Selected as a Doody's Core Title for 2022! Lippincott (R) Connect Featured Title Purchase the new print edition of this Lippincott (R) Connect title includes access to the digital version of the book, plus related materials such as videos and multiple-choice Q&A and self-assessments. Reflecting the trusted expertise of Dr. John B. West and Dr. Andrew M. Luks, West's Pulmonary Pathophysiology: The Essentials, Tenth Edition offers accessible explanations of disease processes that affect the respiratory system. This best-selling companion to West's Respiratory Physiology: The Essentials, 11th Edition, has served generations of students and practitioners who work with respiratory patients, presenting vital knowledge in a concise, straightforward manner that's easy to understand. Building on this legacy of success, the tenth edition is updated throughout with the latest clinical perspectives, new images, clinical vignettes, and enhanced USMLE-style review questions to help students excel in today's changing healthcare practice. UPDATED! Clinical Vignettes with open-ended questions demonstrate the real-world application of basic science and strengthen students' self-assessment. UPDATED! Radiographs, CT images, and color histopathologic sections clarify diagnostic and therapeutic approaches. UPDATED! USMLE-style multiple-choice questions, with answers, at the end of each chapter reveal areas requiring further study and boost students' test-taking confidence. Clinical features/notes boxes provide efficient, bulleted review for key diseases. End-of-chapter Key Concepts reviews reinforce essential chapter information at a glance. Appendices provide fast access to symbols, units, and normal values; further readings; and answers to multiple-choice and Clinical Vignette questions. Online video lectures, available via YouTube, engage students in the material and clarify challenging textbook concepts. Lippincott (R) Connect features: Full access to the digital version of the book with the ability to highlight and take notes on key passages for a more personal, efficient study experience. Carefully curated resources, such as interactive diagrams, audio and video tutorials, and self-assessment, all designed to facilitate further comprehension. Lippincott (R) Connect also allows users to create Study Collections to further personalize the study experience. With Study Collections you can: Pool content from books across your entire library into self-created Study Collections based on discipline, procedure, organ, concept or other topics. Display related text passages, video clips and self-assessment questions from each book (if available) for efficient absorption of material. Annotate and highlight key content for easy access later. Navigate seamlessly between book chapters, sections, self-assessments, notes and highlights in a single view/page.

This book draws together important facts, in particular areas of vascular biology, and allows the generation of hypotheses and principles that unite an area and define newer horizons. It is designed for scientists and physicians interested in immunology, inflammation and cardiovascular diseases.

Measurement of Cardiac Function presents detailed descriptions of how to set up and use several classical cardiac preparations from scratch. The preparations include whole heart, atrial, ventricular, and papillary muscles and in vivo small animal preparations. Methods for monitoring contraction and contractility are fully described. Flow charts and step-by-step instructions make it easy to understand, even for the first time investigator.
This book examines the most widely used tools in experimental cardiology and provides you with the recipe-setting up the technique, procurement of equipment, sample data and calculations, problems and trouble shooting, adapting to other species, modifications, and applicability. Undoubtedly, this text will be a great asset to cardiovascular physiologists, pharmacologists, experimental cardiologists, and students of physiology and pharmacology.

This book summarizes present knowledge of different mechanisms involved in the development of positive and negative consequences of cardiac adaptation. Particular attention is paid to the still underestimated adaptive cardiac responses during development, to adaptation to the frequently occurring pressure and volume overload as well as to cardiac changes, induced by enduring exercise and chronic hypoxia. "Cardiac Adaptations" will be of great value to cardiovascular investigators, who will find this book highly useful in their cardiovascular studies for finding solutions in diverse pathological conditions; it will also appeal to students, fellows, scientists, and clinicians interested in cardiovascular abnormalities."

This book bridges the gap between a clinician's and material scientists' knowledge by elucidating upon the different biomaterials used in anatomical systems and how those materials react to the human body. It explores both established and future prospective of biomaterial types/designs, and considerations in material selection and synthesis, to guide students from non-clinical background in understanding the relations of material science and the human body.

The rapidly evolving field of protein science has now come to realize the ubiquity and importance of protein-protein interactions. It had been known for some time that proteins may interact with each other to form functional complexes, but it was thought to be the property of only a handful of key proteins. However, with the advent of high throughput proteomics to monitor protein-protein interactions at an organism level, we can now safely state that protein-protein interactions are the norm and not the exception. Thus, protein function must be understood in the larger context of the various binding complexes that each protein may form with interacting partners at a given time in the life cycle of a cell. Proteins are now seen as forming sophisticated interaction networks subject to remarkable regulation. The study of these interaction networks and regulatory mechanism, which I would like to term "systems proteomics," is one of the thriving fields of proteomics.

The bird-eye view that systems proteomics offers should not however mask the fact that proteins are each characterized by a unique set of physical and chemical properties. In other words, no protein looks and behaves like another. This complicates enormously the design of high-throughput proteomics methods. Unlike genes, which, by and large, display similar physico-chemical behaviors and thus can be easily used in a high throughput mode, proteins are not easily amenable to the same treatment. It is thus important to remind researchers active in the proteomics field the fundamental basis of protein chemistry. This book attempts to bridge the two extreme ends of protein science: on one end, systems proteomics, whichdescribes, at a system level, the intricate connection network that proteins form in a cell, and on the other end, protein chemistry and biophysics, which describe the molecular properties of individual proteins and the structural and thermodynamic basis of their interactions within the network.

Bridging the two ends of the spectrum is bioinformatics and computational chemistry. Large data sets created by systems proteomics need to be mined for meaningful information, methods need to be designed and implemented to improve experimental designs, extract signal over noise, and reject artifacts, and predictive methods need to be worked out and put to the test. Computational chemistry faces similar challenges. The prediction of binding thermodynamics of protein-protein interaction is still in its infancy. Proteins are large objects, and simplifying assumptions and shortcuts still need to be applied to make simulations manageable, and this despite exponential progress in computer technology.

Finally, the study of proteins impacts directly on human health. It is an obvious statement to say that, for decades, enzymes, receptors, and key regulator proteins have been targeted for drug discovery. However, a recent and exciting development is the exploitation of our knowledge of protein-protein interaction for the design of new pharmaceuticals. This presents particular challenges because protein-protein interfaces are generally shallow and interactions are weak. However, progress is clearly being made and the book seeks to provide examples of successes in this area.

The genome's been mapped.
But what does it mean?

Arguably the most significant scientific discovery of the new century, the mapping of the twenty-three pairs of chromosomes that make up the human genome raises almost as many questions as it answers. Questions that will profoundly impact the way we think about disease, about longevity, and about free will. Questions that will affect the rest of your life.

"Genome" offers extraordinary insight into the ramifications of this incredible breakthrough. By picking one newly discovered gene from each pair of chromosomes and telling its story, Matt Ridley recounts the history of our species and its ancestors from the dawn of life to the brink of future medicine. From Huntington's disease to cancer, from the applications of gene therapy to the horrors of eugenics, Matt Ridley probes the scientific, philosophical, and moral issues arising as a result of the mapping of the genome. It will help you understand what this scientific milestone means for you, for your children, and for humankind.

This volume, based on the International Congress Creatine: From Basic Science to Clinical Application, held in Milan on June 4, 1999, outlines the physiological role of creatine in the human body as well as its possible role in different pathological conditions. Creatine is already used as a dietary supplement to augment muscle performance in healthy individuals and inpatients with immobilizing diseases, such as complex fractures. There is also an increasing interest in its administration in a growing number of clinical conditions. A specific deficit of endogenous synthesis of creatine which responds to high dosage exogenous supplementation has been described. In cardiac failure and in chronic obstructive pulmonary disease, creatine improves the contractility of the muscular system. Promising effects of this substance have also been described in animal models of neurodegenerative disorders, such as amyotrophic lateral sclerosis, and in some mitochondrial cytopathies. This volume is of obvious interest to basic scientists working on the physiology of creatine and to clinicians interested in its medical indications.

Skin bioengineering is an expanding field of investigative and clinical dermatology. This guide describes all commercially available techniques and instruments. It provides a thorough overview of methods for noninvasive investigation of skin function. Commercially available instruments are reviewed and compared, with updated references given for each instrument. This book offers a technical analysis of each instrument, allowing investigators to understand its biophysical principles and to make better purchases of lab instruments. Addresses of manufacturers and worldwide distributors are included, making this an essential reference source.
Chapters are written by international experts. Topics include transepidermal water loss, hydration, the measurement of skin blood flow in Laser-Doppler flowetry, sebum, pH and ions, and transcutaneous pO2 and pO2 measurements. Skin color, roughness, and elasticity are examined in detail. Skin imaging techniques, capillaroscopy, and fluorescence videomicroscopy are described. Instruments for surface microscopy of the skin are also discussed.
Bioengineering of the Skin explains state-of-the-art techniques and is valuable reading for anyone who needs to stay abreast of the latest activities in this ever-changing field.

This handbook presents the most current information on the effects of ionizing radiation on mammalian cells, with emphasis on human tissues. The dose-effect relationship is emphasized in a quantitative manner. The book contains up-to-date data on the late effects of low levels of radiation on humans. It also provides some of the late consequences of radiation therapy detected among cancer survivors.

From the reviews of the first edition

Image-Based Computational Modeling of the Human Circulatory and Pulmonary Systems provides an overview of the current modeling methods and applications enhancing interventional treatments and computer-aided surgery. A detailed description of the techniques behind image acquisition, processing and three-dimensional reconstruction are included. Techniques for the computational simulation of solid and fluid mechanics and structure interaction are also discussed, in addition to various cardiovascular and pulmonary applications. Engineers and researchers involved with image processing and computational modeling of human organ systems will find this a valuable reference.

The Atlas of the Human Hypothalamus presents for the first time a detailed view of the cyto- and myeloarchitecture of the human hypothalamus. Providing high-resolution images of consecutive coronal sections, this book illustrates the brain area that is responsible for maintaining the homeostasis of the body by direct neuronal projections as well as by linking the central nervous system to the endocrine system. The primary goal of this atlas is to provide detailed morphological understanding of the hypothalamic structures that control numerous vital functions as well as to provide a tool to target hypothalamic areas during deep brain stimulation.

The impaired brain has often been difficult to rehabilitate owing to limited knowledge of the brain system. Recently, advanced imaging techniques such as fMRI and MEG have allowed researchers to investigate spatiotemporal dynamics in the living human brain. Consequently, knowledge in systems neuroscience is now rapidly growing. Advanced techniques have found practical application by providing new prosthetics, such as brain-machine interfaces, expanding the range of activities of persons with disabilities, or the elderly. The book's chapters are authored by researchers from various research fields such as systems neuroscience, rehabilitation, neurology, psychology and engineering. The book explores the latest advancements in neurorehabilitation, plasticity and brain-machine interfaces among others and constitutes a solid foundation for researchers who aim to contribute to the science of brain function disabilities and ultimately to the well-being of patients and the elderly worldwide.

This book describes control of ventilation during sleep in both health and disease states. The topics are presented in a fashion that can be easily comprehended with many figures to illustrate complex concepts. Thus, a wide range of topics, starting from the site of normal respiratory rhythm generation to chemoreceptor control of sleep apnea, description of the apneic threshold, pathophysiology of upper airway closure, novel techniques to measure control of breathing, effect of cerebral blood flow on breathing, effect of opioids on ventilation, effect of heart failure on ventilation, genetic aspects of breathing disorders, age and gender differences, and various therapies are discussed. Key Features * Helps to bridge the gap between straight forward physiology and clinical practice through a range of topics and use of case vignettes * Explores various aspects of clinical management and control which is beneficial to sleep clinicians, respiratory physiologists, intensivists, trainees, and researchers. * Distills complex concepts into understandable language and figures, providing helping resource to the clinicians, that transforms a dry topic vis a viz control of ventilation into an exciting understandable 'clinician' language.

Written by the authority on hypertrophic cardiomyopathy (HCM) and an HCM patient, and fully endorsed by the Hypertrophic Cardiomyopathy Association (HCMA), the leading advocacy and support organization, the 3rd Edition of this best-selling guide offers unparalleled insight into all aspects of living with and treating HCM.

Accessible and practical, A Guide to Hypertrophic Cardiomyopathy For Patients, Their Families and Interested Physicians 3rd Edition: Answers the most pressing questions posed by patients, their families, and non-specialistshealth professionals involved in their careCovers everything from what is HCM and initial diagnosis of this increasingly prevalentcondition to the latest treatment optionsReflects the first-ever HCM guidelines published by the American Heart Association in 2011

Eighteen contributions consider various aspects of pulmonary vascular control and the pulmonary vasculature's response to injury and disease. They discuss recent advances in molecular biology to cell proliferation, interactions between the endothelium and smooth muscle, and the etiologies of various

Our understanding of the molecular and cellular mechanisms that control skeletal muscle development, regeneration, and adaptive responses to activity has increased dramatically in recent years, fostered by innovative techniques and approaches that are either specifically designed or adapted for research in skeletal muscle biology. Myogenesis: Methods and Protocols presents detailed, step-by-step methods in the study of the molecular and cellular biology of skeletal muscle cells. Protocols from different model systems including mammalian, avian, zebrafish, and invertebrate skeletal muscle are included in this volume. Highlighted topics cover a wide range of interests and expertise including myogenic and stem cell isolation, investigation of models of exercise and disuse, viral vector delivery systems, calcium imaging, cell profiling, as well as protein-DNA and protein-protein interactions. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, Myogenesis: Methods and Protocols serves as an invaluable, state-of-the-art resource for experienced and emerging scientists in basic research as well as clinical and regenerative medicine.

: The second edition of this atlas has been revised and greatly en-larged to take account of recent diagnostic advances in the field of haematology. It contains 750 color photomicrographs of common and less common cell types, and is intended to supplement the per-sonal study of preparations under the microscope.: The photographs are grouped into five sections covering red cells and their precursors; nonerythroid cells of myeloid origin; lympho-cytes, plasma cells and their derivatives and precursors; miscella-neous cells of blood and marrow, including foreign cells and para-sites; and the imprint cytology of lymph nodes and spleen. Each section is preceded by a brief introduction, and an appendix pro-vides technical details of staining methods. The text accompanying the illustrations serves chiefly to identify the cells, but also gives explanations of certain unusual appearances and the cytochemical reactions where necessary.: A Colour Atlas of Haematological Cytology will be useful to students of medicine and medical laboratory science, as well as to doctors and technicians specializing in the diagnosis of haematological dis-ease.

Experts in neuropsychology examine key issues in research involving the frontal lobes.

Successfully learn to apply dental anatomy to the practice of dentistry with Wheeler's Dental Anatomy, Physiology, and Occlusion, 11th Edition. Updated and visually enhanced, the eleventh edition of this market-leading dental text expands its focus on clinical applications and includes dozens of online 360-degree and 3-D tooth animations to give you an unparalleled view of dentitions, pulp formation, the sequence of eruptions, and countless clinical considerations. Every text purchase also comes with access to the companion ExpertConsult website - where you can reference the entire text electronically as well as engage with a wealth of learning activities, animations, and hands-on resources to better understand and retain the information covered in your text. In all, this proven learning package offers all the up-to-date information, best practices, and tools to prepare you for the dental anatomy and occlusion section of the exams and ensure long-term clinical success. More than 800 full-color images include detailed, well-labeled anatomical illustrations as well as clinical photographs. Bolded key terms draw students' attention to essential terminology. Practical appendices include Review of Tooth Morphology with a concise review of tooth development from in utero to adolescence to adulthood; and Tooth Traits of the Permanent Dentition with tables for each tooth providing detailed information such as tooth notation, dimensions, position of proximal contacts, heights, and curvatures. 360-degree virtual reality and 3-D animations on Expert Consult help students refine their skills in tooth identification and examination. Step-by-step videos on Expert Consult demonstrate occlusal adjustments. Labeling exercises challenge students to identify tooth structures and facial anatomy with drag-and-drop labels. Chapter on clinical applications includes practical applications and case studies to prepare students for exams. Topics include root planing and scaling; extraction techniques and forces; relationship of fillings to pulp form and enamel form; and occlusal adjustment of premature occlusal contacts and arch form in relationship to bite splint designs. NEW! Learning objectives and pre-test questions at the start of every chapter focus students' attention on the knowledge and critical thinking expectations for each chapter. NEW! Full-color images have replaced many of the black and white images to give students a more vivid picture of clinical situations and procedures. NEW! Updated information incorporates new research and visuals to ensure students are equipped with the latest best practices. NEW! Access to the companion Expert Consult website includes hands-on exercises, animations, videos, quizzes, exams, and more to round out students' learning experience and help ensure their ability to apply book content.

First published in 1984. Routledge is an imprint of Taylor & Francis, an informa company.

Zika Virus Impact, Diagnosis, Control, and Models: Volume Two: The Neuroscience of Zika examines diagnosis, vaccines, and potential therapy methods for Zika virus syndrome. The book also details the neuroscience of Guillain-Barre syndrome, its effects and neuromuscular rehabilitation. It is designed to help readers better understand detection, therapies for Zika virus, preventative vaccines, diagnosis and associated microcephaly. Chapters on models enable further research and understanding. This book has applicability for neuroscientists, neurologists, virologists and anyone working to better understand the evolution and pathogenesis of Zika virus-related conditions.

This comprehensive volume spotlights the latest research into how and why the much-maligned and misunderstood Vitamin D is finally coming into its own, and how to gain the greatest benefits from it. Vitamin D keeps a range of chronic and life-threatening diseases at bay.