Im Vergleich zum Humansport ist der tierische Athlet im Reitsport als gleichberechtigter Sportpartner den kunstlichen Leistungssteigerungen ohne Mitspracherecht ausgesetzt. In Anbetracht der erheblichen Zunahme von Dopingfallen im nationalen und internationalen Reitsport mussten sich die Pferdesportverbande unter Berucksichtigung des World-Anti-Doping Codes materiell- und verfahrensrechtlich neu positionieren. Ziel dieser Arbeit ist es zu beleuchten, inwieweit die Regeln des WADA- und NADA-Codes, die in erster Linie fur den Humansport konzipiert wurden und fur den Pferdeport nur rudimentare Regelungen enthalten, durch den nationalen und internationalen Pferdesportverband unter Beachtung des jeweils geltenden Rechts umsetzbar sind und inwieweit langen sowie kostenintensiven Dopingverfahren vor den staatlichen Gerichten zugunsten der Sportgerichtsbarkeit ein Ende gesetzt werden kann. Vor diesem Hintergrund gilt es einen internationalen Entscheidungseinklang in der sportrechtlichen Anti-Doping Rechtsprechung mithilfe der Sportschiedsgerichtsbarkeit weiter zu fordern und zu foerdern.

Despite recent progress in many areas of treatment and control, cancer remains a frightening threat to everyone. While scientists have known for decades that the majority of human cancers are caused by environmental agents such as radiation and the chemicals in cigarette smoke, not everyone who smokes gets lung cancer. Furthermore, many people who assiduously avoid all possible risk from smoking, diet, and pollution still succumb to some form of cancer later in life. Does this mean that there is an element of blind chance in the underlying mechanisms of human carcinogenesis? To what extent do genetic influences play a role in determining the cancer risk of individuals? A number of `cancer families', in which several closely related individuals have suffered from various specific forms of cancer, have been studied by genetic epidemiologists. However, for the majority of cancer cases, little or no discernible genetic influence or family history is found. Recent research has discovered that for many of these `sporadic' (non-familial) cancer cases, defects or aberrations in certain metabolic genes not previously associated with genetic cancer risk may contribute to either causing the disease or at least increasing the chances of developing cancer. It is therefore possible that much of what has previously passed for `bad luck' may turn out to be a new type of `bad genes'. Genetic Susceptibility to Cancer explains that this new idea of `bad genes' may contain an unexpected positive side. The carcinogenic effects of these metabolic genes, unlike those of the oncogenes and tumor suppressor genes that are responsible for the inherited cancer syndromes, can potentially be overcome or nullified. Genetic Susceptibility to Cancer will provide a valuable reference for health professionals, researchers, clinicians and biomedical scientists who are interested in the current thinking in this critically important area of cancer management.

Our purpose is to provide understanding for appropriate use of metals in a technical society. Knowledge of metal toxicity is needed for the preven tion, prediction, diagnosis, and therapy of adverse reactions from excess metals in mammals. Metal Toxicity in Mammals is presented in two volumes. Volume 1, Physiologic and Chemical Basis for Metal Toxic ity, provides the basis for understanding the toxic actions of metals recorded in Volume 2, Chemical Toxicity of Metals and Metalloids. The details and bases for many concepts summarized in Volume I are given, with appropriate references, in Volume 2. Thus, references for specific items in Volume 2 are not generally given in Volume 1. The authors reviewed the known toxicity of several heavy metals in anticipation of their use as multinutrient markers for NASA. As more and more metals were considered, the need for a complete review became obvious. This treatise supplants onerous searches of metal-toxicity litera ture up to 1975 and reviews the toxicity of all the metals of the periodic table on the basis of available relevant data. Books on pharmacological, nutritional, medical, veterinary, or industrial toxicity contain information about selected metals. More complete data about metals of public concern, such as mercury, lead, and cadmium, may be found in numerous books and reviews. The reader should refer to general texts and basic reference works, when specific references are not given, for general information."

In the past half century, filamentous fungi have grown in commercial importance not only in the food industry but also as sources of pharmaceutical agents for the treatment of infectious and metabolic diseases and of specialty proteins and enzymes used to process foods, fortify detergents, and perform biotransformations. The commercial impact of molds is also measured on a negative scale since some of these organisms are significant as pathogens of crop plants, agents of food spoilage, and sources of toxic and carcinogenic compounds. Recent advances in the molecular genetics of filamentous fungi are finding increased application in the pharmaceutical, agricultural, and enzyme industries, and this trend promises to continue as the genomics of fungi is explored and new techniques to speed genetic manipulation become available. This volume focuses on the filamentous fungi and highlights the advances of the past decade, both in methodology and in the understanding of genomic organization and regulation of gene and pathway expression.

The last half-century has shown a dramatic increase in the standard of living of millions of people in Europe, North America and many parts of the Third World. This has, in many ways been brought about by scientific and technical developments which were initiated in the 1940s and 1950s. Promises were then made that nuclear energy would provide electricity so cheap that it would not need metering, pesticides would end malnutrition throughout the world and plastics and other synthetic chemicals would revolutionise our manufacturing industry and our way of life. Whilst some of these promises have been fulfilled, the problems of long-term health risks to humans and wildlife arising from the use, production and disposal of these products were either unknown or deliberately understated. Nuclear power is rendered economically unviable when the real cost of decommissioning and storage of waste for several millenia is included, and the effects on health of both humans and wildlife of early pest eradication programmes with organochlorine pesticides were well documented in Rachel Carson's "Silent Spring." Evidence of the effects of aerosols and refrigerants on depletion of the ozone layer has led to restriction on the use of CFCs, and there is now increasing evidence of climate change resulting from our profligate use of fossil fuels.

Concern is often expressed that our environment may include an increasingly large variety of mutagens, but the extent of the potential hazard they pose has yet to be fully evaluated. A variety of empirical procedures has been devised with which to estimate the mutagenic potency of suspect agents, and the relative merits of different tests are currently under debate. Although such tests are of great value, and are indeed indispensable, they are not, nevertheless, sufficient. In the long term, accurate estimation of hazard will also require a better understanding of the various mechanisms of mutagenesis, and in many instances these remain remarkably elusive. Our knowledge and appreciation of the problem has increased substantially over the last few years, but the precise way in which many mutagens cause mutations is not yet known. The aims of this conference were therefore two-fold. The first was to survey present information about mutagenic mechanisms, drawing together data from work with various experimental approaches and organisms, in order to discern the principles governing the action of different mutagens. The second was to examine the implications of such principles for the execution and evaluation of test procedures, and critically assess the research areas that need further attention in order to improve the interpretation of test results. Chris Lawrence v ACKNOWLEDGEMENT We gratefully acknowledge the support provided for this Conference by the U., S. Department of Energy, The Foundation for Microbiology, Exxon Corporation and the University of Rochester

With the growing incidence of fragility fractures in Europe and North America over the last three decades, bone loss and osteoporosis have become active areas of research in skeletal biology. Bone loss is associated with aging in both sexes and is accelerated in women with the onset of menopause. However, bone loss is related to a suite of complex and often synergistically related factors including genetics, pathology, nutrition, mechani cal usage, and lifestyle. It is not surprising that its incidence and severity vary among populations. There has been increasing interest to investigate bone loss and osteoporosis from an anthropological perspective that utilizes a biocultural approach. Biocultural approaches recognize the inter-relationship between biological, cultural, and environmental variables. Anthropological studies also highlight the value of evolutionary and population approaches to the study of bone loss. These approaches are particularly suited to elucidate the multifactorial etiology of bone loss. The idea for this volume came out of a symposium organized by the editors at the 70th annual meeting of The American Association of Physical Anthropologists in Kansas City, Missouri. Many of the symposium participants, along with several additional leading scientists involved in bone and osteoporosis research, are brought together in this volume. Each chapter focuses on a different aspect of bone loss and fragility with a fresh and stimulating perspective.

4* Doody's Review! Ideal for veterinary students, residents and clinicians, the fourth edition of this bestselling textbook has been fully updated in line with developments in research and teaching. The logical chapter progression reflects the stages in a clinical case work-up and how epidemiological concepts and methods contribute. This new edition provides guidelines for improving patient and population health outcomes, and detecting emerging diseases through systematic evaluation of patient encounters and electronic medical records incorporates new methodologies and concepts drawn from the recent veterinary practice literature updates chapter content including expanded coverage of risk, statistical and economic analyses, and surveillance for emerging diseases more than 60 examples of clinical research drawn from the international veterinary practice literature presented as structured abstracts; follow-up questions invite the reader to participate in the analysis of results online links to full text versions of more than half of structured abstracts and more than 40% of the book's 174 literature citations updates the listing and review of public and private online resources, including guidelines for online literature searching and critical evaluation of clinical reports. Today's veterinary curricula places greater emphasis on experiential/problem-based learning versus discipline-oriented instruction. This fourth edition is ideally suited to introduce epidemiologic concepts and methodologies to veterinary students in the context of the patient encounter, and should be of use at any point in the veterinary curriculum.

No one is better placed to write the biography of Alf Wight, alias James Herriot, than the son who worked alongside him in the veterinary practice during the time that James Herriot became a best-selling author. In this warm and often poignant memoir Jim Wight writes of a man who, despite his huge success as a writer, remained unchanged by wealth and fame; an essentially private person whose family had to share him with his millions of fans throughout the world. Alf Wight was born in Sunderland, but moved a few weeks later to Glasgow; here he had a happy rough-and-tumble childhood. After training at the Glasgow Veterinary College he accepted a job in the Yorkshire town of Thirsk (aka Darrowby) where he remained in practice for over fifty years. The story of the young vet's journey to Thirsk to take up the post of assistant vet to Donald Sinclair (Siegfried Farnon) is one that is well-known through James Herriot's celebrated books, as well as two films and the All Creatures Great and Small television series. Alf Wight was respected and trusted by everyone whose animals he tended and, as James Herriot, loved by a huge and loyal readership the world over.

Scientists are coming under increasing pressure from activist groups to stop animal experimentation, branded as cruel and unnecessary for improving human health. This attitude, however, stems from an unrealistic evaluation of the situation and distorted information about present scientific knowledge. There is no question that most medical progress - perhaps all, in fac- has been attained through knowledge derived initially from experiments in various animal species. There is practically no way of replacing animals in these investigations and so-called 'alternative methods' are in reality merely complementary. Tissue cultures, cell, microorganisms, enzymes, membranes, mathematical models - all are useful for preliminary screening tests and for testing hypotheses, but the complexity of a living organism is such that in vivo studies are essential before any test can responsibly be made in man. This book presents the proceedings of an international symposium organized in Strasbourg (October 24-25, 1988), with the aim of assessing present-day requirements as regards animal experimentation in research related to major medical and toxicological problems still awaiting solutions.

Infertility is a problem for the couple and evaluation of the couple is preferable in a clinic where both males and females may be seen together. The contribution to care by the urologist and the gynaecologist each with an interest in infertility is different but complementary. My appreciation of this was sharpened between 1976 and 1985 during my association with the World Health Organization's Spe cial Programme of Research Development and Research Training in Human Reproduction at the meetings of the Steering Committee of its Task Force on Infertility. The deliberations of this group were aimed at developing a protocol for investigation of the infertile couple and it became apparent to me as a gynaecologist how important is the precise characterization of the male partner's role to the formulation of the management plan for the infertile couple. To improve the quality of our evaluation of the male partner our techni cal staff were trained in the semen methodology of the laboratory of Dr F Com haire of Ghent and we were joined by Dr CLR Barratt, male reproductive biologist. It seemed appropriate to share our enthusiasm for clinical andrology, so after discussion with Dr Comhaire and Professor T Glover, an eminent male reproductive biologist, then of Brisbane, who planned a sabbatical to his native was arranged for 1 and 2 May 1986. Professor Glover en Yorkshire, a meeting of the meeting."

The 5th International Symposium on Microbial Growth on C Compounds was held at the Biological 1 Center of the University of Groningen, Haren, The Netherlands, 11-16 August 1986. The meeting attracted well over 200 participants from 15 countries. This volume contains the formal presentations made at that time, which, because of the breadth of topics covered, were divided into seven sections of related papers. This meeting, under the chairmanship of Wim Harder, was both scientifically and socially very successful. This success cannot only be credited to the main presentations, but also to the well cared for 121 poster presentations, whereof the abstracts have been published separately. The series of Symposia will be continued in 1989, in the Federal Republic of Germany. We wish to acknowledge the invaluable help of Joke Daniels, Roberta Stroer-Schneider, Karin Uyldert, Hansje Bartelson and Josine van Verseveld-Stroer, who retyped the manuscripts resulting in a uniform presentation of these proceedings.

Acid-Base and Electrolyte Handbook for Veterinary Technicians provides an easy to understand yet comprehensive approach to acid-base and electrolyte balance. * Covers the physiology of fluids and their effect on acid-base and electrolyte balance * Offers detailed information on managing acid-base and electrolyte derangements in disease * Includes access to a companion website with case studies and multiple choice questions

It is thirty years since the technique of high-yield preparation of isolated hepatocytes, by collagenase perfusion of the liver, was published. The original method described by Berry and Friend has undergone many minor modifications by other workers, and the two-step procedure introduced by Seglen in 1976 has become the most frequent way to prepare hepatocyte suspensions. An important development introduced by Bissell in 1973 was the use of the cells as the first step in monolayer culture. The availability of the isolated hepatocyte preparation as cells in suspension or culture has undoubtedly facilitated research on the liver. This was emphasised in our book, published (with Dr. Greg Barritt) in 1990, which described in detail methods of preparation and the properties of the isolated hepatocytes. It also discussed the usefulness of the preparation for the study of intermediary and xenobiotic metabolism, calcium ion transport, and the growth and differentiation of hepatocytes in culture. The book also touched briefly on a range of specialised techniques, including peri fusion, subcellular fractionation, transplantation, cryopreservation and measurement of intracellular pH. Although standard procedures for the manipulation of hepatocytes have not changed a great deal in ten years, they have undoubtedly been refined. This applies particularly to hepatocyte culture techniques, cryopreservation, and even to preparation of hepatocyte suspensions, where it is now feasible to use purified enzymes. There is also much more emphasis on the use and study of human hepatocytes, particularly in the field of pharmacology and therapeutics.

Molecular farming has been hailed as the "third wave" of genetically-modified organisms produced through biotechnology for the bio-based economy of the future. Unlike products of the first wave, such as herbicide resistant crop plants, which were perceived to benefit only the farmers who used them and the agrochemical companies who developed them, products of molecular farming are designed specifically for the benefit of the consumer. Such products could be purified from food or non-food organisms for a range of applications in industry, as well as animal and human health. Alternatively, the products of this technology could be consumed more directly in some edible format, such as milk, eggs, fruits or vegetables. There is a rapidly-growing interest Qn the part of the public as well as in the medical community in the role food plays in health, especially in the immunophysiological impact of food over and above the role of basic nutrition.

This volume provides broad insights to the most recent discoveries in telomere biology, with current applications in tumor diagnostics and future potentials in therapy. Special features of diverse organisms are presented, with ciliates, the "telomerase discoverer organisms"; yeasts, the "molecular genetisists' toy for eukaryotes"; including plants and insects as well. 28 chapters were written by a group of leading research scientists, working in the telomere/telomerase fields today. This book will be a core reference for any physician, scientist or "educated reader" with an interest in the exciting developments in this research field.

This volume brings together current research on the behavior, ecology, reproduction, and life history of baboons of the genus Papio, shedding light on what makes baboons successful. The book focuses on issues such as infanticide, mating strategies and investment, hybridization and genetics. The findings have broad applications to understanding the evolution of complex life history adaptations in other primates, and of humans in particular.

The Welfare of Animals is an exciting book that will stimulate and provoke its readers. It describes many problems faced by animals - those we use for food, for pleasure or in research, and those simply but harshly affected by shrinking habitats in the face of the ever-growing human population. And yet it is not a depressing read. It focuses not only on the difficulties that animals face, but on their capacity for free-choice, for joy and excitement, and on the possible ways in which the planet can be shared between species if only we take the time and trouble to think more carefully about the impact of our actions. Clive Phillips moved from the United Kingdom to take up a Foundation Chair in Animal Welfare at the University of Queensland, becoming Australia's first Professor of Animal Welfare in 2003. This cultural leap, combined with his travels in countries like Malaysia and Borneo, permits him the unique and broad perspective that forms the backbone of this book. Eschewing the normal territory patrolled by the animal scientist (explaining the physiological basis of the stress response or causation of abnormal behaviour), Clive ventures into jungles and deserts, city centres and tribal homelands, and presents a book that remarkably and successfully combines travel-diary, nature notes, social and cultural history.

Gary Wobeser's successful book from 1994 has been completely updated and enlarged in a new second edition. An in-depth overview of the available techniques for the investigation and management of disease in free-ranging animals is provided. The subjects are illustrated with examples drawn from around the world, with emphasis on the special requirements involved in working with wild animals. The book draws on the author 's training as a wildlife biologist.

Lesson number one: When taking a cow's temperature the old-fashioned way, never let go of the thermometer . . . Now firmly ensconced in the sleepy Yorkshire village of Darrowby, recently qualified vet James Herriot has acclimatized to life with his unpredictable colleagues, brothers Siegfried and Tristan Farnon. But veterinary practice in the 1930s was never going to be easy, and there are challenges on the horizon, from persuading his clients to let him use his 'modern' equipment, to becoming an uncle (to a pig called Nugent). Throw in his first encounters with Helen, the beautiful daughter of a local farmer, and this year looks to be as eventful as the last... From the author whose books inspired the BBC series All Creatures Great and Small, It Shouldn't Happen to a Vet is the second volume of James Herriot's classic memoirs; a book for all those who find laughter and joy in animals, and who know and understand the magic and beauty of Britain's wild places.

Man's attempts to learn about aspects of the human body and its functions by observation and study of animals are to be found throughout history, especially at times and in cultures where the human body was considered sacrosanct, even after death. This book describes the origins and later development, especially in the eighteenth and nineteenth centuries, of comparative medicine and its interrelationship with medicine and veterinary medicine and the efforts of its practitioners to understand and control outbreaks of infectious, epidemic diseases in humans and in domestic animals. In the nineteenth century their efforts and increasing professionalism led to the creation of specialised institutes devoted to the study of comparative medicine. Paradoxically the first such institute, the Brown Institution, opened in London in 1871, despite the fact that the study of this branch of medicine in Britain had always lagged behind that in France and Germany. The book discusses the rise and fall of this centre and describes how it was soon overtaken in importance by the great institutes in Paris and Berlin and then, from the turn of the century, by American institutes, funded by private fortunes. This book sheds much new light on the medical and veterinary history of this period and will provide a new perspective on the history of bacteriology.

Predicting 25 years out is no easy task - long term assessments have variable criteria such as sustainability, strategic relevance, and financial performance. In "Veterinary Medicine and Practice 25 Years in the Future and the Economic Steps to Get There," Tom Catanzaro and Terry Hall condense facts from recent studies, identify the social and technological long-term trends to watch, and supply an economic roadmap that will help veterinary professionals steer their practices through the next quarter of a century.

The insightful book
summarizes emerging trends in veterinary healthcare delivery.
offers financial planning priorities for veterinarians by career stage (priorities for new graduates, new buyers of a practice, practice owners nearing retirement, etc.).
stresses fundamental financial principles and life-balance needs.
outlines the steps and strategies veterinarians should follow to ensure financial well-being.

Most of the future increase in livestock production is expected to occur in the tropical and subtropical regions of the world. Cattle are the most numerous of the ruminant species in the tropics and provide the largest quantity of animal food products. More than one-third of the world's cattle are found in the tropics. Disease is the major factor which prohibits full utilization of these regions for cattle production. Various infectious and transmissible viral, rick ettsial, bacterial, and particularly protozoan and helminthic diseases, are widespread in the tropics and exert a heavy toll on the existing cattle industry there. This uncontrolled disease situation also discourages investment in cattle industries by private and government sectors. In Africa alone, it is estimated that 125 million head of cattle could be accommodated in the tropical rainbelt if the disease and other animal husbandry factors could be resolved. The potential of efficient cattle production under more favorable conditions prompted various international agencies to establish a multi million dollar International Laboratory for Research in Animal Diseases (ILRAD) in Nairobi, Kenya, Africa. In South America, principal sites for raising cattle are shifting to the savannah lands because the more fertile soils are being used for crop produc tion, however, in the savannahs also, disease remains the most powerful deterrent in implementing the cattle industry."