An analysis of cell death in reproductive physiology. It examines topics such as the control of apoptosis in the uterus during decidualization and stern cell factor regulation of apoptosis in mouse primordial germ cells.

Written by nearly 60 of the world's leading investigators in this rapidly expanding field, this state-of-the-art reference furnishes detailed presentations on the basic science and clinical aspects of cilia, mucus, and mucociliary interactions. Providing stimulating coverage of the latest information in a single source, Cilia, Mucus, and Mucociliary Interactions -discusses the genetic determinants of mucociliary system structure and function -explains ciliary wave activity in cell-cell communication -elucidates many of the key physiological processes in ciliary regulation -reveals possible means of treating irregularities in mucus secretion and clearance -improves understanding of clinical syndromes, including abnormalities pertaining to nasal sinuses, upper and lower airways, and the systemic role of cilia -approaches the clinical management of mucociliary dysfunction logically using currently available diagnostic and therapeutic techniques -and much more! Containing bibliographic citations, tables, equations, drawings, and photographs, this exhaustive guide is essential reading for physiologists, pulmonologists, otolaryngologists, pediatricians, microbiologists, basic scientists, and graduate and medical school students in these disciplines.

This volume is a compendium of knowledge relating to the biology, pathophysiology, pharmacology, and genetics of lipoxygenases and their products, edited as proceedings of an International Congress held in Malta in the summer of 1997. The aim of the book is to broaden the existing knowledge on lipoxygenases and metabolites and to identify directions for future research. Papers based on the Congress lectures are gathered together here under three general headings: enzymology, molecular biology and biological functions of mammalian lipoxygenases; metabolic regulation of lipoxygenases and lipoxygenase inhibitors; and products of the lipoxygenase pathways and their receptors, which present forward-looking presentations.

Bone is a complex biological material that consists of both an inorganic and organic phase, which undergoes continuous dynamic biological processes within the body. This complex structure and the need to acquire accurate data have resulted in a wide variety of methods applied in the physical analysis of bone in vivo and in vitro. Each method has its own strengths and applications depending on the information sought by the clinician or researcher. The Physical Measurement of Bone provides a detailed description of all the major methods of bone analysis, including brief comments on clinical evaluation. The physics of each method are introduced as well as a summary of practical procedures. The book is essential reading for practicing medical physicists and technicians who need to know about the many methods of bone analysis open to them, and, more importantly, the wide coverage provides a good introductory framework for students of medical physics and biomedical engineering.

Originally published in 1990, Nobel Laureates in Medicine or Physiology is a biographical reference work about the recipients of Nobel Prizes in Medicine or Physiology from 1901-1989. Each article is written by an accomplished historian of medicine or science. The book is designed to be accessible to students and general readers as well as to specialists in medical science and history. Each article combines personal and scientific biography, and each has an extensive biography to guide further reading and research.

A state-of-the-art summary from leading laboratories around the world of our current knowledge of the molecular biology, the physiology, and the pharmacology of the P2 receptors. The authoritative contributions cover the major aspects of these receptors, describing the relationships between physiological and pharmacological effects of ATP and other nucleotides and the various cloned P2 receptors, as well as providing an historical perspective and discussing current issues of nomenclature. They also illuminate how P2 receptor structures contribute to their function, including the physical differences underlying the pharmacological and functional variations among P2 receptor subtypes.

This book explores several subtypes of muscarinic receptors that modulate smooth muscle activity. Main topics include a classification of muscarinic receptors, biochemical responses that occur in smooth muscle, the role of muscarinic receptors in the function of gastrointestinal and genitourinary smooth muscle, and prejunctional muscarinic receptors in smooth muscle. Discussions cover the current state of research and are intended to generate further research into the design of novel therapeutics for disorders of smooth muscle function.

Instant Notes in Human Physiology will be valuable to students in whatever context they are studying physiology. It explains fundamental concepts and the major physiological systems, showing how they are integrated, without overloading the reader with information. key selling features: Explains physiology in the light of advances in molecular biology and cellular biology. Shows how the major physiological systems are integrated. Approaches physiology from the view that the purpose of life is to reproduce.

This book covers key topics in polyamine research from a range of organisms, including plants, mammals, and prokaryotes such as bacteria and archaea. The book provides an introduction to general concepts in the field of polyamine research, as well as more detailed information. With the availability of genome sequence data from a broad range of organisms, the evolution of the genes involved in polyamine metabolism is discussed. The mode of action of polyamines has been shown to be dependent on cation channels, and this mechanism is described in the book. The origin of polyamine transporters (from bacteria, yeasts, and plants) is described. The various effects of polyamines on growth and survival are also documented. The book details the mechanisms of polyamine homeostasis and the role of polyamine molecules as precursors of secondary metabolites such as plant alkaloids and toxins derived from spiders and wasps. The role of polyamines in longevity and disease is discussed. A link between polyamine contents and cancer progression is reported, as is the use of polyamine metabolites as diagnostic markers in the initial stages of cancer. Moreover, a novel approach that utilizes the polyamine pathway of a parasite as a drug target in African sleeping sickness is described. Therefore, this book is a valuable resource, both as a textbook for undergraduate and graduate students and also as a reference book for front-line polyamine researchers.

This volume is based on presentations by the world-renowned investigators who gathered at the 74th annual Cold Spring Harbor Symposium on Quantitative Biology to celebrate the 150th anniversary of the publication of Charles Darwin's On the Origin of Species. It reviews the latest advances in research into evolution, focusing on the molecular bases for evolutionary change. The topics covered include the appearance of the first genetic material, the origins of cellular life, evolution and development, selection and adaptation, and genome evolution. Human origins, cognition, and cultural evolution are also covered, along with social interactions. The line-up of speakers comprised a stellar list of preeminent scientists and thinkers such as the zoologist and prolific author E. O. Wilson (Harvard University); Jack W. Szostak (Harvard Medical School), a 2009 Nobel Prize winner who studies the chemistry of life's origins; and Nobel Prize winner and former president of HHMI Thomas Cech (Colorado Institute for Molecular Biotechnology), to name just a few.

These proceedings showcase the best papers selected from more than 500 submissions, and introduce readers to the latest research topics and developmental trends in the theory and application of MMESE. The integrated research topic Man-Machine-Environment System Engineering (MMESE) was first established in China by Professor Shengzhao Long in 1981, with direct support from one of the greatest modern Chinese scientists, Xuesen Qian. In a letter to Long from October 22nd, 1993, Qian wrote: "You have created a very important modern science and technology in China!" MMESE studies the optimum combination of man-machine-environment systems. In this system, "man" refers to the people in the workplace (e.g. operators, decision-makers); "machine" is the general name for any object controlled by man (including tools, machinery, computers, systems and technologies), and "environment" describes the specific working conditions under which man and machine interact (e.g. temperature, noise, vibration, hazardous gases, etc.). The three main goals of optimizing man-machine-environment systems are to ensure safety, efficiency and economy. These proceedings present interdisciplinary studies on concepts and methods from physiology, psychology, system engineering, computer science, environmental science, management, education, and other related disciplines. They offer a valuable resource for all researchers and professionals whose work involves interdisciplinary areas touching on MMESE subjects.

This volume provides a thorough overview of current knowledge of stress proteins in both normal and disease physiology. It draws upon current stress protein research to evaluate the potential for developing new diagnostic, prophylactic and therapeutic approaches to control human disease.

Nutrition and Health: Topics and Controversies explores in detail the relationship between diet, nutritional status, and disease, and evaluates nutritional practices intended to minimize the incidence of and slow the progress of major chronic illnesses. National trends in nutritional awareness and the resulting changes in consumer behavior are discussed. Unlike other books on this subject, the authors take a stand on controversial issues in the field and document their positions with scientific data. Nutrients such as calcium, vitamin E, selenium, and antioxidants, their importance in overall nutrition, and their role in specific diseases are covered. Expertise in nutritional science is not required to gain the highly practical information in this book.

Although work furniture has had so much more attention recently there is a long way to go before this is translated into action in the wider world. Increased international concern for the health and safety of people at work is one of the driving forces behind this book.; The Science of Seating brings together researchers in ergonomics and posture with industrial designers, to review and assess the current state of chair design, with implications for cultural, behavioural and occupational aspects of health. The contributions are a significant step in the science of seating and should lead to a better understanding of the mechanics, dynamics and the effects of seating on the sitter.; They point to ways in which seats might become easier-to-use and adjust, offering both comfort and postural support without compromising freedom of movement: and in the not-too-distant furture, "the intelligent chair" will "remember" the sitter's preferences for position, cushiness and so on.; Topics covered include: Adjustability, Anthropometics, Posture, Back Pain, Biomechanics, Seat Pressure Distributions, School children, Special Needs of Users, Design Applications, Industry Perspectives, VDT Standards.; It is aimed at researchers and practising seating designers, ergonomists, design engineers, occupational health workers and physiotherapists and furniture manufacturers.

Sport, Recovery and Performance is a unique multi-disciplinary collection which examines both the psychological and physiological dimensions to recovery from sport. Including contributions from medicine, neuroscience, psychology and sport science, the book expertly explores the implications for applied and strategic interventions to both retain and stabilize performance, and promote health and well-being. Including chapters written by its leading experts, the book represents an important milestone in this evolving field of study. It covers issues around measuring recovery, the impact of overtraining on sleep and mental health, and addresses topics such as the impact of travel on performance. The book informs not only how managing recovery can improve performance, but also offers insights in how recovery can sustain athletes' physical and mental health. Citing research from a range of individual and team sports, as well as extreme situations and the workplace, this is an important book that will be widely read across the sport sciences.

The series CNS Neurotransmitters and Neuromodulators is destined to be the definitive reference work on the physiology and pharmacology of the central nervous system. Written by an outstanding group of international authors, chapters cover a wide range of interdisciplinary aspects of the subject.
This first volume includes an in-depth examination of acetylcholine, ranging from the localization of synthetic enzymes through electrophysiology, pharmacology, and molecular biology to behavioral importance in learning and memory. This indispensable and comprehensive reference keeps you abreast of new developments in several areas of neuroscience.

Audience
Applied biomathematicians, orthopedists, clinical orthopedists.

Introduction to Computational Cardiology provides a comprehensive, in-depth treatment of the fundamental concepts and research challenges involved in the mathematical modeling and computer simulation of dynamical processes in the heart, under normal and pathological conditions.

About this textbook:

- Presents descriptions of models used in both biology and medicine for discovering the mechanisms of heart function and dysfunction on several physiological scales across different species.

- Provides several examples throughout the textbook and exercises at the end which facilitate understanding of basic concepts and introduces, for implementation, treated problems to parallel supercomputers.

Introduction to Computational Cardiology serves as a secondary textbook or reference book for advanced-level students in computer science, electrical engineering, biomedical engineering, and cardiac electrophysiology. It is also suitable for researchers employing mathematical modeling and computer simulations of biomedical problems.

Whether you're a clinician concerned with patient management, a technician involved in diagnostic testing, or an investigator studying fibrinogen structure and function, you'll find that the 1994 Index of Variant Human Fibrinogens. is a valuable resource. It contains not only the most comprehensive compilation of the world literature and research on dyfibrinogenemia, but also includes a synopsis for health professionals and expert guidance for the diagnosis and treatment of dysfibrinogenemia, the study of genetically abnormal human fibrinogens. Furthermore, this book provides the latest DNA and protein sequences (including the AaE chain) and listings of available PCR primers and anti-fibrinogen antibodies. Add to this a set of 263 Dysfibrinogen Reports tracking more than 30 different characteristics for each variant, plus 9 summary tables and a comprehensive bibliography, and the result is an authoritative companion for the diagnosis and management of this multifaceted and complex disease.
Compare your patient's laboratory profile, clinical manifestations, or molecular defect with virtually all others in the literature. Consider all the options for treating bleeding or thrombotic complications. Determine if your data from a newly identified variant are unique. Spend an hour with this book and see if it doesn't save many hours of literature searching and summarizing

How do you learn A&P best? Whatever your learning style...by reading, listening, or doing, or a little bit of each...the 3rd Edition of this new approach to anatomy & physiology is designed just for you. Tackle a tough subject in bite-sized pieces. A seemingly huge volume of information is organized into manageable sections to make complex concepts easy to understand and remember. You begin with an overview of the body, including its chemical and cellular structures, then progress to one-of-a-kind portrayals of each body system, grouped by function. Full-color illustrations, figures, sidebars, helpful hints, and easy-to-read descriptions make information crystal clear. Each unique page spread provides an entire unit of understanding, breaking down complex concepts into easy-to-grasp sections for today's learner. "Fast Facts" in each chapter contain interesting tips related to the system. "The Body at Work" addresses physiology of the system under discussion. "Life Lessons" apply A&P information to real-life situations. "Own the Information" exercises ask students to identify the most important points in each chapter and compare them to the learning objectives. Instructor resources: Ebook, testing resources, classroom & lecture planning resources, previous edition resources. Includes webinar recording, rollover guide to the book, questions & scenarios, PowerPoint slides, image banks, testbank Student resources: Interactive resources, flash cards, animations, podcast library, reference resources, audio glossary, PowerPoint slides

This reference work brings together the biology, mechanics, neurophysiology and pathophysiology of diseased joints, illustrates available physiologically-based treatments for osteoarthrosis and explains how and when to use them.;Highlighting the most up-to-date biomechanical principles, Mechanics of Human Joints: discusses the functional anatomy of joints; relates the neurophysiology of joints to ligamentous reconstruction; elucidates the pathophysiology of osteoarthrosis; summarizes the latest information on muscle physiology and electromyography; examines the effect of vibration and impulsive loading on joint pathology; and explicates the principles of prosthetic joint replacement.

Notes On Clinical Biochemistry shows how the details of molecular architecture and metabolic pathways which every biochemistry student has to learn can be summarised and made applicable to a wide range of clinical problems. This is done partly by a theoretical discussion of the links between the basic biochemistry and corresponding medical scenarios, and partly by the discussion of case histories. In this way, a very wide range of medical problems is discussed economically.This book is aimed at all those studying clinical chemistry, and medical students in the middle period of their course, that is the 2nd - 4th years. This is when the knowledge of basic sciences gained in the earlier period comes to be applied to clinical situations, and the book attempts to show, with respect to biochemistry, how this continuum is achieved.

The quality of life for millions of people all over the globe has been improved by the work of diligent biologists and doctors working in the many branches of life science. An improved knowledge of how the body functions at the genetic, cellular, physiological and behavioural levels and a greater understanding of disease and pharmacology have resulted in a reduction in human suffering. The way is being paved for the effective treatment of some of the greatest health problems of the late twentieth century - cancer, AIDS and diseases caused by parasites.These two volumes are collections of the Nobel Lectures delivered by the laureates, together with their biographies, portraits and the presentation speeches for the periods 1971 - 1980 and 1981 - 1990 respectively. Each Nobel Lecture is based on the work for which the laureate was awarded the prize. New biographical data of the laureate are also included. These volumes of inspiring lectures by outstanding scientists should be on the bookshelf of every keen student, teacher and professor of biological and medical sciences as well as of those in related fields.During the period 1971 - 1980 important areas of research being recognized were as diverse as hormone action and radioimmunoassays, infectious diseases, molecular genetics, immunology, computerized tomography and social behaviour. The laureates according to the specific year are:(1971) E W SUTHERLAND JR - for his discoveries concerning the mechanisms of the action of hormones; (1972) G M EDELMAN & R R PORTER - for their discoveries concerning the chemical structure of antibodies; (1973) K VON FRISCH, K LORENZ & N TINBERGEN - for their discoveries concerning organization and elicitation of individual and social behaviour patterns; (1974) A CLAUDE, C DE DUVE & G E PALADE - for their discoveries concerning the structural and functional organization of the cell; (1975) D BALTIMORE, R DULBECCO & H M TEMIN - for their discoveries concerning the interaction between tumour viruses and genetic material of the cell; (1976) B S BLUMBERG & D C GAJDUSEK - for their discoveries concerning new mechanisms for the origin and dissemination of infectious diseases; (1977) R GUILLEMIN & A V SCHALLY - for their discoveries concerning the peptide hormone production of the brain; and R S YALOW - for the development of radioimmunoassays of peptide hormones; (1978) W ARBER, D NATHANS & H O SMITH - for the discovery of restriction enzymes and their application to problems of molecular genetics; (1979) A M CORMACK & G N HOUNSFIELD - for the development of computer assisted tomography; (1980) B BENACERRAF, J DAUSSET & G D SNELL - for their discoveries concerning genetically determined structures on the cell surface that regulate immunological reactions.

Zika Virus Biology, Transmission, and Pathways: The Neuroscience of Zika, Volume One provides a detailed introduction to the molecular biology of the Zika virus and its features, transmission, and impact on neurological systems. Designed to better readers' understanding of the Zika virus, this volume features chapters on the immune response, molecular mechanisms, and other areas to better understand underlying pathways. This book has applicability for neuroscientists, neurologists, virologists and anyone working to better understand the evolution and pathogenesis of Zika virus-related conditions.

Many hereditary cancer syndromes are linked to alterations in single genes. Detection and clinical interpretation of these alterations can guide cancer risk reduction for patients and their families through screening, prophylactic measures, and other strategies. Diagnosis and Management of Hereditary Cancer summarizes hereditary syndromes and their associated cancers and genes. The information is presented in 50 practice-enhancing tables that relate clinical, genetic, diagnostic, and management aspects in a manner that has previously not been available in a single reference. Intended to guide the specialist as well the novice, this volume will elevate the care of hereditary cancer patients and their families.