This book highlights the importance of the choroid plexus, which forms the blood-cerebrospinal fluid barrier and is the site of the major production of the cerebrospinal fluid (CSF). The authors show that this barrier is crucial for maintaining important compositional differences between the blood plasma and the CSF. The choroid plexus epithelial cells also prevent the spread of infectious agents and other blood-borne entities to the brain tissue. Chapter topics range from the production of CSF by electrolyte regulation in the choroid plexus, to details on the selectively transporting nature of this barrier. Further, the authors elaborate on the important roles of CSF in sustaining brain health by providing hydration, solutes, and nutrients to the brain tissue. Readers will also learn how CSF circulates signaling molecules within the compartments of the brain and removes waste products from the brain tissue. Elucidating the regulation of these processes in the choroid plexus is not only important for the readers' understanding of normal brain development and function, but is also crucial for resolving a variety of cerebral challenges that lead to brain edema, as well as developing treatments for diseases. The book discusses disease models like hydrocephalus, sleep disorders, and age-related dementia. Its comprehensive coverage makes this volume a valuable resource for researchers in cell and neurophysiology, as well as graduate students of the neurosciences.

Almost all bodily functions are dependent on activity of the autonomic nervous system - from the cardiovascular system, the gastrointestinal tract, the evacuative and sexual organs, to the regulation of temperature, metabolism and tissue defence. Balanced functioning of each aspect of this system is an important basis of our life and well-being. In this long-awaited second edition, the author, a leading figure in this field, provides an up-to-date and detailed description of the cellular and integrative organization of the autonomic nervous system, covering both peripheral and central aspects. The book exposes modern neurobiological concepts that allow us to understand why this system normally runs so smoothly and why its deterioration has such disastrous consequences. This broad overview will appeal to researchers and advanced undergraduate students of the various biological and medical sciences studying how the autonomic nervous system works and to clinicians and physical therapists whose practice involves systems dependent on autonomic functions.

As medical schools struggle to fit ever more material into a fixed amount of time, students need to approach the study of anatomy through a succinct, integrative overview. Rather than setting forth an overwhelming list of facts to be memorized, this book engages readers with a fascinating account of the connections between human anatomy and a wide array of scientific disciplines, weaving in the latest advances in developmental and evolutionary biology, comparative morphology, and biological engineering. Logically organized around a few key concepts, The Scientific Bases of Human Anatomy presents them in clear, memorable prose, concise tabular material, and a host of striking photographs and original diagrams.

Known for its clear presentation style, single-author voice, and focus on content most relevant to clinical and pre-clinical students, Guyton and Hall Textbook of Medical Physiology, 14th Edition, employs a distinctive format to ensure maximum learning and retention of complex concepts. A larger font size emphasizes core information, while supporting information, including clinical examples, are detailed in smaller font and highlighted in pale blue - making it easy to quickly skim the essential text or pursue more in-depth study. This two-tone approach, along with other outstanding features, makes this bestselling text a favorite of students worldwide. Offers a clinically oriented perspective written with the clinical and preclinical student in mind, bridging basic physiology with pathophysiology. Focuses on core material and how the body maintains homeostasis to remain healthy, emphasizing the important principles that will aid in later clinical decision making. Presents information in short chapters using a concise, readable voice that facilitates learning and retention. Contains more than 1,200 full-color drawings and diagrams - all carefully crafted to make physiology easier to understand. Features expanded clinical coverage including obesity, metabolic and cardiovascular disorders, Alzheimer's disease, and other degenerative diseases. Includes online access to interactive figures, new audio of heart sounds, animations, self-assessment questions, and more. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Clinics in Developmental Medicine No. 160

Children with craniosynostosis are born with congenital deformities of the face and skull. In severe cases associated problems are common. The child who is not properly cared for can end up blind, deaf and with severe learning difficulties. In addition, they may be left with unacceptable facial deformities. Outside specialized craniofacial units, there is at present nowhere for those involved in primary or secondary care to go for help with the many practical problems that these children present. In this book, a distinguished team of editors have assembled experts in the field to introduce the non-craniofacial specialist to what can be achieved and how they can contribute to the child's welfare. It will be essential reading for paediatricians seeking practical information about the management of these disorders, and for specialists in neurosurgery, ENT, ophthalmology, plastic surgery, maxillo-facial surgery, orthodontics, psychology, genetics, anaesthesia, audiology and speech therapy.

This book focuses on interdisciplinary research in the field of biomedical engineering and neuroscience. Biomedical engineering is a vast field, ranging from bioengineering to brain-computer interfaces. The book explores the system-level function and dysfunction of the nervous system from scientific and engineering perspectives. The initial sections introduce readers to the physiology of the brain, and to the biomedical tools needed for diagnostics and effective therapies for various neurodegenerative and regenerative disorders. In turn, the book summarizes the biomedical interventions that are used to understand the neural mechanisms underlying empathy disorders, and reviews recent advances in biomedical engineering for rehabilitation in connection with neurodevelopmental disorders and brain injuries. Lastly, the book discusses innovations in machine learning and artificial intelligence for computer-aided disease diagnosis and treatment, as well as applications of nanotechnology in therapeutic neurology.

These proceedings showcase the best papers selected from more than 500 submissions, and introduce readers to the latest research topics and developmental trends in the theory and application of MMESE. The integrated research topic Man-Machine-Environment System Engineering (MMESE) was first established in China by Professor Shengzhao Long in 1981, with direct support from one of the greatest modern Chinese scientists, Xuesen Qian. In a letter to Long from October 22nd, 1993, Qian wrote: "You have created a very important modern science and technology in China!" MMESE studies the optimum combination of man-machine-environment systems. In this system, "man" refers to the people in the workplace (e.g. operators, decision-makers); "machine" is the general name for any object controlled by man (including tools, machinery, computers, systems and technologies), and "environment" describes the specific working conditions under which man and machine interact (e.g. temperature, noise, vibration, hazardous gases, etc.). The three main goals of optimizing man-machine-environment systems are to ensure safety, efficiency and economy. These proceedings present interdisciplinary studies on concepts and methods from physiology, psychology, system engineering, computer science, environmental science, management, education, and other related disciplines. They offer a valuable resource for all researchers and professionals whose work involves interdisciplinary areas touching on MMESE subjects.

For two-semester anatomy & physiology lab courses. A concise, workbook-style approach for a fast-paced A&P lab course This full-color laboratory manual is designed for instructors who teach a two-semester anatomy & physiology lab course, but do not require the full range of laboratory exercises found in Marieb and Smith's best-selling Human Anatomy & Physiology Lab Manual (Cat, Fetal Pig, and Main). Written to complement Marieb and Hoehn's streamlined Anatomy & Physiology, 7th Edition, the manual can be used with any two-semester text. The 27 concise, activity-based lab exercises explore fundamental concepts in anatomy & physiology and build students' observational and laboratory skills. The manual's workbook-style approach incorporates visual summary tables, reviews key information, and engages students with hands-on drawing, labeling, and writing activities that can be completed using handy tear-out review sheets. Each lab includes learning objectives and efficient summaries of key concepts, as well as a list of materials needed for conducting the lab. The 7th Edition adds dozens of new, full-color illustrations and photos plus new critical thinking and clinical application questions to the Exercise Review Sheets. To improve clarity and readability, the headings, exercise tabs, and tables feature more saturated colors.

The Physiology of the Joints, conceived and written more than forty years ago by Dr. A. I. Kapandji, deals with biomechanics, a subject until then mentioned only incidentally in textbooks of anatomy. Following his lead, every anatomy textbook nowadays has a large component devoted to the functional aspect of the locomotor system, which has become an essential scientific subject. The seventh edition of this volume deals with the head and the spinal column and has been expanded with the inclusion of new diagrams and text dealing in particular with: The role of the femurs during the different stages of labour The concepts of mass, weight and barycentre How to localise the barycentres Joint hypermobility The law of parsimony and the law of universal profusion This book is intended for medical and physical therapy students; and for practising physicians and surgeons wishing to increase their knowledge of the functional anatomy of the locomotor system.

Information is central to the evolution of biological complexity, a physical system relying on a continuous supply of energy. Biology provides superb examples of the consequent Darwinian selection of mechanisms for efficient energy utilisation. Genetic information, underpinned by the Watson-Crick base-pairing rules is largely encoded by DNA, a molecule uniquely adapted to its roles in information storage and utilisation.This volume addresses two fundamental questions. Firstly, what properties of the molecule have enabled it to become the predominant genetic material in the biological world today and secondly, to what extent have the informational properties of the molecule contributed to the expansion of biological diversity and the stability of ecosystems. The author argues that bringing these two seemingly unrelated topics together enables Schroedinger's What is Life?, published before the structure of DNA was known, to be revisited and his ideas examined in the context of our current biological understanding.

The decline of infections, starvation, warfare, heart attack and stroke has allowed people to reach extreme old age but ushered in disability, dementia and degenerative disease, with profound consequences for the self and society. Dr Guy Brown explores these vital issues at various levels, from the cell, to the whole body, to society.

Encephalitis lethargica ('sleeping sickness') was a mysterious disorder that swept the world in the decade following the First World War, before disappearing without its cause having been identified. Around 85% of its victims, predominantly children, adolescents and younger adults, survived the acute disorder, but most developed severe neurological syndromes, particularly severe post-encephalitic parkinsonism and other severe motor abnormalities, that incapacitated them for the remainder of their lives. Despite its brief history, encephalitis lethargica played a major role in a variety medical discussions between the two World Wars, as this epitome of neuropsychiatric disease - attacking both motor and mental functions - appeared just as the separation of neurology and psychiatry had reached a critical point. Encephalitis lethargica sufferers presented an unprecedented combination of neurologic and psychiatric symptoms - including previously puzzling phenomena primarily associated with schizophrenia and hysteria, as well as behavioral changes and attention deficit disorders in children - that not only underscored the unity of mind and movement in the CNS, but also illuminated the critical role played by subcortical structures in consciousness and other higher mental functions that had formerly been associated with the soul and more recently presumed to be localized to the human cerebral cortex. Encephalitis lethargica exerted a greater influence on clinical and theoretic neuroscientific thought between the two World Wars than any other single disorder and had an enduring impact upon neurology and psychiatry. This book will be of interest to an educated audience active or interested in clinical (neurology, psychiatry, psychology) or laboratory neuroscience, particularly those interested in neuropsychiatry, as well as to those interested in the history of the biomedical sciences.

The book provides a reference for years to come, written by world-renowned expert investigators studying sex differences, the role of sex hormones, the systems biology of sex, and the genetic contribution of sex chromosomes to metabolic homeostasis and diseases. In this volume, leaders of the pharmaceutical industry present their views on sex-specific drug discovery. Many of the authors presented at the Keystone Symposium on "Sex and gender factors affecting metabolic homeostasis, diabetes and obesity" to be held in March 2017 in Lake Tahoe, CA. This book will generate new knowledge and ideas on the importance of gender biology and medicine from a molecular standpoint to the population level and to provide the methods to study them. It is intended to be a catalyst leading to gender-specific treatments of metabolic diseases. There are fundamental aspects of metabolic homeostasis that are regulated differently in males and females, and influence both the development of diabetes and obesity and the response to pharmacological intervention. Still, most preclinical researchers avoid studying female rodents due to the added complexity of research plans. The consequence is a generation of data that risks being relevant to only half of the population. This is a timely moment to publish a book on sex differences in diseases as NIH leadership has asked scientists to consider sex as a biological variable in preclinical research, to ensure that women get the same benefit of medical research as men.

The atlas of the Light and Specular Microscopy of the Cornea, particularly of the corneal endothelium presents photographs of healthy and pathological corneas, as well as corneas prepared for grafting. Photographs are taken from donor or patient's corneas. The first part section of the atlas shows healthy corneas and its particular layers: the epithelium (superficial and basal cells, subepithelial nerve plexus), stroma and keratocytes, and the endothelium. Blood vessels or palisades of Vogt in limbus are shown as well. The second part section that shows corneas processed for grafting is focused focuses on the endothelial layer. Main causes of exclusion of corneas from grafting, such as the presence of dead cells, polymeghatism, pleomorphism, cornea guttata or stromal scars have been shown. The third part section of the atlas shows corneas before and after storage in tissue cultures or hypothermic conditions with the aim to assess its suitability of for tissue for grafting. The last final section contains photographs of pathological corneal explants

The publication of "Vanadium: Biochemical and Molecular Biological Approaches" is particularly timely as it exactly coincides with the centennial anniversary of the discovery of vanadium by Professor Henze, in the blood cells of an ascidian (tunicate) collected in Gulf of Naples in 1911. Vanadium, atomic number 23, covers a wide range of oxidation states (from -2 to +5) and has unpaired electrons. Depending on these properties, a wide variety of enzymes and compounds containing vanadium have been found and the biochemical behaviour of vanadium has been investigated extensively.

This monograph provides not only the basic properties and recent advances of vanadium chemistry but also presents recent topics on hyper-accumulators of vanadium, enzymatic roles of vanadium, biochemical functions of vanadium and medicinal functions of vanadium, which have been discovered by Biochemical and Molecular Biological Approaches.

"Vanadium: Biochemical and Molecular Biological Approaches" is aimed at pure and applied chemists, biochemists, pharmaceutical and medical scientists.

This book provides an overview of microgravity-induced changes in human metabolism, muscle, bone and the cardio-vascular system, and discusses in detail the nutrient uptake required during spaceflight to counteract these adaptive mechanisms and ensure an improved physical constitution upon returning to Earth. It addresses the needs of professors, researchers and students working in the field of human physiology and nutrition.

This book presents cutting edge methods that provide insights into the pathways by which salt and water traverse cell membranes and flow in an orchestrated fashion amongst the many compartments of the body. It focuses on a number of molecular, cellular and whole animal studies that involve multiple physiological systems and shows how the internal milieu is regulated by multifactorial gene regulation, molecular signaling, and cell and organ architecture. Topics covered include: water channels, the urinary concentrating mechanism, angiotensin, the endothelin system, miRNAs and MicroRNA in osmoregulation, desert-adapted mammals, the giraffe kidney, mosquito Malpighian tubules, and circadian rhythms. The book highlights how different approaches to explaining the same physiological processes greatly increase our understanding of these fundamental processes. Greater integration of comparative, evolutionary and genetic animal models in basic science and medical science will improve our overall grasp of the mechanisms of sodium and water balance.

Leading researchers are specially invited to provide a complete understanding of the key topics in these archetypal multidisciplinary fields. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.

This book provides visionary perspective and interpretation regarding the role of wearable and wireless systems for the domain of gait and reflex response quantification. These observations are brought together in their application to smartphones and other portable media devices to quantify gait and reflex response in the context of machine learning for diagnostic classification and integration with the Internet of things and cloud computing. The perspective of this book is from the first-in-the-world application of these devices, as in smartphones, for quantifying gait and reflex response, to the current state of the art. Dr. LeMoyne has published multiple groundbreaking applications using smartphones and portable media devices to quantify gait and reflex response.

A&P may be complicated, but learning it doesn't have to be! Anatomy & Physiology, 11th Edition uses a clear, easy-to-read approach to tell the story of the human body's structure and function. Color-coded illustrations, case studies, and Clear View of the Human Body transparencies help you see the "Big Picture" of A&P. To jump-start learning, each unit begins by reviewing what you have already learned and previewing what you are about to learn. Short chapters simplify concepts with bite-size chunks of information. Conversational, storytelling writing style breaks down information into brief chapters and chunks of information, making it easier to understand concepts. 1,400 full-color photographs and drawings bring difficult A&P concepts to life and illustrate the most current scientific knowledge. UNIQUE! Clear View of the Human Body transparencies allow you to peel back the layers of the body, with a 22-page, full-color insert showing the male and female human body along several planes. The Big Picture and Cycle of Life sections in each chapter help you comprehend the interrelation of body systems and how the structure and function of these change in relation to age and development. Interesting sidebars include boxed features such as Language of Science and Language of Medicine, Mechanisms of Disease, Health Matters, Diagnostic Study, FYI, Sport and Fitness, and Career Choices. Learning features include outlines, key terms, and study hints at the start of each chapter. Chapter summaries, review questions, and critical thinking questions help you consolidate learning after reading each chapter. Quick Check questions in each chapter reinforce learning by prompting you to review what you have just read. UNIQUE! Comprehensive glossary includes more terms than in similar textbooks, each with an easy pronunciation guide and simplified translation of word parts - essential features for learning to use scientific and medical terminology! NEW! Updated content reflects more accurately the diverse spectrum of humanity. NEW! Updated chapters include Homeostasis, Central Nervous System, Lymphatic System, Endocrine Regulation, Endocrine Glands, and Blood Vessels. NEW! Additional and updated Connect It! articles on the Evolve website, called out in the text, help to illustrate, clarify, and apply concepts. NEW! Seven guided 3-D learning modules are included for Anatomy & Physiology.

This book provides an overview of recent advances in the study of aging and aging related diseases, discussing the topics at individual, organ, tissue, cell, and molecular levels. It also presents studies on the biomarkers of aging and anti-aging interventions. Aging has been becoming a global health problem. However it was not possible to determine aging as we usually diagnose a disease because there are few biomarkers for age estimation. Since ancient times, people have been seeking anti-aging substances and methods for achieving immortality, while the scientific study of aging has only existed for 100 years. This book appeals to researchers both in institutes and in pharmaceutical companies interested in further studies in this field.

These chapters analyze texts from Isaac Newton's work to shed new light on scientific understanding at his time. Newton used the concept of "sensorium" in writings intended for a public audience, in relation to both humans and God, but even today there is no consensus about the meaning of his term. The literal definition of the Latin term 'sensorium', or its English equivalent 'sensory', is 'thing that feels' but this is a theoretical construct. The book takes readers on a process of discovery, through inquiry into both Newton's concept and its underlying model. It begins with the human sensorium. This part of his concept is situated in the context of the aforesaid writings but also in the context of the writings of two of Newton's contemporaries, the physicians William Briggs and Thomas Willis, both of whom were at the forefront of their respective specialties of ophthalmology and neurology. Only once the human sensorium has been explored is it possible to generalize to the unobservable divine sensorium, because Newton's method of reasoning from experience requires that the second part of his concept is last in the order of knowledge. And the reason for this sequence is that his method, the short-hand term for which is 'analogy of nature', proceeds from that which has been observed to be universally true to that which is beyond the limits of observation. Consequently, generalization passes insensibly into reasoning by analogy. Readers will see how certain widespread assumptions can be called into question, such as that Newton was a theological voluntarist for whom the will is superior to the intellect, or that, for Newton, not only the world or universe but also God occupies the whole extent of infinite space. The insights afforded through this book will appeal to scholars of the philosophy of science, human physiology, philosophy of mind and epistemology, among others.

Atrial Fibrillation from an Engineering Perspective provides an up-to-date overview of techniques developed for acquisition, modeling, and analysis of noninvasive, bioelectrical signals reflecting this common arrhythmia. Special emphasis is put on emerging technologies for monitoring of atrial fibrillation in connection with ischemic stroke, interventional ablation procedures, and pharmacological treatment, applications which all depend on the availability of techniques for detecting and characterizing episodes of paroxysmal atrial fibrillation. Detectors exploring both rhythm and morphology are described, as well as detectors confined to rhythm and better suited for low power implementation. A wide variety of approaches to modeling and characterization of atrial activity are described, emanating from a statistical and deterministic starting points. This book is suitable for graduate students, researchers, and engineers who want a comprehensive treatise of atrial fibrillation from an engineering perspective. It may be used for self-study, as a supplement to courses in signal processing, or as a modern monograph by researchers in the field of atrial fibrillation.

This book offers one of the most comprehensive reviews in the field of gastrointestinal (GI) physiology, guiding readers on a journey through the complete digestive tract, while also highlighting related organs and glandular systems. It is not solely limited to organ system physiology, and related disciplines like anatomy and histology, but also examines the molecular and cellular processes that keep the digestive system running. As such, the book provides extensive information on the molecular, cellular, tissue, organ, and system levels of functions in the GI system. Chapters on the roles of the gut as an endocrine, exocrine and neural organ, as well as its microbiome functions, broaden readers' understanding of the multi-organ networks in the human body. To help illustrate the interconnections between the physiological concepts, principles and clinical presentations, it outlines clinical examples such as pathologies that link basic science with clinical practice in special "clinical correlates" sections. Covering both traditional and contemporary topics, it is a valuable resource for biomedical students, as well as healthcare and scientific professionals.

This textbook presents for the first time a comprehensive body of the latest knowledge in the field of neuropeptides and their action on energy balance. It contains a detailed and comprehensive account of the specific hypothalamic peptides in regards to their roles in energy balance, food intake control and co-morbidities, to better understand the patho-physiology of obesity. The textbook includes an examination the history of the evolution of human society from a thin to the obese phenotype and, within that context, how modern society habits and industrial food production did not respect the evolutionary trait resulting in changes in the energy balance set point. It provides a novel conceptualization of the problem of obesity when considering the biochemistry of peptide hormones and entertaining novel ideas on multiple approaches to the problems of energy balance, as well as demonstrates and explains why alterations in pro-hormone processing are paramount to understand metabolic disease. This text is excellent material for teaching graduate and medical school courses, as well as a valuable resource for researchers in biochemistry, cell, and molecular biology, neuroscientists, physician endocrinologists, and nutritionists.