This important issue of Endocrinology Clinics is devoted to the unique topic of endocrine-adrenal and steroid hypertension. The following topics are covered. An overview of endocrine systems and hypertension; accuracy and cost effectiveness of screening for adrenal-endocrine hypertension; pheochromocytoma and related chromaffin cell tumors in adreno-medullary disease; variants, detection, and treatment of Cushing's Syndrome; how glucocorticoids cause hypertension and cardiovascular disease; primary aldosteronism, Conn's diagnosis and management; familial or genetic primary aldosteronism in Gordon's Sydrome; Liddle's Syndrome, Bartter, Gitelman, and related disorders of high and low pressure and pregnancy-related hypertension due to MR mutation; glucocorticoid remediable hypertension; low rennin hypertension in childhood; ovarian hypertension and PCOS; and oral contraceptives and hypertension.

Endocrine imaging is covered extensively in this issue of Radiologic Clinics. Articles will include: Thyroid Ultrasound, Part 1: Technique and Diffuse Disease; Thyroid Ultrasonography, Part 2: Nodules; Thyroid: Nuclear Medicine Update; Thyroid Cytology: Challenges in the Pursuit of Low-Grade Malignancies; Diagnosis and Treatment of Differentiated Thyroid Carcinoma; Thyroid Carcinoma: The Surgeon's Perspective; Imaging Surveillance of Differentiated Thyroid Cancer; Parathyroid Imaging; Adrenal Imaging: From Addison to Algorithms; Imaging of Neuroendocrine Tumors; Imaging of the Pituitary, and more!

This two-part issue of Endocrinology and Metabolism Clinics of North America provides the endocrinologist with comprehensive essential updates about tumors of the gastroenteropancreatic system. Topics covered include the history and development of the gastroenteropancreatic endocrine axis; the changing face and epidemiology of neuroendocrine tumors (NETs); chromogranins current state of the art, pathology of gastroenteropancreatic (GEP) disorders; new and emerging syndromes related to gastrointestinal (GI) hormones; an update on incretins; prospects for ghrelin in the clinic, obesity/appetite and hedonism; GI motility disorders; gastric bypass and GI hormones; pancreatic exocrine function and GI hormones; harnessing the pancreatic stem cell; how to diagnose NETs before there are METs; NETs in kids: combining the SEER data for children and adults with site differences; novel biomarkers for NETs; standard imaging techniques for NETs; novel peptide imaging: glucagon receptor; signaling mechanism in NETs as targets for therapy; update on clinical trials; nutrition and the GEP; peptide radiotherapy; in vitro analysis of NETs: the role of angiogenesis; modern lab evaluation of peptide and amines: a continuing role for radioimmunoassay?; surgery/surgical management of NETs; and evaluation and quality of life in NETs patients.

This two-part issue of Endocrinology and Metabolism Clinics of North America provides the endocrinologist with comprehensive essential updates about tumors of the gastroenteropancreatic system.? Topics covered include the history and development of the gastroenteropancreatic endocrine axis; the changing face and epidemiology of neuroendocrine tumors (NETs); chromogranins current state of the art, pathology of gastroenteropancreatic (GEP) disorders; new and emerging syndromes related to gastrointestinal (GI) hormones; an update on incretins; prospects for ghrelin in the clinic, obesity/appetite and hedonism; GI motility disorders; gastric bypass and GI hormones; pancreatic exocrine function and GI hormones; harnessing the pancreatic stem cell; how to diagnose NETs before there are METs; NETs in kids: combining the SEER data for children and adults with site differences; novel biomarkers for NETs; standard imaging techniques for NETs; novel peptide imaging: glucagon receptor; signaling mechanism in NETs as targets for therapy; update on clinical trials; nutrition and the GEP; peptide radiotherapy; in vitro analysis of NETs: the role of angiogenesis; modern lab evaluation of peptide and amines: a continuing role for radioimmunoassay?; surgery/surgical management of NETs; and evaluation and quality of life in NETs patients.

This comprehensive issue of the Rheumatic Disease Clinics of North America provides the latest information on the intersection between endocrinology and rheumatology, and explores rheumatologic manifestations of endocrine disease.? Topics covered include thyroid disease (hyperthyroid, hypothyroid, chronic autoimmune thyroiditis, and thyroid disorders in patients with connective tissue diseases such as RA, Sj?gren's Syndrome, scleroderma, juvenile RA, and hemochromatosis); parathyroid disease (hyperparathyroid, hypoparathyroid, rheumatic complaints associated with metabolic bone disease such as osteoporosis, osteomalacia, and renal osteodystrophy); diabetes mellitus (rheumatic manifestations of metabolic syndrome, diffuse idiopathic hyperostosis, carpal tunnel syndrome, adhesive capsulitis, flexor tenosynovitis, and Dupuytren's contracture); adrenal disorders (Addison's Disease and Cushing's Syndrome); disorders of the pituitary gland (acomegaly and hypothalamic-gonadal axis); and pregnancy.

From Ernest L. Mazzaferri, MD MACP: ." . . experts in their respective areas, provide succinct editorial comments with references for each article, which the practicing physician will find useful in day-to-day practice." There's no faster or easier way to stay informed! The Year Book of Endocrinology brings you abstracts of the articles that reported the year's breakthrough developments in endocrinology carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice.

This issue features internationally renowned experts who have provided their expertise on a variety of topics related to the importance of vitamin D. It was not until feedback loops were identified between vitamin D production and parathyroid hormone, phosphate that it earned its place as a true endocrine hormone. Current social and economic conditions have brought it back into the limelight with outbreaks of rickets and osteomalacia even in developed countries. However its complex regulation, together with the identification and characterization of the vitamin D receptor and its role in influencing multiple genetic pathways and function has heralded a new era highlighting its importance in health and disease. This includes its role in autoimmune diseases such as multiple sclerosis, diabetes mellitus, cancer especially breast and prostate, skin, neurological and cognitive disorders, and infectious diseases such as tuberculosis. We now know that adequate levels of vitamin D it is important in preventing falls and fracture. The need for supplementation and the amount recommended has also changed considerably from what we previously considered sufficient. The ongoing development of selective active analogs of vitamin D targeted to specific organs and function leads to the exciting possibility of improving outcomes of diseases associated with vitamin D regulation.

Neuroendocrinology is a discipline which originated about 50 years ago as a branch of Endocrinology and that is now strictly linked to neuroscience.

Volumes 181 and 182 of Progress in Brain Researchprovide a rapid view of the major points presently discussed at biological and clinical levels.

The chapters have been written by top scientists who are directly involved in basic or clinical research and who use the most sophisticated biotechnological techniques.

The volumes cover of the role of genetics in many endocrine-related events, like neuroendocrinological diseases and endocrine depenedent cancers (prostate, breast, etc, ). Interesting information is also provided on possibile treatments of neurodegenerative brain diseases (e.g., Alzheimer and similar syndromes).

The best researchers in the field provide their conclusions in the context of the latest experimental results

Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered

Of great value for researchers and experts, but also for students as a background reference"

Apart from diabetes mellitus, endocrine diseases requiring surgical treatment are relatively uncommon. However, when they do occur, they frequently present major clinical anaesthestic problems that require extensive knowledge of the pathophysiology of the condition, and considerable anaesthetic expertise. This book provides the anaesthetist with a comprehensive examination of each of the endocrine conditions, covering underlying pathophysiological problems, and guidance on optimal anaesthetic care. It will be of use to trainee and consultant anaesthetists working in both specialist endocrine wards and general surgery wards where a patient with endocrine disease might present.

Neuroendocrinology is a discipline which originated about 50 years ago as a branch of Endocrinology and that is now strictly linked to neuroscience.

Volumes 181 and 182 of Progress in Brain Researchprovide a rapid view of the major points presently discussed at biological and clinical levels.

The chapters have been written by top scientists who are directly involved in basic or clinical research and who use the most sophisticated biotechnological techniques.

The volumes cover of the role of genetics in many endocrine-related events, like neuroendocrinological diseases and endocrine depenedent cancers (prostate, breast, etc, ). Interesting information is also provided on possibile treatments of neurodegenerative brain diseases (e.g., Alzheimer and similar syndromes).

The best researchers in the field provide their conclusions in the context of the latest experimental results

Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered

Of great value for researchers and experts, but also for students as a background reference"

Proposed topics for this issue include: Molecular markers in thyroid neoplasms; Surgical management of primary hyperparathyroidism; Surgical management of well-differentiated thyroid cancer; Surgical management of carcinoid tumors; Recurrent laryngeal nerve monitoring; Surgical management of Zollinger-Ellison syndrome; Management of adrenal cancer; Sporadic and familial medullary thyroid cancer; Insulinoma; Adrenal incidentaloma; Secondary and tertiary hyperparathyroidism; Aldosteronomas; Surgical Management of MEN 1, and 2; Surgical Management of non-M.E.N. endocrinopathies.

Developed by a renowned group of international authors, this engaging, case-based title once again offers readers a wide range of thought-provoking case studies that reflect contemporary, challenging, hands-on clinical care. Expanded and fully updated, Endocrinology and Diabetes: A Problem Oriented Approach, 2nd Edition addresses the complete range of endocrinologic problems found in patient care, offering the reader a convenient and pointed way to solve clinical problems in a timely manner. Due to its comprehensive coverage and practical focus, this title has developed a special place in the field of endocrinology and will again be of great interest to endocrinologists, diabetologists, internal medicine physicians, family physicians, fellows, and residents. The enthusiastic reception and warm welcome of the first edition of this book was overwhelming and gratifying. Despite many standard texts that cover physiology and clinical aspects of endocrinology, this book found a special place because it focused on patient care and practical aspects of endocrine practice. In the current volume we were fortunate to again have the honor of collaboration by international authors who pride themselves foremost as clinical endocrinologists. We hope our readers will find this updated, improved edition worthwhile, and use it for the benefit of their patients.

This two-part issue of the Endocrinology and Metabolism Clinics of North America brings the practicing endocrinologist up to date on the most important topics in pediatric endocrinology. Part I covers genomics: genetic disorders and new techniques; newborn screening; hormones in the premature infant; congenital disorders of the thyroid: hyper/hypo; glucose in the PIC setting; diabetes prevention; obesity: etiology, prevention, and treatment; metabolic syndrome in pediatrics; complementary and alternative medicine in pediatric endocrinology; imaging in pediatric endocrine dosoirders; U/S gonads; and global epidemiology of Type 1 diabetes.

This issue of the Endocrinology and Metabolism Clinics of North America, devoted to the topic of lipids, provides the most essential updates and new treatments in the field. The following subject matter is addressed: assessment of the effectiveness of advanced lipoprotein testing; rosk scores for prediction of cardiovascular outcomes; lifestyle and dietary approaches to lowering LDC-cholesterol and triglycerides, and raising HDL-cholesterol; comparative efficacy and safety of statins, ezetimibe, bile acide binders, and combinations for lowering LDL-C; alternative therapies for reducing LDL-C, including intestinal bypass, and new medications such as squalene synthase inhibitors, ApoB antisense oligonucleotides, small interfering RNA's of Apo B and proprotein convertase subtilism kexin 9 (PCSK9); myopathic problems of statins; pharmacologic management of hypertriglyceridemia, including fibric acids, niacin, and fish oils; new treatments for raising LDL cholesterol, lipid management in special patient populations, including pediatric, geriatric, and patients with HIV; lipid management in renal failure, hemodialysis, and transplantation.

Autoimmune disorders are amongst the most frequently encountered conditions in endocrine practice. The evidence-based approach to therapeutics and detailed evaluation of the outcome of existing treatment regimens have led to some advances in care delivery. Pragmatic reviews by leading international experts outline the clinical state of the art in several chapters of this issue of the Endocrinology and Metabolism Clinics of North America devoted to autoimmune disorders. Topics covered include the following: regulatory T cells as key players in tolerance and autoimmunity; immunology lessons from monogenic conditions such as AIRE; immunogenetics of T1D and AITD; advances in T1D therapeutics, including islet cell replacement and salvage; updates on TSHR structure, function, and monoclonal human TSHR antibodies; animal models of Grave's disease; evidence-based and emerging modalities of treatment of Graves' hyperthyroidism; patient selection and treatment of thyroid-associated ophthalmopathy; antibodies to steroidogenic tissues: Addison's and POF; diagnosis and management of polyendocrinopathy syndromes; autoimmune parathyroid disease; and autoimmune hypophysitis.

This comprehensive book on Endocrine Surgery covers disorders of thyroid, parathyroid, adrenal glands along with neuroendocrine tumors of pancreas and gastrointestinal tract. It is a comprehensive, up-to-date treatise covering embryology, anatomy, etiology, clinical manifestations, diagnoses, and treatment modalities of surgical endocrine diseases. The authors explore the pertinent surgical endocrinology topics with a South Asian perspective. Color illustrations, flowcharts and tables make the topics lucid for professionals. This book provides the essential information surgeons require for evaluation and management of patients, both with straight forward, and complex endocrine problems. Key Features Focusses on concise yet comprehensive, up-to-date coverage of surgical endocrine diseases Discusses Robot Assisted Endocrine Surgery and explores its impact on healthcare finances Highlights the difference between practices used in western and resource limited countries by incorporating a South Asian perspective for region specific diseases.

This book covers the scope of cranial nerve monitoring of all cranial nerves that are of practical importance in head, neck, and thyroid surgery. It discussed enhanced patient outcomes in a wide array of surgical procedures in the head and neck that require the maintenance of complex regional functions by protecting cranial nerve integrity. Organized into four parts, the book begins with Part I offering historical perspectives on the subject while simultaneously reviewing various basic and advanced electrophysiology. Part II thoroughly reviews the extra-temporal bone facial nerve (CN VII), Glossopharyngeal Nerve (CN IX), Vagal/Recurrent Laryngeal Nerve (CN X), Spinal Accessory Nerve (CN XI), and Hypoglossal Nerve (CN XII). Subsequent chapters in Part III provide a complete and applied understanding of the neurophysiological principles that facilitate the surgeon's ability to monitor any nerve and intraoperative neural stimulation and nerve monitoring. The book presents various techniques as the standard of care to provide optimal neural detection, understand the neural functional real-time status during surgery and optimize specific surgical outcomes such as thyroid surgical outcomes. Closing chapters offer essential conversations regarding ethical considerations in nerve monitoring and medical malpractice. Filling a gap in the literature, Intraoperative Cranial Nerve Monitoring in Otolaryngology: Head and Neck Surgery provides a single source for surgeons who wish to optimize their outcomes in patient care and accelerate their learning curve to the level of more experienced surgeons.

This book is one of the first to evaluate the role of Steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements and focuses on the importance of steroidal hormones in the pathogenesis and therapeutic management of the autoimmune rheumatic diseases. In particular, the chapters analyze the mechanisms of action and the involvement of adrenal steroids (glucocorticoids) in the neuroendocrine immune system, including effects on the elderly.
The perturbations of the HPA axis as a source of altered steroidal synthesis will be discussed and related to some interesting pathological conditions that commonly complicate the autoimmune rheumatic diseases such as psychosis or fibromyalgia. Concerning the role of gonadal steroids (sex hormones), several chapters will discuss clinical and epidemiological evidences of their role, as well as their effects as risk factors in autoimmune rheumatic diseases, including a section on pediatrics.
*The premier issue evaluating the role of steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements
*Documents the latest research and indicate recent and coming new therapeutic-biological approaches to the therapy
*The book will present therapeutic perspectives concerning the new glucocorticoids, and the effects of biological drugs on their synthesis

In the past decade, there has been increasing recognition of thyroid diseases as a common health problem. While there have been few major new advances in treatment, there is much greater understanding of why thyroid disorders occur and the long-term health effects of thyroid disease. As people with thyroid disease begin to know more about their disorder, they are able to co-operate better with treatment and their anxieties about the problem can be significantly reduced.
This fourth edition of Thyroid Disease: The Facts provides a reader-friendly source of information and reassurance for those people with thyroid disorders and their families. The book covers the wide range of conditions associated with thyroid dysfunction, from simple goitre to more complex disorders such as Graves' disease and Hashimoto's thyroiditis. This edition also includes several completely new chapters, including one specifically devoted to thyroid disorders in infants, children and adolescents. Each chapter concludes with a useful Question and Answer section.

Improving glycemic, lipid, and blood pressure outcomes is the essence of diabetes care. Maintaining consistently positive results is an ongoing challenge for every healthcare professional. After years of clinical practice, Mayer Davidson, MD, has developed a series of algorithmic techniques that can increase positive results. Based on the American Diabetes Association's Standards of care, this book offers detailed treatment algorithms that have been shown to be clinically effective in improving outcomes in people with diabetes.In this second edition, Davidson has revised and updated the algorithms to match the ever-changing ADA Standards of Care. Sections include: Laying the Groundwork: Background for Evidence-Based ADA Guidelines forStandards of Diabetes Care, Evidence-Based Principles of Dietary Therapy, Glycemia, Dyslipidemia, and Hypertension.

Vassopressin, Volume 111, the latest release in the Vitamins and Hormones series, first published in 1943, covers the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms, with this release focusing on topics relating to hepcidin, bacterial infection, and iron overload, the role of heparan sulfates in hepcidin regulation, hepcidin CDNA and human gene sex hormones, growth factors and hepcidin, HFE gene polymorphisms and hereditary hemochromatosis, hepcidin and il-1beta, hepcidin-ferroportin axis, cardiomyocyte hepcidin, adipocyte iron, leptin and hepcidin, regulators of hepcidin expression, and much more.

Written primarily for 16-19 year old students, this primer aims to extend students' knowledge and inspire them to take their school-level learning further. It explores topics that are familiar from the curriculum and also introduces new ideas, giving students a first taste of the study of biology beyond school-level and demonstrating how concepts frequently encountered at school are relevant to and applied in current research. This is the ideal text to support students who are considering making the transition from studying biology at school to university. This primer introduces students to key elements of the endocrine system, including the structure and function of the major types of hormones. It explores the role of hormones in disease, in development, in reproduction and in behaviour. Although humans are its main focus, it draws on illuminating examples from a range of other species, including sex changes and aggression in fish, metamorphosis in amphibians, induction of ovulation in different species, and bonding behaviour in birds. The final section of the book looks at ways in which hormones can be used in medicine and agriculture, and can be abused to enhance sporting performance and weight loss. This primer will expand the breadth and depth of student understanding of the endocrine system, its variety, and its huge importance.

Frank Nawroth thematisiert das Social Freezing und die zugehoerige Beratung, die nicht nur Chancen, sondern auch denkbare Komplikationen und Grenzen der Methode aufzeigen muss. Zum Beispiel haben die gesellschaftspolitisch nicht optimal geloeste Problematik des moeglichen Karriere-Nachteils einer berufstatigen Mutter oder die haufig bestehende Schwierigkeit, den geeigneten Partner zu finden, bei gleichzeitig verbesserten Kryokonservierungsmethoden dazu gefuhrt, dass Frauen ohne medizinische Indikation uber das Einfrieren ihrer Eizellen nachdenken. Die Technologie selbst ist seit Langerem Routine vor fertilitatsbeeintrachtigenden Therapien onkologischer Erkrankungen (Operation, Strahlen- und/oder Chemotherapie) im reproduktiven Alter.

The articles comprising this volume were first presented at the World Congress on Neurohypophysial Hormones held in Bordeaux, France on September 8-12, 2001. This conference brought together more than 170 scientists from 18 countries who belong to the different fields of interest representing research in the hypothalamo-neurohypophysial system.

Two neurohypophysial neurohormones, oxytocin and vasopressin, exert a variety of central and peripheral actions and thus involve different scientific domains, which too often, even today, do not always find the appropriate occasion to interact. This volume is composed of chapters dealing with topics varying from basic and clinical neurosciences and neuroendocrinology, to reproductive, renal, cardiovascular physiology and pathology. It encompasses all areas of current neurohypophysial research and should be of vital interest as an integrative reference volume to specialized investigators and as an excellent introductory text to students, scientists and clinicians not yet closely familiar with the field. To ensure novelty and to make sure that all topics of current importance were covered, plenary and symposium speakers as well as poster presentations concentrated on recent advances made in the last few years.