Selected as a Doody's Core Title for 2022! Delivering the most up-to-date information available in a rich, engaging presentation, Medical Physiology: Principles for Clinical Medicine, 6th Edition, instills a complete understanding of physiology essential to effective clinical practice. This robust text not only details how the human body reacts to internal and external changes but also provides a deep understanding of how physiologic systems coordinate to maintain optimal health, as well as the involvement of altered functions in disease processes. Extensively updated throughout and fully aligned with today's medical curriculum, the 6th Edition emphasizes the physiologic principles key to understanding human function, places them in their fundamental context in clinical medicine, and provides opportunities for student self-directed and team-based learning through case studies, clinical application exercises, and board-style review questions. NEW! Physiology of Aging and Organ Function chapter details the impact of aging on the body as it relates to human function. New and revised content throughout familiarizes you with the latest perspectives on cardiovascular physiology, neuromuscular physiology, gastrointestinal physiology, endocrine physiology, exercise physiology, and more. Updated USMLE-style review questions with answers provide valuable self-assessment and board exam prep. Clinical Focus essays clarify how and where physiology relates to clinical medicine and diagnosis. Integrated Medical Sciences essays alert you to important connections between physiology and other basic sciences. Clinical Applications exercises offer practice applying clinical knowledge and solving problems. Conceptual diagrams strengthen comprehension of difficult concepts and present both normal and abnormal clinical conditions. Active Learning Objectives, Chapter Summaries, and full-color artwork and tables make learning engaging and efficient. Additional online resources provide instant access to animations, additional review questions, additional clinical application exercises, advanced clinical problem-solving exercises, and suggested readings.

This book explores several subtypes of muscarinic receptors that modulate smooth muscle activity. Main topics include a classification of muscarinic receptors, biochemical responses that occur in smooth muscle, the role of muscarinic receptors in the function of gastrointestinal and genitourinary smooth muscle, and prejunctional muscarinic receptors in smooth muscle. Discussions cover the current state of research and are intended to generate further research into the design of novel therapeutics for disorders of smooth muscle function.

Although 20 million Americans are affected by thyroid disease (85 per cent of them women), misinformation about the disease continues to spread. An up-to-date comprehensive resource, this book helps readers understand just what is, and is not, thyroid disease. Including recent medical developments, patient profiles, photos and illustrations, and a section on 'Thyroid Newsmakers' -- from Muhammed Ali to Joe Piscopo -- the book contains answers to all the questions you think of after you leave the doctor's office.

Nutrition and Health: Topics and Controversies explores in detail the relationship between diet, nutritional status, and disease, and evaluates nutritional practices intended to minimize the incidence of and slow the progress of major chronic illnesses. National trends in nutritional awareness and the resulting changes in consumer behavior are discussed. Unlike other books on this subject, the authors take a stand on controversial issues in the field and document their positions with scientific data. Nutrients such as calcium, vitamin E, selenium, and antioxidants, their importance in overall nutrition, and their role in specific diseases are covered. Expertise in nutritional science is not required to gain the highly practical information in this book.

How do our muscles produce energy for exercise and what are the underlying biochemical principles involved? These are questions that students need to be able to answer when studying for a number of sport related degrees. This can prove to be a difficult task for those with a relatively limited scientific background. "Biochemistry for Sport and Exercise Metabolism" addresses this problem by placing the primary emphasis on sport, and describing the relevant biochemistry within this context.

The book opens with some basic information on the subject, including an overview of energy metabolism, some key aspects of skeletal muscle structure and function, and some simple biochemical concepts. It continues by looking at the three macromolecules which provide energy and structure to skeletal muscle - carbohydrates, lipids, and protein. The last section moves beyond biochemistry to examine key aspects of metabolism - the regulation of energy production and storage. Beginning with a chapter on basic principles of regulation of metabolism it continues by exploring how metabolism is influenced during high-intensity, prolonged, and intermittent exercise by intensity, duration, and nutrition.

Key Features: A clearly written, well presented introduction to the biochemistry of muscle metabolism.Focuses on sport to describe the relevant biochemistry within this context.In full colour throughout, it includes numerous illustrations, together with learning objectives and key points to reinforce learning.

"Biochemistry for Sport and Exercise Metabolism" will prove invaluable to students across a range of sport-related courses, who need to get to grips with how exercise mode, intensity, duration, training status and nutritional status can all affect the regulation of energy producing pathways and, more important, apply this understanding to develop training and nutrition programmes to maximise athletic performance.

This book explores the role calcium signaling plays in cellular responses in almost all types of cells including airway smooth muscle cells. This universal signaling may result from extracellular calcium influx and/or intracellular calcium release, which are precisely controlled and regulated by ion channels, exchangers and/or transporters on the plasmalemmal or sarcoplasmic reticulum membrane. First, several chapters detail calcium release channels (ryanodine receptors and inositol trisphosphate receptors), voltage-dependent potassium channels, transient receptor potential channels, Orai channels, calcium-activated potassium channels, and calcium-activated chloride channels. Well-characterized sodium-calcium exchangers, voltage-dependent calcium channels, and calcium pumps are described also in depth over many chapters.

Ca2+ signaling can be expressed in Ca2+ sparks, waves, oscillations, and global changes in intracellular Ca2+ concentration. Calcium in subcellular compartments (cytosol, sarcoplasmic reticulum, mitochondria, and caveolae) also exhibit dynamic crosstalk. Many molecules including FK506 binding proteins, cyclic adenosine diphosphate ribose, reactive oxygen species, RhoA kinases, caveolin and integrins can modify and induce spatial, temporal and compartmental variations of calcium signaling. In addition, calcium signaling can exhibit sex hormone- and age-dependent changes. A number of chapters are dedicated to covering these diverse formats, spatiotemporal characteristics, multifaceted network and mathematical modeling of Ca2+ signaling.

Neurotransmitters, hormones, growth factors, inflammatory cytokines, and other stimuli may lead to multiple cellular responses by inducing Ca2+ signaling in airway smooth muscle cells. Increasing evidence suggests that Ca2+ pumps and canonical transient receptor potential channels are essential for airway smooth muscle remodeling. Accordingly, several chapters summarize recent advances in the studies of the key role of calcium signaling in physiological cellular responses as well as the development of asthma, chronic obstructive pulmonary disease and other respiratory disorders.

The series CNS Neurotransmitters and Neuromodulators is destined to be the definitive reference work on the physiology and pharmacology of the central nervous system. Written by an outstanding group of international authors, chapters cover a wide range of interdisciplinary aspects of the subject.
This first volume includes an in-depth examination of acetylcholine, ranging from the localization of synthetic enzymes through electrophysiology, pharmacology, and molecular biology to behavioral importance in learning and memory. This indispensable and comprehensive reference keeps you abreast of new developments in several areas of neuroscience.

Introduction to Computational Cardiology provides a comprehensive, in-depth treatment of the fundamental concepts and research challenges involved in the mathematical modeling and computer simulation of dynamical processes in the heart, under normal and pathological conditions.

About this textbook:

- Presents descriptions of models used in both biology and medicine for discovering the mechanisms of heart function and dysfunction on several physiological scales across different species.

- Provides several examples throughout the textbook and exercises at the end which facilitate understanding of basic concepts and introduces, for implementation, treated problems to parallel supercomputers.

Introduction to Computational Cardiology serves as a secondary textbook or reference book for advanced-level students in computer science, electrical engineering, biomedical engineering, and cardiac electrophysiology. It is also suitable for researchers employing mathematical modeling and computer simulations of biomedical problems.

Although work furniture has had so much more attention recently there is a long way to go before this is translated into action in the wider world. Increased international concern for the health and safety of people at work is one of the driving forces behind this book.; The Science of Seating brings together researchers in ergonomics and posture with industrial designers, to review and assess the current state of chair design, with implications for cultural, behavioural and occupational aspects of health. The contributions are a significant step in the science of seating and should lead to a better understanding of the mechanics, dynamics and the effects of seating on the sitter.; They point to ways in which seats might become easier-to-use and adjust, offering both comfort and postural support without compromising freedom of movement: and in the not-too-distant furture, "the intelligent chair" will "remember" the sitter's preferences for position, cushiness and so on.; Topics covered include: Adjustability, Anthropometics, Posture, Back Pain, Biomechanics, Seat Pressure Distributions, School children, Special Needs of Users, Design Applications, Industry Perspectives, VDT Standards.; It is aimed at researchers and practising seating designers, ergonomists, design engineers, occupational health workers and physiotherapists and furniture manufacturers.

Ideal as a companion to the text. Perfect as a stand-alone study guide. Body system by system, the exercises and activities you'll find inside will help you to master the basics of anatomy and physiology. Complete the corresponding sections of the Workbook as you proceed from topic to topic in class. See what students are saying online... Cut my study time in half! "This workbook cut my study time in half and helped me to be better prepared for the exam. I was shocked when my score went from 80 to 90 just after one exam!" Great workbook and super easy to understand. "Great workbook and super easy to understand. I love the layout of it and the work in the book follows right along with the book !!! I love it!!" - Brittany S. *Student Workbook answers are available for students in the back of the book

Sport, Recovery and Performance is a unique multi-disciplinary collection which examines both the psychological and physiological dimensions to recovery from sport. Including contributions from medicine, neuroscience, psychology and sport science, the book expertly explores the implications for applied and strategic interventions to both retain and stabilize performance, and promote health and well-being. Including chapters written by its leading experts, the book represents an important milestone in this evolving field of study. It covers issues around measuring recovery, the impact of overtraining on sleep and mental health, and addresses topics such as the impact of travel on performance. The book informs not only how managing recovery can improve performance, but also offers insights in how recovery can sustain athletes' physical and mental health. Citing research from a range of individual and team sports, as well as extreme situations and the workplace, this is an important book that will be widely read across the sport sciences.

Whether you're a clinician concerned with patient management, a technician involved in diagnostic testing, or an investigator studying fibrinogen structure and function, you'll find that the 1994 Index of Variant Human Fibrinogens. is a valuable resource. It contains not only the most comprehensive compilation of the world literature and research on dyfibrinogenemia, but also includes a synopsis for health professionals and expert guidance for the diagnosis and treatment of dysfibrinogenemia, the study of genetically abnormal human fibrinogens. Furthermore, this book provides the latest DNA and protein sequences (including the AaE chain) and listings of available PCR primers and anti-fibrinogen antibodies. Add to this a set of 263 Dysfibrinogen Reports tracking more than 30 different characteristics for each variant, plus 9 summary tables and a comprehensive bibliography, and the result is an authoritative companion for the diagnosis and management of this multifaceted and complex disease.
Compare your patient's laboratory profile, clinical manifestations, or molecular defect with virtually all others in the literature. Consider all the options for treating bleeding or thrombotic complications. Determine if your data from a newly identified variant are unique. Spend an hour with this book and see if it doesn't save many hours of literature searching and summarizing

Audience
Applied biomathematicians, orthopedists, clinical orthopedists.

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed. This volume focuses on hormone and transport systems.

This new study guide is a companion to the bestselling textbook Fundamentals of Anatomy and Physiology for Nursing and Healthcare Students, and is designed to help and support you with this subject area, by testing and consolidating your knowledge of anatomy and physiology. Jam-packed with tips, hints, activities and exercises, this workbook will guide you through the core areas of anatomy and physiology, and provide you with loads of help with your studies. Designed to support all styles of learning, Fundamentals of Anatomy and Physiology Workbook provides you with a wide range of activities including: * Clear illustrations for tracing, copying, shading and colouring in * Blank diagrams for labelling * Multiple choice questions * Fill in the gap exercises * Learning tips and hints * Crosswords * Word searches Also available: Fundamentals of Anatomy and Physiology for Nursing and Healthcare Students 2nd edition the bestselling textbook upon which this study guide is based.

This reference work brings together the biology, mechanics, neurophysiology and pathophysiology of diseased joints, illustrates available physiologically-based treatments for osteoarthrosis and explains how and when to use them.;Highlighting the most up-to-date biomechanical principles, Mechanics of Human Joints: discusses the functional anatomy of joints; relates the neurophysiology of joints to ligamentous reconstruction; elucidates the pathophysiology of osteoarthrosis; summarizes the latest information on muscle physiology and electromyography; examines the effect of vibration and impulsive loading on joint pathology; and explicates the principles of prosthetic joint replacement.

Binder-Ready Edition: This loose-leaf copy of the full text is a convenient, accessible, and customizable alternative to the bound book. With this binder-ready edition, students can personalize the text to match their unique needs! Develop the strong foundation in pathophysiology you need to guide your patient care! Exploring the etiology, pathogenesis, clinical manifestations, and treatment of diseases and disorders, Pathophysiology, 7th Edition focuses on the major alterations in the homeostasis of body systems to provide you with a unifying framework. Current scientific findings and relevant global research are integrated throughout the book, with chapters organized by body system, beginning with an illustrated review of anatomy and normal physiology. Each chapter includes a discussion of the disease processes and abnormalities that may occur, with a focus on the pathophysiologic concepts involved. Practical learning resources emphasize critical thinking and help simplify this rigorous subject. Updated, full-color illustrations and photos throughout enable you to visualize disease and disease processes and gain a clearer understanding of the material. Easy-to-read style is simplified by input from readability experts, and includes many tables, boxes, and figures to highlight key content. Thorough content updates include the latest information on new treatment advances, over 100 new figures for improved clarity, and much more throughout the text. Global Health Care boxes highlight global healthcare concerns such as COVID-19, HIV/AIDS, Ebola, and more, with information on prevalence, mechanism of disease, and transmission. User-friendly learning resources in the text include chapter outlines, bolded key terms, key questions, Key Points boxes, Clinical Judgment challenges, and chapter summaries. Pediatric and Geriatric Considerations boxes include brief analyses of age-related changes associated with specific body systems. More than 1,000 illustrations help clarify complex pathophysiological concepts and make the book visually appealing. NEW! Next Generation NCLEX (R) (NGN)-style case studies on the companion Evolve website help strengthen your clinical judgment skills in preparation for the new item types on the exam. NEW! COVID-19 coverage includes the most current scientific findings, prevalence, mechanism of disease, transmission, and treatment implications.

Human intelligence isn’t just located in the brain. Our bodies are marvelously sophisticated and complex, with a variety of autonomic systems that help maintain our health without us ever having to think about them. But how exactly do all these physiological structures actually work?   In Our Intelligent Bodies, physiology professor Gary F. Merrill takes you on a guided tour through the human body. You’ll learn how our eyes are designed to detect unimaginably small bursts of light and how our ears contain bundles of tiny hairs, each one attuned to different sound frequencies. You’ll also discover how our hearts are smart enough to compensate for skipped beats and irregular rhythms and how our pulmonary system adjusts for low oxygen levels. You’ll even find out why the gut is sometimes called the “second brain,� its reflexes controlled by millions of neurons.      Written in a fun, easy-to-comprehend style and filled with illuminating analogies, Our Intelligent Bodies also brings readers up to date on cutting-edge research into the wonders of human physiology. It will give you a new appreciation for the smart decisions our bodies are making when our brains aren’t paying attention.

Selected as a Doody's Core Title for 2022! Lippincott (R) Connect Featured Title Purchase of the new print edition of this Lippincott (R) Connect title includes access to the digital version of the book, plus related materials such as videos and multiple-choice Q&A and self-assessments. Praised for its concise coverage, this highly accessible monograph lays a foundation for understanding the underlying concepts of normal cardiovascular function and offers a welcome alternative to a more mechanistically oriented approach or an encyclopedic physiology text. Clear explanations, ample illustrations and engaging clinical cases and problems provide the perfect guidance for self-directed learning and prepare you to excel in clinical practice. Chapter Learning Objectives highlight key concepts at a glance. Problems and Clinical Cases with Answers to Problems reinforce fundamental physiological concepts. Summary of Important Concepts boxes provide bulleted quick-review of essential chapter content. Multiple-choice Review Questions and Answers to Review Questions (with full explanations for each answer choice) enable self-assessment and alert you to areas requiring further study. A chapter on Cardiovascular Integration, Adaptation, and Pathophysiology integrates cardiovascular concepts in the context of normal and clinically relevant conditions. Lippincott (R) Connect features: Full access to the digital version of the book with the ability to highlight and take notes on key passages for a more personal, efficient study experience. Carefully curated resources, such as interactive diagrams, audio and video tutorials, and self-assessment, all designed to facilitate further comprehension. Lippincott (R) Connect also allows users to create Study Collections to further personalize the study experience. With Study Collections you can: Pool content from books across your entire library into self-created Study Collections based on discipline, procedure, organ, concept or other topics. Display related text passages, video clips and self-assessment questions from each book (if available) for efficient absorption of material. Annotate and highlight key content for easy access later. Navigate seamlessly between book chapters, sections, self-assessments, notes and highlights in a single view/page.

The groundbreaking science behind the surprising source of good health Stanford University's Justin and Erica Sonnenburg are pioneers in the most exciting and potentially transformative field of human health and wellness, the study of the relationship between our bodies and the trillions of organisms representing thousands of species to which our bodies play host, the microbes we call the microbiota. The Sonnenburgs argue that the microbiota determines in no small part whether we're sick or healthy, fit or obese, sunny or moody-and that the microbiota has always been with us, coevolving with humans and entwining its functions with ours. They show us that humans are really composite organisms with microbial and human parts. But now, because of changes to diet, antibiotic over-use, and over-sterilization, our gut microbiota is facing a "mass extinction event," which may explain the mysterious spike in some of our most troubling modern afflictions, from food allergies to autism, cancer to depression. It doesn't have to be this way. The Good Gut is a groundbreaking work that offers a new plan for health that focuses on how to nourish your microbiota, including recipes and a menu plan. The Sonnenburgs show how we can keep our microbiota off the endangered species list and strengthen the community that inhabits our gut and thereby improve our own health. In this important and timely investigation, they look at safe alternatives to antibiotics; dietary and lifestyle choices to encourage microbial health; the management of the aging microbiota; and the nourishment of your own individual microbiome. Caring for our gut microbes may be the most important health choice we can make.

Unless new discoveries are made in the prevention or treatment of stroke, Alzheimer's Disease and depression, the number of patients with these diseases is sure to increase dramatically by the year 2050. Thus, developing strategies to retard or delay the onset of stroke, AD and depression these neurological disorders is of critical important. The present monograph will provide current and comprehensive information on the relationship between neuroinflammation and oxidative stress in age-related neurological disorders at the molecular level. The information described in this monograph on lifestyle (diet and exercise), genes and age is intended to facilitate and promote new discoveries for the treatment of age-related neurological disorders.

Biophysics is the science of physical principles underlying all processes of life, including the dynamics and kinetics of biological systems.

This fully revised 2nd English edition is an introductory text that spans all steps of biological organization, from the molecular, to the organism level, as well as influences of environmental factors. In response to the enormous progress recently made, especially in theoretical and molecular biophysics, the author has updated the text, integrating new results and developments concerning protein folding and dynamics, molecular aspects of membrane assembly and transport, noise-enhanced processes, and photo-biophysics. The advances made in theoretical biology in the last decade call for a fully new conception of the corresponding sections. Thus, the book provides the background needed for fundamental training in biophysics and, in addition, offers a great deal of advanced biophysical knowledge.

"Concise Human Physiology" is written for medical students and presents the main facts in a concise, straightforward style. The first edition received an encouraging reception from students, especially those for whom English is a foreign language. The presentation of major subjects in manageable chapter lengths makes the book most attractive to students who find some books rather lengthy due to detail and the inclusion of information not required by the medical curriculum.

This second edition is more focused and has made use of valuable feedback from students and teachers who have been using the book over the last few years. All the chapters have been thoroughly revised and new illustrations and summary diagrams have been added.

Fundamentals of Pediatric Imaging, Third Edition presents the foremost techniques of pediatric medical image analysis and processing. It includes advanced imaging techniques, neuro applications, and highlights basic anatomy needed to understand this complex specialty. The book introduces the theory and concepts of pediatric digital image analysis and newly revised information on quality and safety topics, imaging modalities, imaging applications, and new discoveries in diseases and treatments. The newly revised edition provides updates in areas of expertise including neurologic, musculoskeletal, cardiac, chest, and GU imaging. Edited by Lane F. Donnelly, MD, recipient of the Society of Pediatric Radiology's 2009 Singleton-Taybi Award, this book is sure to be a prime reference in pediatric medical imagining.

Presented as a series of lectures, this important volume achieves four major goals:
1) It integrates the results of the author's research as applied to pattern perception -- reviewing current brain research and showing how several lines of inquiry have been converging to produce a paradigm shift in our understanding of the neural basis of figural perception.
2) It updates the holographic hypothesis of brain function in perception.
3) It emphasizes the fact that both distributed (holistic) and localized (structural) processes characterize brain function.
4) It portrays a neural systems analysis of brain organization in figural perception by computational models -- describing processing in terms of formalisms found useful in ordering data in 20th-century physical and engineering sciences.
The lectures are divided into three parts: a Prolegomenon outlining a theoretical framework for the presentation; Part I dealing with the configural aspects of perception; and Part II presenting its cognitive aspects. The appendices were developed in a collaborative effort by the author, Kunio Yasue, and Mari Jibu (both of Notre Dame Seishin University of Okayama, Japan).