When a biological drug patent expires, alternative biosimilar products are developed. The development of biosimilar products is complicated and involves numerous considerations and steps. The assessment of biosimilarity and interchangeability is also complicated and difficult. Biosimilar Drug Product Development presents current issues for the development of biosimilars and gives detailed reviews of its various stages and contributing factors as well as relevant regulatory pathways and pre- and post-approval issues.

The relationship between trade policy and economic performance is one of the oldest controversies in economic development. In recent years, there has been a revival of interest in the debate on the implications of trade reforms for productivity growth and domestic pricing behaviour due in part to the current phase of wide-spread trade liberalisation in developing countries and in part to developments in economic theory, notably endogenous growth theories and theories of imperfect competition. Also, there has been considerable interest in whether trade reforms can lead to higher wage inequality and regional inequality in developing countries. Both in academic and policy arenas the interest in international trade as a powerful positive force for reducing poverty in low-income countries has increased. In this book, the author examines the implications of trade reforms with specific reference to the Indian manufacturing sector. In particular, it explores the evolution of regional and wage inequality, employment, productivity and prices from the import substitution phase of the 1970s to the period of radical reforms of the 1990s. The strength of the book is the careful and systematic examination of the various aspects of the trade-development nexus using rigorous empirical methods and a detailed data-set of Indian industries from 1975 to 2000. Economists in general and South Asian scholars in particular will find this thorough study interesting and useful.

This work examines the roles that American businesses and photojournalists played in the early overseas marketing of the Japanese??????built Nikon camera and its Nikkor optics between 1946 and 1951. Particular attention is paid to the San Francisco??????based Overseas Finance and Trading Company, which was the major U.S. importer of Nikon products between 1949 and 1953. The work also details the roles of Overseas Finance leaders Hans Liholm and Adolph Gasser in providing marketing and technical guidance to Nikon in the company's formative years.

This book examines the political economy of attempts to restructure the Donbass, one of the Soviet Union's most important 'old economy' 'rustbelt' industrial regions. It shows how local interest groups have successfully frustrated the central government's and the World Bank's proposed market-oriented restructuring, and how a manufacturing-based regional economy is surviving, partially, with restructuring postponed.

Tavistock Press was established as a co-operative venture between the Tavistock Institute and Routledge & Kegan Paul (RKP) in the 1950s to produce a series of major contributions across the social sciences. This volume is part of a 2001 reissue of a selection of those important works which have since gone out of print, or are difficult to locate. Published by Routledge, 112 volumes in total are being brought together under the name The International Behavioural and Social Sciences Library: Classics from the Tavistock Press. Reproduced here in facsimile, this volume was originally published in 1951 and is available individually. The collection is also available in a number of themed mini-sets of between 5 and 13 volumes, or as a complete collection.

Whether used as predictors or indicators of stock prices, financial risk, merger candidates, or bond yields, financial ratios have been, and continue to be, a popular tool for analyzing a firm and its performance. Practitioners and academics who employ financial ratios often compare and contrast across several industries, but such evaluations assume that the ratios of one industry measure the same underlying concepts as the ratios of another. This book provides evidence on the comparability of financial ratios across several industries, assessing the similarity or dissimilarity of ratios among industry taxonomies, or groups of ratios.

Extending previous studies that focused primarily on manufacturing firms, this work surveys a wide variety of both manufacturing and retail corporations, and determines the classification patterns of their respective financial ratios. The taxonomies of thirty two ratios, in seven representative industries, are examined for the ten-year period from 1978 through 1987. Two introductory chapters detail the nature of the research, the data utilized, variables employed, and statistical methodologies, as well as providing a brief summary of the results. A third chapter furnishes results for the entire economy by factors of return, cash flow, cash position, inventory, sales, liquidity, and debt; while seven separate chapters describe the study's conclusions for each of the primary industries: automobile and aerospace; chemical, rubber, and oil; electronics; food; retail; steel; and textile. The work concludes with a summary of the study and its conclusions, and an examination of the limitations of this type of research and possibilities for its extension. This book will be a valuable practical resource for accounting and finance professionals, as well as an important reference for courses in finance, accounting, and management. Public, academic, and business libraries will also find it a useful addition to their collections.

Why have Africans not gained a more dominant position in urban manufacturing in Kenya? This question is explored through an analysis of the institutions, both formal and informal, that have affected patterns of capital accumulation in Kenya by the African and Asian (Indian) communities. Using a new institutional economics approach, this book explores the history of economic activity through the pre-colonial, colonial and post-colonial periods, including the transformative period of British rule. During the colonial period, Asians were brought in to build the railways and subsequently focused on urban-based activities. Africans, meanwhile, found it difficult to move out of agriculture. Thus, the ethnic-sectoral division of activities was entrenched by the formal laws and powers of the British. Following independence, the network and financial capital that Asians had built up allowed them to survive early attempts at the Africanization of industry. Africans, now supported by the formal institutions of the state, still found it difficult to engage in manufacturing because they lacked the informal networks that support trade and credit. The analysis is supported by the results of a contemporary survey of 120 manufacturing firms in Nairobi's metal sector that highlight the division between smaller African firms and larger Asian ones.

There are competing theories to explain the reasons behind the international competitiveness of manufacturing in Asia. Analysing these different theories will bring important lessons, not just for Asia, but for developing economies the world over. This lucid book studies industries and firms in East Asia and examines the major determinants of their economic performance. With contributions from such leading thinkers as Ha-Joon Chang and Rajah Rasiah, the book covers such themes as: *industrial policy and East Asia *Taiwan's information technology industry *The role of the government in technological capability building Manufacturing Competitiveness in Asia touches on many important themes and issues and as such will be of great interest to students, academics and policy-makers involved in industrial economics, international trade and Asian studies.

The last 20 years have brought remarkable growth and change to the sporting goods industry. The term ""sporting goods"" once comprised only equipment like golf clubs, basketballs and tennis rackets. With the recent explosion in apparel and footwear sales, though, the industry has moved far beyond equipment manufacture. Skyrocketing marketing budgets have resulted in top-name athletic endorsements and relentless branding, and athletic companies' logos are now easily among the most recognizable corporate trademarks in world. This work, both a valuable text for students and an indispensable handbook for professionals, offers insight into every major function of the sporting goods industry. Chapters cover the development of the industry; the industry's structure and size; manufacturers' products and market shares; channels of distribution; sports medicine and product liability; sports marketing, including licensing, endorsement and sponsorship; the use of traditional media and market research; sales trends and profitability; and e-commerce. Each chapter includes discussion questions and exercises. Appendices provide directories of sporting goods vendors, retailers, and multi-sport media and trade associations.

This is the first comprehensive guide to green design using economic input-output life cycle assessment (EIO-LCA) models. It is a must-have for companies trying to improve the environmental profile of their products and processes, for regulators attempting to quantify life cycle implications of products and services, and for students and scholars of green design.

Environmental life cycle assessment is often thought of as "cradle to grave" and therefore as the most complete accounting of the environmental costs and benefits of a product or service. However, as anyone who has done an environmental life cycle assessment knows, existing tools have many problems: data is difficult to assemble and life cycle studies take months of effort. A truly comprehensive analysis is prohibitive, so analysts are often forced to simply ignore many facets of life cycle impacts. But the focus on one aspect of a product or service can result in misleading indications if that aspect is benign while other aspects pollute or are otherwise unsustainable.

This book summarizes the EIO-LCA method, explains its use in relation to other life cycle assessment models, and provides sample applications and extensions of the model into novel areas. A final chapter explains the free, easy-to-use software tool available on a companion website. The software tool provides a wealth of data, summarizing the current U.S. economy in 500 sectors with information on energy and materials use, pollution and greenhouse gas discharges, and other attributes like associated occupational deaths and injuries.

This reference text discusses fundamentals, classification, principles, applications of additive and subtractive manufacturing processes in a single volume. The text discusses 3D printing techniques with the help of practical case studies, covers rapid tooling using microwave sintering and ultrasonic assisted sintering process, and covers different hybrid manufacturing techniques like cryo-MQL, and textured cutting inserts. It covers important topics including green manufacturing, ultrasonic assisted machining, electro thermal based non-conventional machining processes, metal based additive manufacturing, LASER based additive manufacturing, indirect rapid tooling, and polymer based additive manufacturing. The book: Discusses additive and subtractive manufacturing processes in detail Covers hybrid manufacturing processes Provides life cycle analysis of conventional machining Discusses biomedical and industrial applications of additive manufacturing The text will be useful for senior undergraduate, graduate students, and academic researchers in areas including industrial and manufacturing engineering, mechanical engineering, and production engineering. Discussing the sustainability aspects of conventional machining in reducing carbon footprint of machining by adopting different hybrid and non-conventional machining processes, this text will be useful for senior undergraduate, graduate students, and academic researchers in areas including industrial and manufacturing engineering, mechanical engineering, and production engineering.

Today's fast-paced manufacturing culture demands a handbook that provides how-to, no-holds-barred, no-frills information. Completely revised and updated, the Handbook of Manufacturing Engineering is now presented in four volumes. Keeping the same general format as the first edition, this latest edition not only provides more information but makes it more accessible. Each individual volume narrows the focus while broadening the coverage, giving you immediate access to the information you need. Volume Three, Parts Fabrication: Principles and Process discusses efficient deductive and systematic approaches to machine debugging while providing a refresher on the principles of structural mechanics. Edited by Richard Crowson with contributions from experts in each field, the book focuses on establishing communication between manufacturing and design engineers and machine-building technicians. The discussions of engineering design fundamentals, free-body diagrams, stresses, forces, and strength of materials help readers understand and solve counter-intuitive problems. The coverage includes material characteristics of metals, conventional fabrication processes, laser welding, modeling, and nontraditional machining methods. Assisting design engineers and machine builders in the successful execution of their tasks, the book recommends steps to improve technical problem solving and communication techniques. It provides understanding of how to incorporate deductive reasoning, systematic engineering, human interaction, and corporate cultural influences into manufacturing processes.

History is replete with examples of one political system replacing another, one scientific discovery invalidating another - and this cycle has occurred repeatedly in the production of goods and products for society. This book, first published in 1998, examines the massive transition currently taking place: the decline of the system of mass manufacturing. Various global changes in American business and manufacturing have forced a review of accepted thinking, and this book is a key text in this evaluation.

On economies of scale during the nineteenth century, much is assumed, but little is known. This study, first published in 1985, seeks to close this gap in our knowledge by providing comprehensive empirical evidence on the status of economies of scale in mid-nineteenth century manufacturing industry. This evidence is in the form of production function estimates made using data from the manuscripts of the federal censuses of manufacturing for 1850, 1860 and 1870.

Today's fast-paced manufacturing culture demands a handbook that provides how-to, no-holds-barred, no-frills information. Completely revised and updated, the "Handbook of Manufacturing Engineerin"g is now presented in four volumes. Keeping the same general format as the first edition, this second edition not only provides more information but makes it more accessible. Each individual volume narrows the focus while broadening the coverage, giving you immediate access to the information you need. Volume One, Product Design and Factory Development reveals how human factors deeply affect productivity in the workplace and why the modern manufacturing engineer must be well versed in these areas.

Edited by Richard Crowson with contributions from experts in each field, the book considers historical data for anthropometry and explores the impact of injuries, product liability, and low productivity on product cost. The book sequentially outlines the basic concepts of reliability theory in six chapters along with commonly used statistical methods for evaluating component reliability. It covers rapid prototyping, explores the machine debugging and troubleshooting process, and devotes an entire chapter to computers and controllers.

The challenges presented by the fiercely technical world we live and work in are met by the manufacturing engineer. Companies can no longer afford to allow the manufacturing engineer to learn on the job. Therefore, the manufacturing engineer must gain as much knowledge from as many credible sources as possible. Covering the global picture of manufacturing, this book shows you how to successfully apply manufacturing engineering skills on the job.

The capital goods industries--machinery, electrical and electronic equipment, transport equipment (except automobiles), and instruments and related equipment--provide more than one-third of total U.S. exports. But in the past twenty years, these industries have displayed a continual weakening of their competitive position. In this study, Robert Eckley investigates this leading sector of the American economy and its competition for global markets by concentrating on case studies of seven companies that represent the principal segments of the capital goods industries.

The approach that Eckley takes is an empirical one, utilizing the experience of IBM, Boeing, General Electric, Eastman Kodak, Caterpillar, Cummins, and Cincinnati Milacron to illustrate the developments that have occurred in this sector of the world economy. The companies are all leaders within their industries, and also offer a representative variety of the products, processes, and labor organizations found in the capital goods industries. Following a detailed introduction, Eckley devotes one chapter to each of the seven companies, seeking out commonalities within the larger capital goods sector and drawing conclusions about costs, markets, and organizational and managerial practices. A concluding chapter focuses on the keys to regaining American leadership: increasing capital investment, remedying educational deficiencies, and improving business decisions. Marketing and planning executives in international business will find this work to be an invaluable resource, as will students in business and public policy courses.

Basic Manufacturing has already established itself as a core text for manufacturing courses in Further Education. The new edition has been revised to be fully in line with the new Vocational GCSE in Manufacturing from Edexcel, covering the three compulsory units of this scheme, and will continue to act as a core text for Intermediate GNVQ. Coverage of the two schemes is combined throughout the text, yet each chapter clearly illustrates which sections map to which units within the two scheme specifications.
The author's approach is student-centred with self-check questions and activities provided throughout. As a result, the book is well suited to independent study. It is also clearly written to appeal to students of all abilities. Review questions are provided at the end of each chapter to consolidate learning and give practice for external assessments.
The third edition contains a brand new chapter to cater for the examinable part of the GCSE syllabus (Unit 3), which includes case studies in the six sectors covered in the scheme: food and drink/biological and chemical; printing and publishing/paper and board; textiles and clothing; engineering fabrication; mechanical/automotive engineering; electrical and electronic engineering/computer/process control/telecommunications.
The book is an excellent, readable introduction to the technical and business aspects of the manufacturing industry that will be invaluable for students on a wide range of courses, including City and Guilds certificates. It also provides a good grounding for students embarking on higher-level programmes within Manufacturing.
Roger Timings is one of the UK's leading authors of textbooks on manufacturingand engineering.
* Unit by unit match to the new Vocational GCSE in Manufacturing from Edexcel
* Core text also meets the requirements of Intermediate GNVQ Manufacturing
* Student-friendly approach, with numerous examples, case studies, and problems included throughout

This book provides the latest models, methods and guidelines for networked enterprises to enhance their competitiveness and move towards innovative high performance and agile industrial systems.In the new global market, competitiveness and economic growth rely greatly on the move toward innovative high performance industrial systems and agile networked enterprises through the creation and consolidation of non-hierarchical manufacturing networks of multi-national SMEs as opposed to networks based on powerful large-scale companies. Network performance can be significantly improved through more harmonious and equitable peer-to-peer inter-enterprise relationships, conforming decentralized and collaborative decision-making models.Traditional hierarchical manufacturing networks are based on centralized models, where some of the actors involved must adapt themselves to the constraints defined by those who are most dominant. Real-world experiences of such models have revealed some major problems due to the centralized vision of the supply chain and the sub-optimal performance of centralized decision-making. For the current highly dynamic markets, this generates major inefficiencies in operation throughout the supply chain.This book collects the latest research regarding non-hierarchical manufacturing networks and provides enterprises with valuable models, methods and guidelines to improve their competitiveness.

This volume comprehensively captures trends in productivity and its determinants in the post-reform period for Indian manufacturing. It provides an up-to-date survey of different methods employed in measuring productivity and their applications across organized and unorganized sectors, including food, beverages, furniture, gems, chemicals, petroleu

Originally published in 1992, Capital Mobilization and Regional Financial Markets, argues that barriers to financial flows within regions may be as important in affecting capital flows as interregional barriers. The book conjectures that regional markets allow efficient mobilization of local funds and develops an analytical framework to motivate an investigation of region financial development in the Pacific Coast states between 1850 and 1920.

Originally published in 1991, Financial Market Liberalization in Chile, 1973-1982, analyses the liberalization of the financial market which took place during the 1973-1982 monetarist experiment. The book addresses the effect this had on the Chilean economy and how this affected effects of the behaviour of the firms which went bankrupt during this period. The book also presents a description of the policies implemented in the Chilean economy during this period and examines the impact that this had on the performance of the financial sector.

This short history tells the story of five hundred years of papermaking against the general background of the coming of paper and printing in Britain, through the major developments of the Industrial Revolution, up to the technological advances which have made possible the enormous high-speed paper machines of the present day.