, under the auspices of the Commission of the European Communities, as part of the EEC programme of co ordination of research on beef production. The programme was drawn up by a combined scientific working group on Genetics and Selection and on Nutrition and Management on behalf of the Beef Production Committee. The working group consisted of Professor Dr. Neimann S rensen (Denmark, Chairman), Dr. Brolund Larsen (Denmark), Mr. Boccard (France), Dr. H. de Boer (Netherlands), Priv.-Doz. Dr. B. Hoffmann (Germany, Fed. Rep.), Professor Dr. H.J. Langholz (Germany, Fed. Rep.), Dr. J.W.B. King (UK), Mr. R. Jarrige (France), Mr. B. Vissac (France), Professor Dr. A. Romita (Italy), Professor Dr. E.P. Cunningham (Ireland), Mr. P. L'Hermite (CEC) and Dr. J.C. Tayler (Scientific Adviser to CEC). The subject chosen for this seminar was drawn from the list of priorities in research objectives drawn up in 1973 by members of a committee (now the Standing Committee on Agricultural Research, ( PRA). One of the functions of this series of seminars was to summarise and update the information available on the selected subjects and to discuss future needs for research, so as to assist the Commission in evaluating the probable impact of research on agri cultural production within the Community."

Infertility is a problem for the couple and evaluation of the couple is preferable in a clinic where both males and females may be seen together. The contribution to care by the urologist and the gynaecologist each with an interest in infertility is different but complementary. My appreciation of this was sharpened between 1976 and 1985 during my association with the World Health Organization's Spe cial Programme of Research Development and Research Training in Human Reproduction at the meetings of the Steering Committee of its Task Force on Infertility. The deliberations of this group were aimed at developing a protocol for investigation of the infertile couple and it became apparent to me as a gynaecologist how important is the precise characterization of the male partner's role to the formulation of the management plan for the infertile couple. To improve the quality of our evaluation of the male partner our techni cal staff were trained in the semen methodology of the laboratory of Dr F Com haire of Ghent and we were joined by Dr CLR Barratt, male reproductive biologist. It seemed appropriate to share our enthusiasm for clinical andrology, so after discussion with Dr Comhaire and Professor T Glover, an eminent male reproductive biologist, then of Brisbane, who planned a sabbatical to his native was arranged for 1 and 2 May 1986. Professor Glover en Yorkshire, a meeting of the meeting."

The 5th International Symposium on Microbial Growth on C Compounds was held at the Biological 1 Center of the University of Groningen, Haren, The Netherlands, 11-16 August 1986. The meeting attracted well over 200 participants from 15 countries. This volume contains the formal presentations made at that time, which, because of the breadth of topics covered, were divided into seven sections of related papers. This meeting, under the chairmanship of Wim Harder, was both scientifically and socially very successful. This success cannot only be credited to the main presentations, but also to the well cared for 121 poster presentations, whereof the abstracts have been published separately. The series of Symposia will be continued in 1989, in the Federal Republic of Germany. We wish to acknowledge the invaluable help of Joke Daniels, Roberta Stroer-Schneider, Karin Uyldert, Hansje Bartelson and Josine van Verseveld-Stroer, who retyped the manuscripts resulting in a uniform presentation of these proceedings.

It is thirty years since the technique of high-yield preparation of isolated hepatocytes, by collagenase perfusion of the liver, was published. The original method described by Berry and Friend has undergone many minor modifications by other workers, and the two-step procedure introduced by Seglen in 1976 has become the most frequent way to prepare hepatocyte suspensions. An important development introduced by Bissell in 1973 was the use of the cells as the first step in monolayer culture. The availability of the isolated hepatocyte preparation as cells in suspension or culture has undoubtedly facilitated research on the liver. This was emphasised in our book, published (with Dr. Greg Barritt) in 1990, which described in detail methods of preparation and the properties of the isolated hepatocytes. It also discussed the usefulness of the preparation for the study of intermediary and xenobiotic metabolism, calcium ion transport, and the growth and differentiation of hepatocytes in culture. The book also touched briefly on a range of specialised techniques, including peri fusion, subcellular fractionation, transplantation, cryopreservation and measurement of intracellular pH. Although standard procedures for the manipulation of hepatocytes have not changed a great deal in ten years, they have undoubtedly been refined. This applies particularly to hepatocyte culture techniques, cryopreservation, and even to preparation of hepatocyte suspensions, where it is now feasible to use purified enzymes. There is also much more emphasis on the use and study of human hepatocytes, particularly in the field of pharmacology and therapeutics.

Acid-Base and Electrolyte Handbook for Veterinary Technicians provides an easy to understand yet comprehensive approach to acid-base and electrolyte balance. * Covers the physiology of fluids and their effect on acid-base and electrolyte balance * Offers detailed information on managing acid-base and electrolyte derangements in disease * Includes access to a companion website with case studies and multiple choice questions

Ensuring the well-being of animals is a primary concern for every veterinary practice. Split into easily accessible sections, part one of this book outlines the origin of animal behavior and how this has adapted to the domestic environment. Part two focuses on the role of the veterinary practice in preventing undesirable behavior, such as practice design, socialization classes and communication with owners. Part three gives practical advice for handling dangerous animals, discussing options such as euthanasia and working with referral veterinarians. Behavioral problems remain the number one cause of companion animal euthanasia; this book seeks to improve the situation for all involved.

Includes FREE CD-ROM histology atlas with 800+ images!

Please note some copies of the 6th edition CD are not Mac compatible. Blackwell Publishing has rectified this problem for future copies sold. If however you are unable to get your CD to work on your Mac and you are in North America please contact [email protected] or phone at 1-800-862-6657 and we will send you replacement CD. If you are outside the US please email [email protected] or phone at +44 1865 476532. We apologize for this error and any inconvenience caused.

The leading veterinary histology text returns with a fully updated sixth edition. Written in a concise, easy-to-understand style that's a pleasure to read, this new edition continues the student-friendly tradition originated by Dr. Dellmann, presenting the basics of histology including cytology and microscopic anatomy.

The Sixth Edition focuses on the most current knowledge of cell, tissue and organ structure and function. All information has been fully revised and updated by the authors, both experts in their fields. Written with first year veterinary students in mind, it is also an important resource for veterinarians, graduate students, and others who require information on animal tissue structure and function.

Highlights of the Sixth Edition include--
- An interactive CD-ROM histology atlas, including more than 800 high-quality color images, each accompanied by identifying labels and descriptive legends.
- New images and line drawings have been added to enhance the student's understanding of concepts.
- Two-page insert contains full-color histology images.
-Comprehensive listings of suggested readings at the end of each chapter encourage further study.
- The text is organized by body region, allowing the presentation to emphasize comparative species information so students can better appreciate how species differ in regard to key structures.

Whether you're a veterinary student or practicing professional, you should have this classic histology reference as part of your working library.

Clinical Guide to Fish Medicine Designed as a practical resource, Clinical Guide to Fish Medicine provides an evidence-based approach to the veterinary care of fish. This guide--written and edited by experts in the field--contains essential information on husbandry, diagnostics, and case management of bony and cartilaginous fish. This important resource: Provides clinically relevant information on topics such as anatomy, water quality, life-support systems, nutrition, behavioral training, clinical examination, clinical pathology, diagnostic imaging, necropsy techniques, anesthesia and analgesia, surgery, medical treatment, and transport Describes common presenting problems of fish, including possible differentials and practical approaches Reviews key information on non-infectious and infectious diseases of fish in a concise format that is easily accessible in a clinical setting Written for veterinarians, biologists, technicians, specialists, and students, Clinical Guide to Fish Medicine offers a comprehensive review of veterinary medicine of fish.

Man's attempts to learn about aspects of the human body and its functions by observation and study of animals are to be found throughout history, especially at times and in cultures where the human body was considered sacrosanct, even after death. This book describes the origins and later development, especially in the eighteenth and nineteenth centuries, of comparative medicine and its interrelationship with medicine and veterinary medicine and the efforts of its practitioners to understand and control outbreaks of infectious, epidemic diseases in humans and in domestic animals. In the nineteenth century their efforts and increasing professionalism led to the creation of specialised institutes devoted to the study of comparative medicine. Paradoxically the first such institute, the Brown Institution, opened in London in 1871, despite the fact that the study of this branch of medicine in Britain had always lagged behind that in France and Germany. The book discusses the rise and fall of this centre and describes how it was soon overtaken in importance by the great institutes in Paris and Berlin and then, from the turn of the century, by American institutes, funded by private fortunes. This book sheds much new light on the medical and veterinary history of this period and will provide a new perspective on the history of bacteriology.

A few months of married bliss, a lovers' nest in Darrowby and the wonders of home cooking are rudely interrupted for James Herriot by the Second World War. From the author whose books inspired the BBC series All Creatures Great and Small, Vets Might Fly, James Herriot's fifth volume of memoirs relocates him to a training camp somewhere in England. And in between square pounding and digging for victory, he dreams of the people and livestock he left behind him.

Performing the Small Animal Physical Examination offers an easy-to-follow guide to successfully executing a thorough physical exam in cats and dogs, with nearly 1,000 clinical photographs depicting step-by-step details. * Provides comprehensive, practical information on the physical examination in small animal patients * Presents nearly 1,000 color photographs with step-by-step details of the procedures and principles * Offers advice on preparing the examination room, useful tips, and concrete guidance for examining each body system * Outlines a systematic, in-depth approach to the initial examination in dogs and cats * Supports new and experienced veterinarians and veterinary technicians alike in performing a thorough basic exam

The diversity of species in which drugs are used for clinical purposes and the emphasis on various classes of drugs make veterinary pharmacology a complex subject. Anatomical and physiological features influence the pharmacokinetic behaviour of a drug in a particular animal and the dosage required. This book is concerned with the basis of species differences, the selection of pharmacokinetic parameters and the interpretation of values obtained. There are chapters on bioavailability and its application to veterinary dosage forms, changes in drug disposition and interspecies scaling, clinical selectivity and stereoisomerism, drug permeation, antimicrobial disposition and specifics related to neonatal animals.

The author has gathered all this information together in one place so allowing the reader to make better selection of drug preparations for animal dosages to effectively treat animal diseases.

The book will prove valuable to clinical researchers in the areas of pharmacology, anaesthesia, microbial infections and, internal medicine as well as postgraduate students of these disciplines.

The Author

J Desmond Baggot (MVM, PhD, DSc, FRCVS, DipECVPT) is currently Visiting Professor of Veterinary Pharmacology at the School of Veterinary Medicine, St George's University, Grenada, West Indies. He was a contributing author and co-author of "Antimicrobial Therapy in Veterinary Medicine, 3rd Edition "(2000) and "Development and Formulation of Veterinary Dosage Forms, 2nd Edition "(1998) and the author of "Principles of Drug Disposition in Domestic Animals" (1977). Elucidations of the processes that underline species variation in the disposition of drugs and interpretation of the influence of disease states on drug disposition have been the focus of his research endeavours. He was a member of the Editorial Board of the "Journal of Veterinary Pharmacology and Therapeutics "from 1978 to 1996. He is a former Professor of Clinical Pharmacology at the School of Veterinary Medicine, University of California, Davis and Preclinical Veterinary Studies at the University of Zimbabwe, Harare.

Beginning with their sources, including manure and animal feed, and detailing their development, spread and transmission to humans, Zoonotic Pathogens in the Food Chain gives an insightful introduction to and epidemiological overview of the problems raised by zoonotic pathogens. The authors specifically examine the attributes of microorganisms that allow potential contamination of food sources and the factors in modern animal production processes that contribute to the risk of infection. Chapters discuss in detail pathogens that have recently emerged as important sources of infection, investigating in depth the implications of avian flu, swine flu, bovine spongiform encephalopathies and Johne's disease for human consumers, and considering where potential mitigation strategies should be focused. With a focus on new trends in animal production, such as organic livestock farming and raw milk consumption, this text provides an interesting and up-to-date reference for researchers, academics and those with an interest in pathology working in the livestock industry.

The Hair-Raising Adventures of an Irish Vet. Whether castrating horses in Dublin's inner city or dehorning cattle in the wilds of Wicklow, rescuing mangled cats from mongrels or tending to stoned guard dogs, vet Gillian Hick's sense of humour never deserts her in this engaging account of the challenging situations she encounters in the course of her work as a newly qualified veterinary surgeon. Not only does she have to deal with the animals and their ailments, but she also has to contend with the perils of matchmaking mothers and macho farmers -- not to mention the guys who want to know 'where is the real vet?'

This book presents current research in the study of livestock, with a particular focus on livestock rearing, farming practices and associated diseases. Topics discussed include a new generation of dietary supplements with microelements for livestock; pastoralism and the changing climate in northern Kenya; Bangladesh poultry sector; parasitic diseases in livestock under different farming practices; salmonella and salmonellosis in animals and humans; bovine tuberculosis at the human-animal interface and anthelmintic resistance.

"Veterinary Euthanasia Techniques: A Practical Guide" provides detailed guidance on euthanasia procedures in a wide variety of species, including dogs, cats, exotics, horses, and production animals. Based on the current AVMA guidelines, the book offers step-by-step descriptions of the recommended methods of euthanasia, giving all the information needed to perform these techniques with confidence. "Veterinary Euthanasia Techniques" helps practitioners, students, and technicians expand their knowledge base and provide competent, compassionate euthanasia services.

Including information on client considerations, equipment, positioning, sedation, and aftercare, the focus of the book is on providing detailed procedures for correctly performing euthanasia. "Veterinary Euthanasia Techniques" presents complete information on euthanasia, offering specific advice to improve skills and aid in decision making.

There are many ongoing debates within and about the subject of animal welfare. This book distils some of the major themes of current debate into one volume, edited by internationally known names in the field of animal welfare. Each chapter is written by one or more leading experts who discuss, in an even-handed way, a provocative topic that will be of interest to anyone concerned with animal welfare. Issues covered include tail docking, farm animal production, neutering of feral cats and the need to conserve habitats of native wild animals in the face of threats from non-native species. Chapters address the different values and priorities involved in dealing with these issues, including scientific and more explicit ethical approaches. Each chapter ends with questions for discussion that may help readers to engage with these dilemmas.

Tackling One Health from a multi-disciplinary perspective, this book offers in-depth insight into how our health and the health of every living creature and our ecosystem are all inextricably connected. Presents critical population health topics, written by an international group of experts Addresses the technical aspects of the subject Offers potential policy solutions to help mitigate current threats and prevent additional threats from occurring

Taking a disease-based approach, Fish Viruses and Bacteria: Pathobiology and Protection focuses on the pathobiology of and protective strategies against the most common, major microbial pathogens of economically important marine and freshwater fish. The book covers well-studied, notifiable piscine viruses and bacteria, including new and emerging diseases which can become huge threats to local fish populations in new geographical regions if transported there via infected fish or eggs. A concise but thorough reference work, this book: - Covers key viral and bacterial diseases of notable fish species; - Reviews major well-established piscine pathogens as well as new, emerging and notifiable diseases; and - Contains the most up-to-date research contributed by a team of over fifty world experts. An invaluable bench book for fish health consultants, veterinarians and all those wanting instant access to information, this book is also a useful textbook for students specializing in fish health and research scientists initiating fish disease research programmes.

A heartwarming love letter to the places, people and creatures of Yorkshire by the county's beloved vet, Channel 5's Peter Wright. The Yorkshire Vet takes us on an enchanting journey through the hidden gems of the most beautiful county in the world, sharing charming tales of his life in Thirsk as well as fascinating nuggets of local history. Packed with engaging tales of the animals, people and places around him, Peter Wright looks back on the bygone ways of his childhood, while also exploring the fusion of tradition and modernity that characterises the Yorkshire countryside today. Peter's passion for nature shines through on every page, as he explains why our environment is so important - and what we can do to protect it for future generations.

The newly revised Second Edition of Bovine Reproduction delivers a comprehensive overview of all major issues in bovine reproduction. Written by leading experts in the subject, the book is an indispensable reference for any veterinarian dealing with bovine fertility.

Bovine Reproduction is divided into sections on the bull, the cow, the neonate, and assisted reproduction techniques. New chapters cover new gene manipulation technologies, managing problem donors, lameness, and more. Outdated and redundant information from the First Edition has been removed and replaced by coverage of new diseases, technologies, procedures, techniques, and approaches to fertility problems.

A new companion website provides images and tables from the book in PowerPoint format. In addition to more than 675 full-color images, readers will also benefit from:

• A thorough discussion of the anatomy and physiology of the bull, including the endocrine and exocrine function of bovine testes and the thermoregulation of the testes
• An exploration of breeding and health management of bulls, including the evaluation of breeding soundness and ultrasound examination of the reproductive tract
• An examination of the anatomy, physiology, and the breeding and health management of cows, including fetal programming, the reproductive tract microbiome, and a section on obstetrics and reproductive surgery
• A review of the management of both critical care of the neonate and effective colostrum assessment and provision
• An introduction to assisted and advanced reproductive technologies

A practical and comprehensive reference, Bovine Reproduction is a must-have purchase for bovine practitioners, theriogenologists, animal scientists, veterinary students, and residents with an interest in cattle.